Field Data
UniProt Accession: Q8IZD9
Gene Name: DOCK3
Gene Synonim: KIAA0299, MOCA
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 3 (Modifier of cell adhesion) (Presenilin-binding protein) (PBP)
Keywords: Chromosomal rearrangement;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Phosphoprotein;Reference proteome;SH3 domain;SH3-binding
Entrez ID: 1795
Ensembl Gene ID: ENSG00000088538
Ensembl Protein ID: ENSP00000266037
Our Specificity Rac1
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005085guanyl-nucleotide exchange factor activity
GO:0017124SH3 domain binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0007264small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-983231Factors involved in megakaryocyte development and platelet production

KEGG

Field Data
Localization in this study: focal_adhesions, plasma_membrane
Localization in the literature: cytosolic plasma membrane

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK3
atgtggacccccacggaggaggagaaatacggcgtagtgatatgcagctttcgaggatct
gtccctcaagggttggtcttagaaataggagaaacagtccagattcttgaaaaatgtgaa
ggttggtacagaggagtttcaacaaagaagccaaatgtgaaggggatctttcctgcaaat
tacattcacttgaaaaaggcaattgtcagtaatagggggcagtatgaaactgtggttcca
cttgaagattctattgtgactgaggttacagcaactctacaagaatgggcaagtttgtgg
aaacagttgtatgtgaaacacaaagtagatcttttctacaaactacgccatgtgatgaat
gaacttattgacctgcgaaggcagctactgtctggtcacctgactcaggatcaggtgcgg
gaggttaagcggcacatcaccgtgcgcctggactggggtaatgaacatttgggcctggac
ctggtgcctcggaaggactttgaagtagtggactcggaccagattagtgtctcagatctc
tataagatgcatttatctagccggcagagtgtacagcaaagcacatcccaggtagataca
atgcgcccacgtcatggggaaacatgtcggatgccagtgccacatcacttcttcctcagc
ctgaagagtttcacttacaatactattggggaagataccgatgtcttcttttccttatat
gacatgagggaaggcaagcagatcagtgagcggtttctggtaagactgaacaagaatggt
gggccgaggaacccagagaagatagaacgaatgtgtgccctttttacagatctgagcagc
aaagatatgaagagagatttgtatatcgttgcccatgtgatccgaataggccggatgctc
ctgaacgactcaaagaaaggtcctcctcacctgcactacaggcgaccatatggctgtgcg
gtcctaagcatcttggatgtcctacagtcactcacagaagtaaaggaagaaaaggatttt
gttcttaaggtttacacgtgcaacaacgagagtgagtggtcccagatccacgagaacatc
atccgaaagtccagtgccaagtactctgcccccagcgccagccatggtcttatcatttct
ctgcagcttcttcgtggagacatggaacagattcggagagaaaatcccatgatatttaat
aggggattggcaattacaagaaaattgggatttcctgatgtcattatgccaggtgatatc
cgcaatgacctgtacctaaccctggagaagggggatttcgagagaggaggaaagagtgta
