Field Data
UniProt Accession: Q8IW93
Gene Name: ARHGEF19
Gene Synonim:
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 19 (Ephexin-2)
Keywords: Alternative splicing;Complete proteome;GTPase activation;Guanine-nucleotide releasing factor;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 128272
Ensembl Gene ID: ENSG00000142632
Ensembl Protein ID: ENSP00000270747
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005829cytosol

Molecular Function


GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process


GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0032956regulation of actin cytoskeleton organization
GO:0042060wound healing
GO:0043065positive regulation of apoptotic process
GO:0035023regulation of Rho protein signal transduction
GO:0060071Wnt signaling pathway, planar cell polarity pathway

Reactome


Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG



Field Data
Localization in this study: focal_adhesions, plasma_membrane
Localization in the literature: plasma membrane

Confocal Images


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Cytochalasin D Screen Negative


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TIRF


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF19
atggactgtgggccacctgctaccctccagccccacctgactgggccacctggcactgcc
caccaccctgtagcagtgtgccagcaggagagtctgtcctttgcagagctgcccgccctg
aagcccccgagcccagtgtgtctggaccttttccctgttgccccagaggagcttcgggct
cctggcagccgctggtccctggggacccctgcccctctccaagggttgctatggccatta
tccccaggaggctcagatacagagatcaccagcggggggatgcggcccagcagggctggc
agctggccacactgtcctggtgcccagcccccagctctggagggaccctggagtccccga
cacacacagccacagcgccgggccagccacggctcggagaagaagtctgcctggcgcaag
atgcgggtgtaccagcgtgaagaggtccccggctgccccgaggcccacgctgtcttccta
gagcctggccaggtagtgcaagagcaggccctgagcacagaggagcccagggtggagttg
tctgggtccacccgagtgagcctcgaaggtcctgagcggaggcgcttctcggcatcggag
ctgatgacccggctgcactcttctctgcgcctggggcggaattcagcagcccgggcactc
atctctgggtcaggcaccggagcagcccgggaagggaaagcatctggaatggaggctcga
agtgtagagatgagcggggaccgggtgtcgcggccagcccctggtgactcacgagagggc
gattggtccgagcccaggctagacacacaggaagagccgcctttggggtccaggagcacc
aacgagcggcgccagtctcgattcctccttaactccgtcctctatcaggaatacagcgac
gtggccagcgcccgcgaactgcggcggcagcagcgcgaggaggagggcccgggggacgag
gccgagggcgcagaggaggggccggggccgccgcgggccaacctctcccccagcagctcc
ttccgggcgcagcgctcggcgcgaggctccaccttctcgctgtggcaggatatccccgac
gtacgcggcagcggcgtcctggccacgctgagcctgcgggactgcaagctgcaggaggcc
aagtttgagctgatcacctccgaggcctcctacatccacagcctgtcggtggctgtgggc
cacttcttaggctctgccgagctgagcgagtgtctgggggcgcaggacaagcagtggctg
ttttccaaactgcccgaggtcaagagcaccagcgagaggttcctgcaggacctggagcag
cggctggaggcagatgtgctgcgcttcagcgtgtgcgacgtggtgctggaccactgcccg
gccttccgcagagtctacctgccctatgtcaccaaccaggcctaccaggagcgcacctac
cagcgcctgctcctggagaaccccaggttccctggcatcctggctcgcctggaggagtct
cctgtgtgccagcgtctgccccttacctccttccttatcctgcccttccagaggatcacc
cgcctcaagatgttggtggagaacatcctgaagcggacagcacagggctctgaagacgaa
gacatggccaccaaggccttcaatgcgctcaaggagctggtgcaggagtgcaatgctagt
gtacagtccatgaagaggacagaggaactcatccacctgagcaagaagatccactttgag
ggcaagattttcccgctgatctctcaggcccgctggctggttcggcatggagagttggta
gagctggcaccactgcctgcagcaccccctgccaagctgaagctgtccagcaaggcagtc
tacctccacctcttcaatgactgcttgctgctctctcggcggaaggagctagggaagttt
gccgttttcgtccatgccaagatggctgagctgcaggtgcgggacctgagcctgaagctg
cagggcatccccggccacgtgttcctcctccagctcctccacgggcagcacatgaagcac
cagttcctgctgcgggcccggacggaaagtgagaagcagcgatggatctcagccttgtgc
ccctccagcccccaggaggacaaggaggtcatcagtgagggggaagattgcccccaggtt
cagtgtgttaggacatacaaggcactgcacccagatgagctgaccttggagaagactgac
atcctgtcagtgaggacctggaccagtgacggctggctggaaggggtccgcctggcagat
ggtgagaaggggtgggtgccccaggcctatgtggaagagatcagcagcctcagcgcccgc
ctccgaaacctccgggagaataagcgagtcacaagtgccaccagcaaactgggggaggct
cctgtgttaatta

Protein Sequence

>ARHGEF19
MDCGPPATLQPHLTGPPGTAHHPVAVCQQESLSFAELPALKPPSPVCLDLFPVAPEELRA
PGSRWSLGTPAPLQGLLWPLSPGGSDTEITSGGMRPSRAGSWPHCPGAQPPALEGPWSPR
HTQPQRRASHGSEKKSAWRKMRVYQREEVPGCPEAHAVFLEPGQVVQEQALSTEEPRVEL
SGSTRVSLEGPERRRFSASELMTRLHSSLRLGRNSAARALISGSGTGAAREGKASGMEAR
SVEMSGDRVSRPAPGDSREGDWSEPRLDTQEEPPLGSRSTNERRQSRFLLNSVLYQEYSD
VASARELRRQQREEEGPGDEAEGAEEGPGPPRANLSPSSSFRAQRSARGSTFSLWQDIPD
VRGSGVLATLSLRDCKLQEAKFELITSEASYIHSLSVAVGHFLGSAELSECLGAQDKQWL
FSKLPEVKSTSERFLQDLEQRLEADVLRFSVCDVVLDHCPAFRRVYLPYVTNQAYQERTY
QRLLLENPRFPGILARLEESPVCQRLPLTSFLILPFQRITRLKMLVENILKRTAQGSEDE
DMATKAFNALKELVQECNASVQSMKRTEELIHLSKKIHFEGKIFPLISQARWLVRHGELV
ELAPLPAAPPAKLKLSSKAVYLHLFNDCLLLSRRKELGKFAVFVHAKMAELQVRDLSLKL
QGIPGHVFLLQLLHGQHMKHQFLLRARTESEKQRWISALCPSSPQEDKEVISEGEDCPQV
QCVRTYKALHPDELTLEKTDILSVRTWTSDGWLEGVRLADGEKGWVPQAYVEEISSLSAR
LRNLRENKRVTSATSKLGEAPVLI

  • Gold
  • Silver
  • Bronze
  • IntAct