Field Data
UniProt Accession: Q8N1I0
Gene Name: DOCK4
Gene Synonim: KIAA0716
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 4
Keywords: Alternative splicing;Cell membrane;Cell projection;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Proto-oncogene;Reference proteome;SH3 domain;SH3-binding
Entrez ID: 9732
Ensembl Gene ID: ENSG00000128512
Ensembl Protein ID: ENSP00000404179
Our Specificity
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0005730nucleolus
GO:0005829cytosol
GO:0016020membrane
GO:0032420stereocilium
GO:0005886plasma membrane
GO:0032421stereocilium bundle
GO:0042995cell projection

Molecular Function


GO ID Description
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0017124SH3 domain binding
GO:0048365Rac GTPase binding
GO:0030165PDZ domain binding
GO:0005515protein binding
GO:0030971receptor tyrosine kinase binding

Biological Process


GO ID Description
GO:1904754positive regulation of vascular associated smooth muscle cell migration
GO:0007264small GTPase mediated signal transduction
GO:1904694negative regulation of vascular smooth muscle contraction
GO:0043547positive regulation of GTPase activity
GO:0060326cell chemotaxis

Reactome


Reactome ID Description
R-HSA-983231Factors involved in megakaryocyte development and platelet production

KEGG


Kegg ID Description
hsa04015Rap1 signaling pathway

Field Data
Localization in this study: cytosolic
Localization in the literature: plasma membrane cytosolic