caaaagaatattgaagtgaccatgtatgtgctttatgcagatggagaaatcttgaaggat
tgcatcagcttgggttcaggagagccaaataggagttcctaccactcctttgtcctctac
cacagtaatagtcctcgctggggagaaattatcaaattgcctatccccattgaccggttc
cggggctcccacctgcgctttgagttcagacattgttccacaaaggacaaaggggaaaag
aaactctttggctttgcattctcaaccctgatgcgtgatgatggcaccaccctctcagat
gatattcacgagctttatgtgtacaagtgtgatgagaatagcacgtttaataaccatgct
ctgtacctgggcctgccctgctgcaaagaggactacaatggctgccctaatattccttct
agcctcatcttccagcgcagcaccaaagagtctttcttcatctccactcagctctcctct
accaaactcacccagaatgtggacctcctagctctgctgaagtggaaagccttccccgac
cggatcatggatgtactagggcggctgcggcatgtcagtggggaggaaattgttaagttt
ctgcaggacatcttagatacactctttgtgattttggatgataatacagagaagtacggc
ctgttggtttttcagtctctggtgttcatcatcaacctgctccgagacatcaagtatttt
cactttcgacctgtgatggacacgtatatccagaagcactttgctggagctctggcatac
aaggagctcatccgctgtttgaagtggtatatggactgctcagcagaactgattcgacag
gaccacattcaagaagctatgcgggccttggagtaccttttcaagttcattgtacagtca
cggatcctgtactcacgagccacttgtggaatggaagaggaacaattcagatccagtatc
caagaacttttccagtccatccggtttgtgctcagtctggacagccgaaactcagaaaca
ctcctttttactcaggctgcactcctcaattctttcccaaccatctttgatgagcttctg
caaatgttcaccgtgcaagaggtggcagagtttgtgagagggacactggggagcatgccc
agcactgtgcacattgggcagtcaatggacgtggtcaagctgcagtccattgccaggaca
gtggatagccgcctgttttctttctcagaatcccgccgcatcctgcttcctgtggttctc
catcacattcaccttcacctgaggcagcagaaagagctgctaatttgctcagggattctt
ggcagcatcttctccatcgtcaagaccagctctctggaggcagatgtcatggaggaagta
gagatgatggtggagagcctcctggacgtgctcttgcagactctgctcaccatcatgagc
aaatcgcacgctcaggaggcggtaagagggcagcggtgcccgcagtgcacagccgagatc
actggcgagtatgtgtcctgccttctctcactgctccgccagatgtgtgacacccatttc
cagcacctcctggacaacttccagagcaaagatgaactcaaggaatttctgctgaagatt
ttttgcgtgttccggaacctgatgaagatgagtgtcttccctcgggactggatggtaatg
agactgctcacaagcaatattatagtcactactgtccagtacctgtcctctgcactgcac
aagaatttcacagagactgactttgactttaaggtgtggaattcttactttagcctggca
gttctattcataaatcagccaagccttcagctagaaattatcacctcagccaaaaggaag
aagattctagataagtatggggacatgcgtgtaatgatggcctatgaactgttcagcatg
tggcagaatttgggtgaacataagatccactttattccgggaatgattggtccttttctg
ggtgtgacactggtcccacagccagaagtacggaatatcatgattcccatctttcatgac
atgatggactgggagcagagaaaaaatggcaacttcaaacaggtggaggccgagttgatt
gacaagctggacagcatggtgtcagaagggaaaggtgacgagagctacagggagctcttc
agcctactaacccagctgtttgggccctaccccagcctgctggagaaggttgaacaagaa
acatggcgcgagaccggcatttcctttgtgacctcagtcacccgcctcatggaacgtctt
