Field Data
UniProt Accession: Q8N1W1
Gene Name: ARHGEF28
Gene Synonim: KIAA1998, RGNEF
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 28 (190 kDa guanine nucleotide exchange factor) (p190-RhoGEF) (p190RhoGEF) (Rho guanine nucleotide exchange factor)
Keywords: 3D-structure;Alternative splicing;Cell membrane;Coiled coil;Complete proteome;Cytoplasm;Differentiation;Guanine-nucleotide releasing factor;Membrane;Metal-binding;Phosphoprotein;Polymorphism;RNA-binding;Reference proteome;Zinc;Zinc-finger
Entrez ID: 64283
Ensembl Gene ID: ENSG00000214944
Ensembl Protein ID: ENSP00000441913
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016020membrane
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0046872metal ion binding
GO:0005085guanyl-nucleotide exchange factor activity
GO:0003723RNA binding

Biological Process

GO ID Description
GO:0048013ephrin receptor signaling pathway
GO:0035556intracellular signal transduction
GO:0030154cell differentiation
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-3928662EPHB-mediated forward signaling

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: focal adhesions invadopodia

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF28
atggagttgagctgcagcgaagcacctctttacgggcagatgatgatctatgcgaagttt
gacaaaaatgtgtatcttcctgaagatgctgagttttactttacttatgacggatctcat
cagcgacatgtcatgattgcagagcgcatcgaggataacgttctccagtccagcgtccca
ggccatgggcttcaggagacggtgacggtatctgtgtgcctctgctcggaaggttactct
ccggtgaccatgggctctggctcagtgacctacgtggacaacatggcttgcaggctggct
cgtctgctggtgacgcaggccaatcgcctcacagcctgcagccaccagaccctgctgacc
ccatttgccttgacggcaggagcactgcctgccttggatgaggagctcgtgctggctctg
acccatctggaattgcctctagagtggactgtgttgggaagttcttcacttgaagtatct
tctcacagagaatctcttctacacctggctatgagatggggcctggctaaactttcccag
ttcttcttgtgtctcccggggggagtccaggccttggctttacccaacgaagagggtgcc
acaccattagacttagctttacgtgaaggacactccaagctggtggaagacgtcacaaat
tttcagggcagatggtccccaagcttctcccgagtgcagctcagtgaagaagcctccttg
cattacattcactcatcggaaacgctgaccctgaccctgaaccacacagccgagcatttg
ttggaggcagatattaaactcttccggaaatacttttgggatagagcctttcttgtcaag
gcctttgagccagaagccaggccagaggaaagaacagctatgccctccagcggtgcagaa
actgaagaagagattaagaattcagtgtccagcagatcagcagctgaaaaggaagatata
aagcgtgtcaaaagcctggtggttcaacacaatgaacatgaagaccagcacagcctagat
ttggatcgctccttcgatatcctaaaaaaatccaagccgccctcgacattgcttgctgca
ggccggctttcagacatgctgaatggaggtgatgaagtctacgctaactgtatggtgatt
gatcaggttggtgatttggatatcagctatattaatatagagggaatcactgccactacc
agccctgaatccagaggttgcactctgtggcctcagagcagcaaacacacccttcctaca
gaaaccagtcccagtgtgtacccacttagtgaaaatgtcgaagggacagcacacactgaa
gcccagcagtccttcatgtcaccatcaagttcgtgtgcttccaacttgaatctttctttt
ggttggcatggatttgaaaaggaacaaagtcatctaaagaaaagaagttctagccttgat
gccttggacgccgacagtgaaggggaagggcattctgagccatcccacatctgttacact
ccagggtctcagagctcctcaagaactgggattcctagtggggatgaattggactctttt
gagactaacactgaaccggattttaatatctccagggctgaatcccttcctctatcaagt
aatctacagtcgaaggaatcactgctttctggagttcgctcacgttcttattcttgctca
tcacccaaaatttctttaggaaaaactcgtttggtgcgtgaattaacagtatgcagttca
agtgaagagcaaagagcttacagcttatcggagccaccaagagaaaacagaattcaggaa
gaagaatgggataaatacatcatacctgccaaatcagagtctgaaaaatataaagtgagt
cgaactttcagtttcctcatgaataggatgactagccctcggaataaatcaaagacaaaa
agcaaggatgccaaagataaagagaagctgaatcgacatcagtttgccccaggaacattc
