Field Data
UniProt Accession: Q8N103
Gene Name: TAGAP
Gene Synonim: TAGAP1
GAP/GEF: GAP
Description: T-cell activation Rho GTPase-activating protein (T-cell activation GTPase-activating protein)
Keywords: Alternative splicing;Complete proteome;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 117289
Ensembl Gene ID: ENSG00000164691
Ensembl Protein ID: ENSP00000356033
Our Specificity RhoA, Rac1
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>TAGAP
atgaagctgataagcagtctcgatggttcaaaaacacttaatgctaacaacatggagaca
ttaattgaatgtcagtcagagggtgatatcaaagtgcctcccctgctgacatcatgtgag
agtgaagacagcatttgccagctaactgaaattaagaagagaaagaaagtgctgtcctgg
ccatctctcatgagaaagctctctccttcatccgacttctctgggtcattggaaccagag
ctgaaagtgtcgctgtttgaccaacccttgtcgatcatctgtggggagaacgacacactt
cccagacccatccaggacatcctcaccatcctctgccttaaaggtccttcaacggaaggg
atattcaggaaagctgccagcgagaaagcccgcaaggagctgaaggaggggcttaactgt
ggggtctccgtgaatctgaagcagctccctgtgcacctcctagctgtggtcttcaaggac
ttcctccgagggatacccctgaagctactctcctgtgatctctttgaggactggatgggc
gccctggagaagcccaccgaggaggacagaatcgaggccctgaagcaggttgctggtggc
ctcccccggcccaaccttctcctgctcaggcacttgctctacgtgctccacctcatcagc
aagaacgctgaggtcaacaagatggactccagcaacctcgccatctgcatcgggcctaac
atgctcactctgaagaacgaccagagcctgtccttccaggcccagaaggacctgaacaat
aaggttaagatcttggtggaattcctcatcgacaactgctttgagatatttggggagaac
attcggacgcgttcccgcatcacttctgacgactccctggaacacactgacagttcagac
gtgtcaactctgcagaatgactcggcctatgacagcaatgacccagatgtggagcccaca
agtggcgcagcctctcccaacaggcaactggagggtcccactcccacaatggctggtctg
gatacccggggccaacgggacacctgtgagtcaagctcagagtccagcgttagcatggta
gtcaggctgaaaagctccattgtccaacaagacaggcggttctctgaacccaacatgtca
ccctcacgagagtgcctcgtgggcccaacatccaagcaaaagctagcaaggagtgaggac
agcttcactctgtcccaggacgcctcctgttctgaaggcgatgaagctgaagatcccttt
acagaggaagtcttcccagcagtggacagcaaacccaagagacctgtggatttgaaaata
aagaattggacccaaggtttagcatctccacagggacacataaccaaagctttctccaga
tcctccccaggcgaatctttgggcagctcacctgtgccttctccatcctgccccaagaga
aacttcttcaccagacaccagagtttcacaacaaagacagacaaaaccaaaccccagaga
gaaattagaaagcactccatgtcgttttcctttgcgtctcacaagaaagtgctgccccga
acctccagcattgggtctgagaaatccaaagacttttctagagaccaactccagaaggac
ttgaggaaagagagccaactttctggcagaatcgtccaggaaaatgagtcagaaatccaa
agccaaacatctctgggcttcagcttgtctggcacctgggccctctcagtcgacaacacg
ttccagttagtggatatgaggaaaccaggaagcccaccatcttacgaagaggccatttat
taccagacatcaggactcacagcctacggtggccagacagttgggagtatgaggtcaaga
atgttcaagccaagcacagcagtgccccctgtgccttctcaccatggaggtgacctcagt
gaagggacacctggtggacacagattgtcttctgtgactgagcactggacacacagtcag
actgtccatgtctctatagaaactcaggggagatctgagctacaccagttgaggacagtg
tccgagtccatgcagaaggctaagctggactgtcttgggccacaacacagccacttagtc
tttgaggctgaccaactctgctgtgctagagaatcctacattttaatta

Protein Sequence

>TAGAP
MKLISSLDGSKTLNANNMETLIECQSEGDIKVPPLLTSCESEDSICQLTEIKKRKKVLSW
PSLMRKLSPSSDFSGSLEPELKVSLFDQPLSIICGENDTLPRPIQDILTILCLKGPSTEG
IFRKAASEKARKELKEGLNCGVSVNLKQLPVHLLAVVFKDFLRGIPLKLLSCDLFEDWMG
ALEKPTEEDRIEALKQVAGGLPRPNLLLLRHLLYVLHLISKNAEVNKMDSSNLAICIGPN
MLTLKNDQSLSFQAQKDLNNKVKILVEFLIDNCFEIFGENIRTRSRITSDDSLEHTDSSD
VSTLQNDSAYDSNDPDVEPTSGAASPNRQLEGPTPTMAGLDTRGQRDTCESSSESSVSMV
VRLKSSIVQQDRRFSEPNMSPSRECLVGPTSKQKLARSEDSFTLSQDASCSEGDEAEDPF
TEEVFPAVDSKPKRPVDLKIKNWTQGLASPQGHITKAFSRSSPGESLGSSPVPSPSCPKR
NFFTRHQSFTTKTDKTKPQREIRKHSMSFSFASHKKVLPRTSSIGSEKSKDFSRDQLQKD
LRKESQLSGRIVQENESEIQSQTSLGFSLSGTWALSVDNTFQLVDMRKPGSPPSYEEAIY
YQTSGLTAYGGQTVGSMRSRMFKPSTAVPPVPSHHGGDLSEGTPGGHRLSSVTEHWTHSQ
TVHVSIETQGRSELHQLRTVSESMQKAKLDCLGPQHSHLVFEADQLCCARESYILI

  • Gold
  • Silver
  • Bronze
  • IntAct