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK4
atgtggatacctacggagcacgagaaatacggcgtggttattgccagtttccgaggaacc
gttccatatggcctgtcattggaaattggagatacagttcagatcctggagaagtgtgat
ggctggtacagaggatttgccttaaaaaacccaaatatcaagggtatatttccttccagc
tacgttcacttgaaaaatgcctgtgtaaagaacaaaggacaatttgaaatggttattccc
actgaagactctgttatcacagaaatgacatcaacattaagagactggggaaccatgtgg
aaacaactctatgtgcgtaatgaaggcgatctcttccaccggctgtggcacatcatgaat
gaaatcctggacctgaggcggcaggtgctggtgggccacctcacccacgaccggatgaag
gacgtgaagcgccacattactgcccggcttgactggggcaatgaacaactgggactggac
ctggtgcctaggaaagagtacgcaatggtggatccggaagacatcagcattactgagctc
taccgattgatggaacatcgacatcggaagaaagacaccccggtgcaggccagcagtcac
cacctctttgtccagatgaagagcctcatgtgttccaacctgggagaggagctggaggtc
atcttctcactctttgacagtaaagagaaccggccaatcagtgagagatttttcttgagg
ctgaatagaaacgggcttcccaaagcccctgataaaccggaacgacattgctccctcttt
gtggatttgggcagcagtgagctaagaaaggacatttatatcaccgtgcacattatccga
atcggtcgaatgggagcaggagaaaaaaagaatgcctgtagtgtccagtaccgacgaccc
tttggctgtgcagttcttagcatcgctgacctgctaacaggagagacaaaggatgacctc
attctgaaagtatacatgtgtaacacagagagtgagtggtaccaaatccatgagaacatc
atcaaaaagctgaatgcacgttataacttgactggctccaatgcaggtttagcagtttcc
ttacagctattgcacggagacattgaacaaatcagaagggaatattcatcagtattttct
catggagtatccataacaaggaagctgggattttcaaatattattatgcctggtgaaatg
aggaatgatttatatatcactattgaaaggggagaatttgagaaaggagggaagagcgtg
gccagaaatgtggaagttacgatgttcattgtagacagtagtggccaaaccctgaaggat
tttatctccttcggctctggggagccaccagccagtgagtaccactcctttgtgctttac
cataacaacagtcccaggtggtctgaactgctgaaacttcccattcctgtggataaattc
cggggtgcacacatccgcttcgagtttcggcgttgttccacaaaggagaaaggagagaag
aagttgtttgggttttcttttgtccctctgatgcaagaagatggtaggactcttccagat
ggcactcatgagctcatcgtgcataagtgtgaagaaaacacaaatcttcaggatactacc
cgctacctcaaacttcccttttccaagggcattttccttgggaataataatcaagccatg
aaggccacaaaggagtccttttgtattacatcttttctctgttccacaaaactcacacaa
aatggtgatatgcttgatcttttgaaatggagaacccacccagacaagatcactggctgt
ctctctaaattaaaagaaattgatggctcagagatagtaaagtttctgcaggatacactg
gataccttatttggaattttagatgaaaattcccaaaaatatgggtctaaagtgtttgat
tctttggttcacataataaatttgctgcaagatagcaaatttcatcattttaaacctgta
atggacacttacattgagagtcattttgctggggcacttgcatacagagatctcatcaaa
gtgctcaaatggtacgtggaccggatcacagaagcagagcggcaagagcatatccaggag
gtgctgaaggcacaagaatacatttttaagtatatagttcaatctcgaaggctgttttcc
cttgccactggtgggcaaaacgaagaggagttccgctgctgcattcaggagcttctcatg
tcagtccgtttctttctttcgcaagagagcaaagggtctggagcattatctcagtcacag
gctgtgtttctgagctctttccctgccgtgtactcagaactgttgaagctctttgatgtc
cgggaagtagccaacttggtccaggacaccctgggcagtctgccgaccatcctgcatgtg
gatgattccctgcaggccatcaaactgcagtgcattggcaaaaccgtggaaagccagctt
tataccaacccagattcccgatacattcttctgcctgtcgtgttacatcacctccacatt
cacttgcaagaacagaaggacctgatcatgtgtgcacgtatccttagcaacgtattttgt
cttatcaagaaaaatagctcagaaaaatctgtgctggaggaaatagatgtgatagtggcc
agcttgctggatattctgctgaggaccatattggagatcaccagccgacctcagccatcc
agctcagcaatgcggttccagttccaggatgtcactagaacaggctttctgaatagggag
tcttcacatggcagtactacattgagcaccttttcagtctgtgcagacacatatggaaaa
gtgcccatgacaagtagacacactggggagtttgttgcttgtctcctgtccctattacga
caaatgacagatagacattatcaacagcttcttgatagttttaatacaaaggaagaacta
agggatttcctgctgcagatatttactgtgttccgaatattgatacgcccggagatgttt