tctggggttctgcagtgtttggtttgtgataaaacactcctggggaaagagtcactgcag
tgttctaactgtaatgcaaatgtgcacaaaggttgtaaagatgctgcgcctgcatgcacc
aagaaattccaagagaaatataacaagaacaaaccacagaccatccttggaaattcttca
tttagagacatcccacagcctggtctctccttgcacccttcttcctccgtgcctgttgga
ttgccgactggaaggagggagactgtgggacaggtccatccattgtccagaagtgttcca
ggcaccaccttggaaagcttcaggaggtcagccacatccttggagtctgagagtgaccat
aacagctgcagaagcaggtctcattctgatgagctgctacagtccatgggctcttctccc
tctacagagtctttcataatggaagatgttgtggattcttctctgtggagtgacctcagc
agtgatgcccaggagtttgaagcagaatcttggagtcttgtggtggatccctcattttgt
aataggcaggagaaggatgtcatcaaaagacaggatgtcatttttgagctaatgcaaaca
gagatgcatcacatccagaccctgttcatcatgtctgagatcttcaggaaaggcatgaaa
gaggagctgcagctggaccacagcaccgtggataaaattttcccctgtttagatgagttg
cttgaaatccacaggcatttcttctacagtatgaaggaacgaaggcaggaatcctgtgct
ggcagcgacaggaattttgtgatcgaccgaattggagatattttggtacaacagttttca
gaagaaaatgcaagtaaaatgaagaaaatatatggagaattctgttgccatcataaagaa
gctgttaacctctttaaagaactccagcagaataaaaagtttcagaattttattaagctc
cgaaatagtaatcttttggctcgacgccgaggaattccagaatgcattctgttggtcact
cagcgtattacaaaataccctgtcttggtggaaaggatattgcagtacacaaaggaaaga
actgaggaacataaagacttacgcaaagcgctttgcttgattaaagacatgattgcaaca
gtggatttaaaagtcaatgaatatgagaaaaaccaaaaatggcttgagatcctaaataag
attgaaaacaaaacatacacgaagctcaaaaatggacatgtgtttaggaagcaggcactg
atgagtgaagaaaggactctgttatatgatggccttgtttactggaaaactgctacaggt
cgtttcaaagatatcctagctctacttctaactgatgtgctgctctttttacaagaaaaa
gaccagaaatacatctttgcagccgttgatcagaagccatcagttatttcccttcaaaag
cttattgctagagaagttgctaatgaggagagaggaatgtttctgatcagtgcttcatct
gctggtcctgagatgtatgaaattcacaccaattccaaggaggaacgcaataactggatg
agacggatccagcaggctgtagaaagttgtcctgaagaaaaagggggaaggacaagtgaa
tctgatgaagacaagaggaaagctgaagccagagtggccaaaattcagcaatgtcaagaa
atactcactaaccaagaccaacaaatttgtgcgtatttggaggagaagctgcatatctat
gctgaacttggagaactgagcggatttgaggacgtccatctagagccccacctccttatt
aaacctgacccaggcgagcctccccaggcagcctcattactggcagcagcactgaaagaa
gctgagagcctacaagttgcagtgaaggcctcacagatgggcgccgtgagtcaatcatgt
gaggacagttgtggagactctgtcttggcggacacactcagttctcatgatgtaccagga
tcaccgactgcctcattagtcacaggagggagagaaggaagaggctgttcggatgtggat
cccgggatccagggtgtggtaaccgacttggccgtctctgatgcaggggagaaggtggaa
tgtagaaattttccaggttcttcacaatcagagattatacaagccatacagaatttaacc
cgtctcttatacagccttcaggccgccttgaccattcaggacagccacattgagatccac
aggctggttctccagcagcaggagggcctgtctctcggccactctatcctccgaggcggc
cccttgcaggaccagaagtctcgcgacgcggacaggcagcatgaggagctggccaatgtg
caccagcttcagcaccagctccagcaggagcagcggcgctggctgcgcaggtgtgagcag
cagcagcgggcgcaggcgaccagggagagctggctgcaggagcgggagcgggagtgccag
tcgcaggaggagctgctgctgcggagccggggcgagctggacctccagctccaggagtac
cagcacagcctggagcggctgagggagggccagcgcctggtggagagggagcaggcgagg
atgcgggcccagcagagcctgctgggccactggaagcacggccggcagaggagcctgccc
gcggtgctccttccgggtggccccgaggtaatggaacttaatcgatctgagagtttatgt
catgaaaactcattcttcatcaatgaagctttagtacaaatgtcatttaacactttcaac
aaactgaatccatcagttatccatcaggatgccacttaccctacaactcaatctcattct
gacttggtgaggactagtgaacatcaagtagacctcaaggtggacccttctcagccttcg
aatgtcagtcacaaactgtggacagccgctggttccggccatcagatacttcctttccat
gaaagcagcaaggattcttgtaaaaatggctccagtatgacaaagtgcagttgtacgttg
acatctcccccgggactgtggactggaaccacatctactttgaaagatttggacacctcc
cacactgagtccccaaccccccatgactcaaattcacaccgccctcaactgcaggcgttt
ataacagaagcaaagctaaatctaccgacaaggacaatgaccagacaagatggggaaact
ggagatggagccaaagaaaatattgtttacctcttaatta