cttgactacagggactgcatgaaaggagaggaaacagagaataagaagataggctgcact
gttaacctgatgaatttttacaaatctgagattaacaaggaagaaatgtatatccgctac
atccataagctttgtgacatgcacttgcaggccgaaaactacacagaggccgcatttacc
ctgctcctttactgtgagctgctgcagtgggaggaccggccactacgggaattcctccac
tacccatcgcagacagagtggcagcggaaggagggactgtgccggaagatcattcactac
ttcaacaaaggcaagagctgggagtttgggatcccactgtgcagggagctggcgtgtcag
tacgagagcctctatgattaccagagcctcagctggattcggaaaatggaggccagctac
tatgacaacattatggagcagcaacgcctggagcctgagttctttcgggtcggcttctat
ggcaggaagtttcctttctttcttcggaacaaagaatacgtgtgccgtggccatgactac
gagaggctggaggccttccagcagaggatgctcagtgagtttccgcaggctgtcgccatg
cagcaccccaaccatcctgatgacgccatcctacagtgcgatgcccagtacttgcagatc
tatgcagtgacgcccattccagattatgtggatgttctgcagatggatagggtaccagat
cgagtcaagagcttctatcgcgtcaacaatgtgaggaagttccggtatgacaggcctttt
cacaaaggccccaaggacaaggagaatgaattcaagagcctgtggattgaacgtaccaca
ctgaccctgacccacagcttgcctggcatctctcggtggtttgaagtggagaggagggaa
ctggtggaggtgagccctctggagaatgccatccaagtggttgagaataagaaccaggag
ctacgctccctgatcagccagtatcaacacaagcaggtgcatggcaacattaacctgcta
agcatgtgcctgaatggtgtcattgatgcagctgtcaatggaggcattgcacgctatcag
gaggccttctttgataaagattacatcaacaagcacccaggagatgctgagaagatcacc
cagctcaaggagcttatgcaggagcaggttcatgtccttggagttgggctagcagttcat
gagaagtttgtgcacccagaaatgcggcctctgcataagaagctaattgatcagttccag
atgatgcgggccagtctctaccatgagtttccaggtttggataagctaagtcctgcatgt
tcaggcaccagcaccccacggggaaatgttctggcatcccatagccccatgagtccggag
agcatcaagatgacccaccggcacagccccatgaacttgatgggcacaggccgccattca
tcatcctctctctcctcacatgcgtctagtgaagcaggaaacatggtgatgctgggtgac
ggctccatgggtgatgctcctgaggacctgtaccaccacatgcagctcgcgtatcccaac
cccaggtaccaaggctcagtcaccaacgtctctgttctgtcctcgtcccaggcaagccct
tcttcctccagcctgagttccactcactcagcaccatcccagatgattacctctgcccct
tccagtgcccgaggctctccctctctgccagataagtaccgccatgcccgtgaaatgatg
ttgttgctgcccacataccgggaccgcccaagcagtgccatgtatccagcagccatcctg
gagaacggacagccgccgaatttccagcgagccctgttccagcaagtggtcggagcctgc
aaaccctgcagtgatcccaatctgtctgtggctgaaaaaggtcattactccctacacttt
gacgccttccaccaccctctgggtgatacccccccagccctccctgcccggaccctgcgc
aagtctcctctccaccctatcccagcctcccccacaagcccccagtcaggtctggacggc
agcaactctacgctgtccggcagtgccagcagcggcgtgtcctccttgagtgagagtaac
tttgggcactcctcggaggccccacctcgcactgacaccatggactccatgccaagtcag
gcctggaatgctgacgaagatcttgagccaccctacctccctgtccactacagcctctct
gagtctgccgtcctggactccatcaaggcccagccatgccgaagccactcagccccaggg
tgcgtcatccctcaggaccccatggacccgcctgcgctgccgcccaagccctaccacccc