ccaaaggactggactgttatgcgcttggttgctaacaatgttattattacaacagttcta
tacctctcagatgcacttcgtaagaacttcttaaatgaaaaccttgattataagatctgg
gattcctacttttacctcgcagtcatttttataaaccagttgtgtctgcagttggagatg
ttcacaccttccaagaagaaaaaggtgttagaaaagtatggtgacatgcgggtaacaatg
ggttgtgaaattttcagcatgtggcaaaacctaggagagcacaagcttcattttatccct
gccctgattggccccttcctagaagtgaccttgataccccagccagatcttcggaatgtc
atgattccaatttttcatgatatgatggactgggagcagaggcggagtggcaactttaaa
caggtggaagccaagctaattgacaaactggatagcctgatgtcagaaggcaaaggtgac
gaaacataccgcgagctcttcaacagtataattccactatttggtccctatcctagtcta
ctaaagaaaattgagcgggaaacatggcgggaaagtggcgtttcattaattgctactgta
actcgtctaatggagaggttgttagattacagggactgcatgaaaatgggagaggtagat
ggcaaaaagattggctgcacagttagccttctgaacttctataagactgaactgaacaag
gaggagatgtatatacgctacattcacaaactctatgatctgcatctcaaagcacagaac
tttacagaagctgcatataccctcctcttatatgacgagctactggaatggtctgatcgg
cccctcagggagttcctgacctaccccatgcaaacagaatggcagcgcaaagagcacctg
cacctcaccatcatccagaactttgacagaggcaaatgttgggagaatggcattatcttg
tgccggaagattgcagagcagtatgagagttattatgactacagaaacctgagcaagatg
cggatgatggaagcctctttgtatgacaaaattatggaccagcaacgtcttgaaccagag
ttcttcagagttggattttatggaaaaaaatttccatttttcttaagaaataaggagttt
gtgtgtcgagggcatgactacgagaggctggaagccttccaacagagaatgctgaacgag
ttcccccatgccatcgccatgcagcacgccaaccagcccgatgagaccatcttccaggca
gaagctcagtatttgcagatatatgctgtgactcccattccagagagccaggaggtcctg
cagagagagggtgttccggacaacatcaaaagcttctataaagtgaatcacatctggaaa
ttccgctatgaccgaccatttcacaaaggcacaaaagataaagagaatgaattcaagagt
ctctgggtggagagaacgtcattatacttggtgcagagtttgcctggcatctctcgctgg
tttgaagtggaaaagcgtgaagtggtagaaatgagtcctctggaaaatgcaattgaagtg
ctagaaaataagaatcagcagctgaagactctgattagtcagtgtcagacaagacagatg
cagaatattaatcccctgactatgtgcctgaatggagttatagatgctgcagttaatggt
ggcgtttccaggtatcaagaggcattctttgtcaaagaatatatcttaagtcaccctgaa
gatggggagaaaattgcacgattaagagagctgatgcttgagcaggcacagattctggaa
tttggtttggccgtgcatgagaagtttgtacctcaagatatgagaccccttcacaaaaag
ctggttgaccaattctttgtgatgaagtcgagcttagggatacaggagttctctgcttgt
atgcaagccagtcctgtccattttcctaatggaagccctcgtgtgtgtagaaactcagca
cctgcttctgtgagcccagatggtaccagggtaattcctagacgcagcccgttaagttac
ccagctgtcaaccgatattcttcctcctcactgtcctcacaagcttctgctgaagtaagc
aatattacagggcaatcagaaagctctgatgaagtctttaacatgcagccaagtccatct
acctcaagcttgagttctactcactcggcttcacctaatgtgacaagttctgctccatcg
agtgccagagcttctcctttgttgtctgacaaacacaaacattcccgagaaaactcttgc
ctgtcaccaagagagagaccatgcagtgccatctatccaacacctgtggagccttcgcag
aggatgctgtttaatcatattggagacggggccttgccacgcagtgacccaaatctctct
gcacctgaaaaagctgtgaaccccacccctagcagctggagcctggacagtgggaaggaa
gccaagaacatgtcggatagtgggaaacttatctctccccctgtccctccaagacccaca
cagactgcttcaccagcaagacacacgacatcagtatccccctcgcctgccgggcgatct
ccattgaagggctctgtgcagtctttcaccccctctccagtggagtaccactcgccagga
ctcatctccaactcccctgtcttgtcgggcagctacagcagtgggatttcttctctcagc
cggtgcagcacgtcggaaacctcaggctttgaaaatcaggtgaatgaacagtcggccccc
ctgccggtgccagtgccggtgcccgtgccgagctacggcggggaggagccagtgcgcaag
gagagcaagactccgcccccgtacagcgtctacgagcggactctgcggcgccccatcccg
ctacctcacagcctctccatccccgtcacgtcggagccgcccgcgctgccccccaagcct
ctggcagcgcgatccagccacctggagaatggggcccggaggactgaccccggcccgcgg
cccaggcccctgccccgcaaggtctctcagttattaatta