Protein Sequence

>ARHGEF28
MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP
GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT
PFALTAGALPALDEELVLALTHLELPLEWTVLGSSSLEVSSHRESLLHLAMRWGLAKLSQ
FFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLSEEASL
HYIHSSETLTLTLNHTAEHLLEADIKLFRKYFWDRAFLVKAFEPEARPEERTAMPSSGAE
TEEEIKNSVSSRSAAEKEDIKRVKSLVVQHNEHEDQHSLDLDRSFDILKKSKPPSTLLAA
GRLSDMLNGGDEVYANCMVIDQVGDLDISYINIEGITATTSPESRGCTLWPQSSKHTLPT
ETSPSVYPLSENVEGTAHTEAQQSFMSPSSSCASNLNLSFGWHGFEKEQSHLKKRSSSLD
ALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNISRAESLPLSS
NLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVCSSSEEQRAYSLSEPPRENRIQE
EEWDKYIIPAKSESEKYKVSRTFSFLMNRMTSPRNKSKTKSKDAKDKEKLNRHQFAPGTF
SGVLQCLVCDKTLLGKESLQCSNCNANVHKGCKDAAPACTKKFQEKYNKNKPQTILGNSS
FRDIPQPGLSLHPSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDH
NSCRSRSHSDELLQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFC
NRQEKDVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDEL
LEIHRHFFYSMKERRQESCAGSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKE
AVNLFKELQQNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKER
TEEHKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQAL
MSEERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQK
LIAREVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSE
SDEDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLI
KPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVLADTLSSHDVPG
SPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQSEIIQAIQNLT
RLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKSRDADRQHEELANV
HQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLRSRGELDLQLQEY
QHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLPGGPEVMELNRSESLC
HENSFFINEALVQMSFNTFNKLNPSVIHQDATYPTTQSHSDLVRTSEHQVDLKVDPSQPS
NVSHKLWTAAGSGHQILPFHESSKDSCKNGSSMTKCSCTLTSPPGLWTGTTSTLKDLDTS
HTESPTPHDSNSHRPQLQAFITEAKLNLPTRTMTRQDGETGDGAKENIVYLLI

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