cgcctgccggccctggagcacgatgagggggtgctgctgcgtgaagagactgagaggcct
cgaggcctgcaccgcaaggctccattgcctcctgggagcgctaaggaggagcaggcccgc
atggcctgggagcacggccgaggggagcagttaatta

Protein Sequence

>DOCK3
MWTPTEEEKYGVVICSFRGSVPQGLVLEIGETVQILEKCEGWYRGVSTKKPNVKGIFPAN
YIHLKKAIVSNRGQYETVVPLEDSIVTEVTATLQEWASLWKQLYVKHKVDLFYKLRHVMN
ELIDLRRQLLSGHLTQDQVREVKRHITVRLDWGNEHLGLDLVPRKDFEVVDSDQISVSDL
YKMHLSSRQSVQQSTSQVDTMRPRHGETCRMPVPHHFFLSLKSFTYNTIGEDTDVFFSLY
DMREGKQISERFLVRLNKNGGPRNPEKIERMCALFTDLSSKDMKRDLYIVAHVIRIGRML
LNDSKKGPPHLHYRRPYGCAVLSILDVLQSLTEVKEEKDFVLKVYTCNNESEWSQIHENI
IRKSSAKYSAPSASHGLIISLQLLRGDMEQIRRENPMIFNRGLAITRKLGFPDVIMPGDI
RNDLYLTLEKGDFERGGKSVQKNIEVTMYVLYADGEILKDCISLGSGEPNRSSYHSFVLY
HSNSPRWGEIIKLPIPIDRFRGSHLRFEFRHCSTKDKGEKKLFGFAFSTLMRDDGTTLSD
DIHELYVYKCDENSTFNNHALYLGLPCCKEDYNGCPNIPSSLIFQRSTKESFFISTQLSS
TKLTQNVDLLALLKWKAFPDRIMDVLGRLRHVSGEEIVKFLQDILDTLFVILDDNTEKYG
LLVFQSLVFIINLLRDIKYFHFRPVMDTYIQKHFAGALAYKELIRCLKWYMDCSAELIRQ
DHIQEAMRALEYLFKFIVQSRILYSRATCGMEEEQFRSSIQELFQSIRFVLSLDSRNSET
LLFTQAALLNSFPTIFDELLQMFTVQEVAEFVRGTLGSMPSTVHIGQSMDVVKLQSIART
VDSRLFSFSESRRILLPVVLHHIHLHLRQQKELLICSGILGSIFSIVKTSSLEADVMEEV
EMMVESLLDVLLQTLLTIMSKSHAQEAVRGQRCPQCTAEITGEYVSCLLSLLRQMCDTHF
QHLLDNFQSKDELKEFLLKIFCVFRNLMKMSVFPRDWMVMRLLTSNIIVTTVQYLSSALH
KNFTETDFDFKVWNSYFSLAVLFINQPSLQLEIITSAKRKKILDKYGDMRVMMAYELFSM
WQNLGEHKIHFIPGMIGPFLGVTLVPQPEVRNIMIPIFHDMMDWEQRKNGNFKQVEAELI
DKLDSMVSEGKGDESYRELFSLLTQLFGPYPSLLEKVEQETWRETGISFVTSVTRLMERL
LDYRDCMKGEETENKKIGCTVNLMNFYKSEINKEEMYIRYIHKLCDMHLQAENYTEAAFT
LLLYCELLQWEDRPLREFLHYPSQTEWQRKEGLCRKIIHYFNKGKSWEFGIPLCRELACQ
YESLYDYQSLSWIRKMEASYYDNIMEQQRLEPEFFRVGFYGRKFPFFLRNKEYVCRGHDY
ERLEAFQQRMLSEFPQAVAMQHPNHPDDAILQCDAQYLQIYAVTPIPDYVDVLQMDRVPD
RVKSFYRVNNVRKFRYDRPFHKGPKDKENEFKSLWIERTTLTLTHSLPGISRWFEVERRE
LVEVSPLENAIQVVENKNQELRSLISQYQHKQVHGNINLLSMCLNGVIDAAVNGGIARYQ
EAFFDKDYINKHPGDAEKITQLKELMQEQVHVLGVGLAVHEKFVHPEMRPLHKKLIDQFQ
MMRASLYHEFPGLDKLSPACSGTSTPRGNVLASHSPMSPESIKMTHRHSPMNLMGTGRHS
SSSLSSHASSEAGNMVMLGDGSMGDAPEDLYHHMQLAYPNPRYQGSVTNVSVLSSSQASP
SSSSLSSTHSAPSQMITSAPSSARGSPSLPDKYRHAREMMLLLPTYRDRPSSAMYPAAIL
ENGQPPNFQRALFQQVVGACKPCSDPNLSVAEKGHYSLHFDAFHHPLGDTPPALPARTLR
KSPLHPIPASPTSPQSGLDGSNSTLSGSASSGVSSLSESNFGHSSEAPPRTDTMDSMPSQ
AWNADEDLEPPYLPVHYSLSESAVLDSIKAQPCRSHSAPGCVIPQDPMDPPALPPKPYHP
RLPALEHDEGVLLREETERPRGLHRKAPLPPGSAKEEQARMAWEHGRGEQLI

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