Field Data
UniProt Accession: Q8N264
Gene Name: ARHGAP24
Gene Synonim: FILGAP
GAP/GEF: GAP
Description: Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)
Keywords: Alternative splicing;Angiogenesis;Cell junction;Cell projection;Coiled coil;Complete proteome;Cytoplasm;Cytoskeleton;Developmental protein;Differentiation;GTPase activation;Phosphoprotein;Reference proteome
Entrez ID: 83478
Ensembl Gene ID: ENSG00000138639
Ensembl Protein ID: ENSP00000423206
Our Specificity
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0042995cell projection
GO:0005829cytosol
GO:0005912adherens junction
GO:0005925focal adhesion
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0030154cell differentiation
GO:0007165signal transduction
GO:0001525angiogenesis
GO:0007275multicellular organism development

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: actin
Localization in the literature: actin, focal adhesions plasma membrane (junctions)

Confocal Images

Card image cap

Cytochalasin D Screen Positive

Card image cap
Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP24
atggaggagaacaatgactccacggagaacccccaacaaggccaagggcggcagaatgcc
atcaagtgtgggtggctgaggaagcaaggaggctttgtcaagacttggcatactcgctgg
tttgtgctcaagggggatcagctctattatttcaaagatgaagatgaaaccaagcccttg
ggtactatttttctgcctggaaataaagtttctgagcatccctgcaatgaagagaaccca
gggaagttcctttttgaagtagttccaggaggcgatcgagatcggatgacagcaaatcat
gaaagctacctcctcatggcaagcacccagaatgatatggaagactgggtgaagtcaatc
cgccgagtcatatggggacctttcggaggaggcatttttggacagaaactggaggatact
gttcgttatgagaagagatatgggaaccgtctggctccgatgttggtggagcagtgcgtg
gactttatccgacaaagggggctgaaagaagagggtctctttcgactgccaggccaggct
aatcttgttaaggagctccaagatgcctttgactgtggggagaagccatcatttgacagc
aacacagatgtacacacggtggcatcacttcttaagctgtacctccgagaacttccagaa
ccagttattccttatgcgaagtatgaagattttttgtcatgtgccaaactgctcagcaag
gaagaggaagcaggtgttaaggaattagcaaagcaggtgaagagtttgccagtggtaaat
tacaacctcctcaagtatatttgcagattcttggatgaagtacagtcctactcgggagtt
aacaaaatgagtgtgcagaacttggcaacggtctttggtcctaatatcctgcgccccaaa
gtggaagatcctttgactatcatggagggcactgtggtggtccagcagttgatgtcagtg
atgattagcaaacatgattgcctctttcccaaagatgcagaactacaaagcaagccccaa
gatggagtgagcaacaacaatgaaattcagaagaaagccaccatggggcagttacagaac
aaggagaacaataacaccaaggacagccctagtaggcagtgctcctgggacaagtctgag
tcaccccagagaagcagcatgaacaatggatcccccacagctctatcaggcagcaaaacc
aacagcccaaagaacagtgttcacaagctagatgtgtctagaagcccccctctcatggtc
aaaaagaacccagcctttaataagggtagtgggatagttaccaatgggtccttcagcagc
agtaatgcagaaggtcttgagaaaacccaaaccacccccaatgggagcctacaggccaga
aggagctcttcactgaaggtatctggtaccaaaatgggcacgcacagtgtacagaatgga
acggtgcgcatgggcattttgaacagcgacacactcgggaaccccacaaatgttcgaaac
atgagctggctgccaaatggctatgtgaccctgagggataacaagcagaaagaacaagct
ggagagttaggccagcacaacagactgtccacctatgataatgtccatcaacagttctcc
atgatgaaccttgatgacaagcagagcattgacagtgctacctggtccacttcctcctgt
gaaatctccctccctgagaactccaactcctgtcgctcttctaccaccacctgcccagag
caagacttttttggggggaactttgaggaccctgttttggatgggcccccgcaggacgac
ctttcccaccccagggactatgaaagcaaaagtgaccacaggagtgtgggaggtcgaagt
agtcgtgccaccagtagcagtgacaacagtgagacatttgtgggcaacagcagcagcaac
cacagtgcactgcacagtttagtttccagcctgaaacaggaaatgaccaaacagaagata
gagtatgagtccaggataaagagcttagaacagcgaaacttgactttggaaacagaaatg
atgagcctccatgatgaactggatcaggagaggaaaaagttcacaatgatagaaataaaa
atgcgaaatgccgagcgagcaaaagaagatgccgagaaaagaaatgacatgctacagaaa
gaaatggagcagtttttttccacgtttggagaactgacagtggaacccaggagaaccgag
agaggaaacacaatatggattcagttaatta

Protein Sequence

>ARHGAP24
MEENNDSTENPQQGQGRQNAIKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPL
GTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSI
RRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQA
NLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSK
EEEAGVKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPK
VEDPLTIMEGTVVVQQLMSVMISKHDCLFPKDAELQSKPQDGVSNNNEIQKKATMGQLQN
KENNNTKDSPSRQCSWDKSESPQRSSMNNGSPTALSGSKTNSPKNSVHKLDVSRSPPLMV
KKNPAFNKGSGIVTNGSFSSSNAEGLEKTQTTPNGSLQARRSSSLKVSGTKMGTHSVQNG
TVRMGILNSDTLGNPTNVRNMSWLPNGYVTLRDNKQKEQAGELGQHNRLSTYDNVHQQFS
MMNLDDKQSIDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFFGGNFEDPVLDGPPQDD
LSHPRDYESKSDHRSVGGRSSRATSSSDNSETFVGNSSSNHSALHSLVSSLKQEMTKQKI
EYESRIKSLEQRNLTLETEMMSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQK
EMEQFFSTFGELTVEPRRTERGNTIWIQLI

  • Gold
  • Silver
  • Bronze
  • IntAct