Field Data
UniProt Accession: Q86YR7
Gene Name: MCF2L2
Gene Synonim: DRG, KIAA0861
GAP/GEF: GEF
Description: Probable guanine nucleotide exchange factor MCF2L2 (Dbs-related Rho family guanine nucleotide exchange factor) (MCF2-transforming sequence-like protein 2)
Keywords: Alternative splicing;Complete proteome;Diabetes mellitus;Guanine-nucleotide releasing factor;Polymorphism;Reference proteome
Entrez ID: 23101
Ensembl Gene ID: ENSG00000053524
Ensembl Protein ID: ENSP00000420070
Our Specificity
Literature Specificity None
Domain Composition:

Cellular Component

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

KEGG

Field Data
Localization in this study: plasma_membrane, vesicles
Localization in the literature:

Confocal Images

Card image cap
Card image cap
Card image cap

Cytochalasin D Screen Negative

Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>MCF2L2
atgctgtcttgcttaaaagaagagatgcctccccaggagctcacccggcgactggccaca
gtgatcactcatgtcgatgaaattatgcagcaggaagtcagacccctgatggcggtggag
ataatagaacaacttcacagacaatttgccattctttcaggaggccgaggggaggatggc
gcccccatcatcacgttcccagagttttcggggttcaaacacatcccagatgaagacttc
ctgaatgtcatgacctacctgactagcatccccagtgtggaggctgccagcattggattc
attgttgttatcgacagacgaagagacaagtggagctccgtaaaggcatccttgacacga
atagctgtggcatttccaggaaacttacagctcatattcatccttcgtccatctcgcttt
atccagaggacattcactgacattggcattaaatactatcgaaatgagtttaaaacgaaa
gtgccgatcatcatggtaaactctgtctctgaccttcacggctacatcgacaaaagccaa
ctgacccgggaattaggggggactttggaatatcgccacggtcagtgggtaaatcaccgc
actgccatcgaaaactttgccttgaccttgaagaccactgcccagatgctgcagacgttt
gggtcctgcctggccacagcagagctgcccagaagcatgctatccacggaagaccttctc
atgtcccacacaaggcagcgggacaagctgcaggatgagctgaaattacttggaaagcag
gggaccacattgctgtcatgcatccaagaaccagcaaccaaatgtcccaacagcaaactc
aatctcaaccaacttgagaatgtaactaccatggaaaggttattagttcaactggatgaa
acagaaaaagcctttagtcacttttggtctgagcatcatctgaagcttaaccagtgccta
caactacagcattttgagcacgatttttgtaaggctaagcttgccctggataatttgctg
gaagagcaagcagagtttacaggcattggagacagcgtgatgcacgtggagcagattctt
aaggaacacaaaaaactggaggaaaaaagccaggagcccctggaaaaggcccagctgctg
gcactggttggggaccagctcatccaaagccaccattatgcagcagatgccatcaggccc
cggtgtgtggagctcaggcacctctgtgacgatttcatcaatggaaacaagaaaaaatgg
gacattttaggaaagtccttagagtttcatagacagctggacaaggtcagccaatggtgt
gaggcaggaatctacctcttggcttcccaagctgtagacaagtgccagtctcgagaaggg
gttgatatcgccttgaacgacattgcgacattcctgggcacagtcaaggagtacccgttg
ctcagccccaaggagttttacaacgagtttgagttgctgctcaccctcgatgcaaaggcc
aaagcccagaaagttttgcagaggctggatgatgtccaggaaatatttcacaagaggcaa
gtgagtctgatgaaactggcagccaaacagactcgtccagtgcaacctgtggccccacat
cctgagtcttcaccaaaatgggtgtcatcaaaaaccagccagccctccacctcggtccct
ctagctcgtcctctgagaacgtctgaggaaccttatacggagacagagttgaactcccgg
ggaaaggaagatgatgagactaaatttgaagtcaagagtgaagaaatctttgaaagccat
catgaaagggggaaccctgagctggagcagcaggccaggctcggagacctttccccccgc
aggcgcattatacgtgacttgcttgagactgaagagatttacataaaagagattaaaagc
ataattgatggatatatcactccaatggattttatttggctaaagcatctaattccagat
gttcttcagaataacaaggactttctctttgggaatattagagaactttacgaatttcac
aacaggacttttctaaaagagttggaaaagtgtgctgagaaccctgaacttctggcacat
tgctttctcaagagaaaagaagatcttcagatatattttaaataccataagaatctgccc
cgagctagggcaatctggcaagagtgtcaagactgcgcctactttggggtatgccagcgc
caactggatcacaatctccctctttttaagtatctcaaaggaccaagccagagacttata
aaataccagatgctgttgaagggtctgctggatttcgagtctcctgaagatatggagata
gacccaggtgaactaggaggctcggctaaggatgggccaaagagaaccaaagattcagca
ttctcaactgaactacaacaagctttggcagtgatagaggatttgatcaagtcctgtgag
ttggctgtggacctagcagcagtgactgaatgtccggacgatattggaaaactaggcaag
ctgttgctgcacggccctttcagcgtctggacaattcacaaggatcgttataaaatgaag
gatttgattcgatttaaacccagccagaggcaaatctacctatttgaaaggggaatagtg
ttctgtaagatacgaatggagcctggggaccagggattatctcctcattacagcttcaag
aagaccatgaagctgatgacactttcaattcgccagcttggaagggggagccatagaaag
tttgagattgccagtcgaaatggacttgagaaatacatcctgcaggcagcttcaaaagaa
atcagagactgttggttttcagaaataagtaaattattgatggaacaacaaaataatatc
aaagaccaaggaaatccacagtttgaaatgagcacgagcaaaggcagtggagcaggatcc
ggaccatggattaaaaatatggaaagagctaccactagcaaggaagacccggcctccagc
acaggagggattaaaggctgctccagcagggagtttagctccatggacacctttgaagac
tgtgaaggcgcagaagacatggaaaaggagagcagtgctctgagtctcgcgggccttttc
cagtcggacgacagtcacgaaacctgttcctccaaatctgctttcctggagaggggagaa
agcagccagggagaaaaagaagaacgcgatgaggaggaaacggcgacccgcagcaccgag
gaggagcgcgctggggcgtccacgggccggctggctcctgcgggggcgacggctggtttc
caggcgagggcgctgcgcccgaggacctccgcccaggagagcttaatta

