Field Data
UniProt Accession: Q8IWW6
Gene Name: ARHGAP12
Gene Synonim:
GAP/GEF: GAP
Description: Rho GTPase-activating protein 12 (Rho-type GTPase-activating protein 12)
Keywords: Alternative splicing;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome;Repeat;SH3 domain
Entrez ID: 94134
Ensembl Gene ID: ENSG00000165322
Ensembl Protein ID: ENSP00000379448
Our Specificity Rac1
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol
GO:0001891phagocytic cup

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0007015actin filament organization
GO:0002011morphogenesis of an epithelial sheet
GO:0006911phagocytosis, engulfment
GO:0007165signal transduction
GO:0051058negative regulation of small GTPase mediated signal transduction

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: focal_adhesions, plasma_membrane
Localization in the literature: plasma membrane

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP12
atgaaaatggctgacagaagtgggaagattattccaggacaagtgtatattgaggtggaa
tatgattatgaatatgaagcaaaggacagaaagattgtgataaaacaaggggagaggtac
atcttggtgaaaaagaccaatgatgactggtggcaagtcaagccagatgaaaactccaaa
gcgttttatgtgccagcccagtatgtgaaggaggtcacgcgcaaagctctcatgccacct
gttaagcaggtagctggtctgccaaataactccacgaaaataatgcagagtttgcatctt
cagagatcaacagaaaatgtgaacaaattgcctgagctttcaagtttcggaaagccatcg
tcatctgttcaaggaacaggtcttattcgtgatgccaatcagaattttggacccagttat
aatcaaggtcagactgtcaacctaagcctggacctgacccataataacggaaagtttaac
aatgactcacattctcctaaagtttccagccagaataggacacgctcatttggtcatttt
cccggtccagagttcttggatgtagagaaaactagcttctcccaggaacaatcttgtgat
tccgcaggagaaggctctgaaagaatacatcaagattctgaatctggtgatgaacttagc
agcagctccactgaacagataagggcaaccacacctccaaatcaaggaaggccagattct
cctgtctatgctaaccttcaagaactgaaaatatcccagtctgctcttcccccacttcct
gggagcccggcaattcagattaatggagaatgggaaactcataaagacagctcagggcgt
tgctattactataacagagggacacaggaaagaacttggaaacctcctcgttggactcgg
gatgcaagcatcagcaaaggagatttccaaaatccaggggatcaagagcttctttcatcg
gaagaaaactactacagcacttcttacagccagtcagatagtcagtgtggttctcctcca
aggggttggtcagaagagttggatgaacgtgggcataccttatataccagtgactatact
aatgaaaagtggctcaagcatgttgatgatcaaggtagacaatattactacagtgcagac
ggatctcggtcagaatgggaattgccaaagtataatgcttcatcccagcagcaaagagaa
ataattaaaagtaggagcctggacaggcggctgcaagaaccaatagtattaacaaagtgg
agacatagcaccattgtattggacactaatgataaggaatctccaactgcctcaaaaccc
tgctttcctgaaaatgagtcttctccctcctcaccaaagcaccaagatacagatcaagag
aaatatggattattaaatgtaacaaaaattgctgaaaatgggaaaaaggttcgaaagaac
tggttgtcttcttgggcggtgttgcagggttcatctttactttttaccaaaactcaagga
agtagcacaagttggtttggcagtaatcagtccaaaccagagttcacagtggacctcaag
ggggcaacaattgagatggcttcaaaggataaatccagcaaaaagaatgtatttgagctg
aaaactcgtcaaggaacagaactgctaattcagtctgacaatgacactgttattaatgat
tggtttaaagttcttagtagtacaatcaataatcaggcagtagaaactgatgaaggaatt
gaagaggagataccggattcaccaggaatagaaaagcatgataaagaaaaggaacaaaag
gatcccaaaaagcttcgttcctttaaagtatctagcatagattcttcagaacagaaaaaa
accaagaaaaacttaaagaagtttcttacacgacgccccactttgcaagctgttcgtgaa
aaaggttatattaaagatcaggtatttggatccaatctcgctaatctgtgtcagagagag
aatggcacagtaccaaagtttgtgaagttatgtattgaacatgttgaagaacatggtttg
gatattgatgggatatacagagtaagtggcaacctcgcagtgatccagaaactaaggttt
gcagtcaatcatgatgagaaattggacttgaatgacagtaaatgggaagatattcatgtc
attactggagccctcaaaatgttttttcgagaattaccagaacctctttttacatttaat
cattttaatgattttgttaatgcaattaagcaagaaccaagacagcgagtcgctgctgtt
aaggacctaatcagacagttgccaaagccaaaccaagacacaatgcagattcttttccga
catctcagaagagttatagaaaatggagagaaaaatcgaatgacctatcagagtatagca
attgtttttggtcccactctattaaaaccagaaaaagagactggtaatatagcagttcat
actgtgtaccagaatcagattgtagaattaattcttctggaactgagttccatcttcgga
cgtttaatta

Protein Sequence

>ARHGAP12
MKMADRSGKIIPGQVYIEVEYDYEYEAKDRKIVIKQGERYILVKKTNDDWWQVKPDENSK
AFYVPAQYVKEVTRKALMPPVKQVAGLPNNSTKIMQSLHLQRSTENVNKLPELSSFGKPS
SSVQGTGLIRDANQNFGPSYNQGQTVNLSLDLTHNNGKFNNDSHSPKVSSQNRTRSFGHF
PGPEFLDVEKTSFSQEQSCDSAGEGSERIHQDSESGDELSSSSTEQIRATTPPNQGRPDS
PVYANLQELKISQSALPPLPGSPAIQINGEWETHKDSSGRCYYYNRGTQERTWKPPRWTR
DASISKGDFQNPGDQELLSSEENYYSTSYSQSDSQCGSPPRGWSEELDERGHTLYTSDYT
NEKWLKHVDDQGRQYYYSADGSRSEWELPKYNASSQQQREIIKSRSLDRRLQEPIVLTKW
RHSTIVLDTNDKESPTASKPCFPENESSPSSPKHQDTDQEKYGLLNVTKIAENGKKVRKN
WLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDLKGATIEMASKDKSSKKNVFEL
KTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETDEGIEEEIPDSPGIEKHDKEKEQK
DPKKLRSFKVSSIDSSEQKKTKKNLKKFLTRRPTLQAVREKGYIKDQVFGSNLANLCQRE
NGTVPKFVKLCIEHVEEHGLDIDGIYRVSGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHV
ITGALKMFFRELPEPLFTFNHFNDFVNAIKQEPRQRVAAVKDLIRQLPKPNQDTMQILFR
HLRRVIENGEKNRMTYQSIAIVFGPTLLKPEKETGNIAVHTVYQNQIVELILLELSSIFG
RLI

  • Gold
  • Silver
  • Bronze
  • IntAct