Protein Sequence

>DOCK4
MWIPTEHEKYGVVIASFRGTVPYGLSLEIGDTVQILEKCDGWYRGFALKNPNIKGIFPSS
YVHLKNACVKNKGQFEMVIPTEDSVITEMTSTLRDWGTMWKQLYVRNEGDLFHRLWHIMN
EILDLRRQVLVGHLTHDRMKDVKRHITARLDWGNEQLGLDLVPRKEYAMVDPEDISITEL
YRLMEHRHRKKDTPVQASSHHLFVQMKSLMCSNLGEELEVIFSLFDSKENRPISERFFLR
LNRNGLPKAPDKPERHCSLFVDLGSSELRKDIYITVHIIRIGRMGAGEKKNACSVQYRRP
FGCAVLSIADLLTGETKDDLILKVYMCNTESEWYQIHENIIKKLNARYNLTGSNAGLAVS
LQLLHGDIEQIRREYSSVFSHGVSITRKLGFSNIIMPGEMRNDLYITIERGEFEKGGKSV
ARNVEVTMFIVDSSGQTLKDFISFGSGEPPASEYHSFVLYHNNSPRWSELLKLPIPVDKF
RGAHIRFEFRRCSTKEKGEKKLFGFSFVPLMQEDGRTLPDGTHELIVHKCEENTNLQDTT
RYLKLPFSKGIFLGNNNQAMKATKESFCITSFLCSTKLTQNGDMLDLLKWRTHPDKITGC
LSKLKEIDGSEIVKFLQDTLDTLFGILDENSQKYGSKVFDSLVHIINLLQDSKFHHFKPV
MDTYIESHFAGALAYRDLIKVLKWYVDRITEAERQEHIQEVLKAQEYIFKYIVQSRRLFS
LATGGQNEEEFRCCIQELLMSVRFFLSQESKGSGALSQSQAVFLSSFPAVYSELLKLFDV
REVANLVQDTLGSLPTILHVDDSLQAIKLQCIGKTVESQLYTNPDSRYILLPVVLHHLHI
HLQEQKDLIMCARILSNVFCLIKKNSSEKSVLEEIDVIVASLLDILLRTILEITSRPQPS
SSAMRFQFQDVTRTGFLNRESSHGSTTLSTFSVCADTYGKVPMTSRHTGEFVACLLSLLR
QMTDRHYQQLLDSFNTKEELRDFLLQIFTVFRILIRPEMFPKDWTVMRLVANNVIITTVL
YLSDALRKNFLNENLDYKIWDSYFYLAVIFINQLCLQLEMFTPSKKKKVLEKYGDMRVTM
GCEIFSMWQNLGEHKLHFIPALIGPFLEVTLIPQPDLRNVMIPIFHDMMDWEQRRSGNFK
QVEAKLIDKLDSLMSEGKGDETYRELFNSIIPLFGPYPSLLKKIERETWRESGVSLIATV
TRLMERLLDYRDCMKMGEVDGKKIGCTVSLLNFYKTELNKEEMYIRYIHKLYDLHLKAQN
FTEAAYTLLLYDELLEWSDRPLREFLTYPMQTEWQRKEHLHLTIIQNFDRGKCWENGIIL
CRKIAEQYESYYDYRNLSKMRMMEASLYDKIMDQQRLEPEFFRVGFYGKKFPFFLRNKEF
VCRGHDYERLEAFQQRMLNEFPHAIAMQHANQPDETIFQAEAQYLQIYAVTPIPESQEVL
QREGVPDNIKSFYKVNHIWKFRYDRPFHKGTKDKENEFKSLWVERTSLYLVQSLPGISRW
FEVEKREVVEMSPLENAIEVLENKNQQLKTLISQCQTRQMQNINPLTMCLNGVIDAAVNG
GVSRYQEAFFVKEYILSHPEDGEKIARLRELMLEQAQILEFGLAVHEKFVPQDMRPLHKK
LVDQFFVMKSSLGIQEFSACMQASPVHFPNGSPRVCRNSAPASVSPDGTRVIPRRSPLSY
PAVNRYSSSSLSSQASAEVSNITGQSESSDEVFNMQPSPSTSSLSSTHSASPNVTSSAPS
SARASPLLSDKHKHSRENSCLSPRERPCSAIYPTPVEPSQRMLFNHIGDGALPRSDPNLS
APEKAVNPTPSSWSLDSGKEAKNMSDSGKLISPPVPPRPTQTASPARHTTSVSPSPAGRS
PLKGSVQSFTPSPVEYHSPGLISNSPVLSGSYSSGISSLSRCSTSETSGFENQVNEQSAP
LPVPVPVPVPSYGGEEPVRKESKTPPPYSVYERTLRRPIPLPHSLSIPVTSEPPALPPKP
LAARSSHLENGARRTDPGPRPRPLPRKVSQLLI

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  • IntAct