Protein Sequence

>MCF2L2
MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQLHRQFAILSGGRGEDG
APIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIVVIDRRRDKWSSVKASLTR
IAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPIIMVNSVSDLHGYIDKSQ
LTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQTFGSCLATAELPRSMLSTEDLL
MSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCPNSKLNLNQLENVTTMERLLVQLDE
TEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKLALDNLLEEQAEFTGIGDSVMHVEQIL
KEHKKLEEKSQEPLEKAQLLALVGDQLIQSHHYAADAIRPRCVELRHLCDDFINGNKKKW
DILGKSLEFHRQLDKVSQWCEAGIYLLASQAVDKCQSREGVDIALNDIATFLGTVKEYPL
LSPKEFYNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPH
PESSPKWVSSKTSQPSTSVPLARPLRTSEEPYTETELNSRGKEDDETKFEVKSEEIFESH
HERGNPELEQQARLGDLSPRRRIIRDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPD
VLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLP
RARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEI
DPGELGGSAKDGPKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGK
LLLHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFK
KTMKLMTLSIRQLGRGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNI
KDQGNPQFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFED
CEGAEDMEKESSALSLAGLFQSDDSHETCSSKSAFLERGESSQGEKEERDEEETATRSTE
EERAGASTGRLAPAGATAGFQARALRPRTSAQESLI

  • Gold
  • Silver
  • Bronze
  • IntAct