Field Data
UniProt Accession: Q8N392
Gene Name: ARHGAP18
Gene Synonim:
GAP/GEF: GAP
Description: Rho GTPase-activating protein 18 (MacGAP) (Rho-type GTPase-activating protein 18)
Keywords: Alternative splicing;Complete proteome;Cytoplasm;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 93663
Ensembl Gene ID: ENSG00000146376
Ensembl Protein ID: ENSP00000357131
Our Specificity
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0016607nuclear speck
GO:0005829cytosol
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0045296cadherin binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0030833regulation of actin filament polymerization
GO:0043547positive regulation of GTPase activity
GO:0008360regulation of cell shape
GO:2000145regulation of cell motility
GO:0007165signal transduction
GO:0032956regulation of actin cytoskeleton organization
GO:0007264small GTPase mediated signal transduction

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: tubulin

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>ARHGAP18
atgaactggctatcgagttcctcgggagttgtgctaactgcttaccaccccagcggcaag
gaccaggtcgctggggacagccatgtaaagggaggcgacgaagccacctccagtcgcaga
tatggccaatacaccataaaccaagaaggctccaccaaagttcccgagaggcctccattt
gatcgatcgagttctcaggattccttggatgaatcaatggaagcctattggacagaacta
gaaaacatcaagaggtcgaatgaaaatcgccaagaaggtcaagaggccatagttgtcaaa
gaacctgatgagggagaactggaagaagaatggctcaaagaagcaggtctatccaatctt
tttggagagtctattgatgacccgcaggaaagcattctgtttttatctacactgacccgg
actcaggcagcagctgttcagaaacgggtggaaacggtctcccagaccttgaggaagaaa
aacaaacagcaccacattcgtgacgtcagagacatatttgctcaacagagagaggcacaa
gaaaaacctccagatgactcagacttgcggtcagtcagaacaaacgaaaacaaaggccaa
ggaaaagatgatcagccatctagtggggctgtcgatagcaaggagcagatctcacgggtg
cctgaggacacacctgcctctgaaacagacatcaatctggaggtgtcatttgcggagcaa
gctgtcaatcagaaagagttcagtaaggagaggacgcagaagatcagcagcaacgactct
ttgcccagtttcagactgccaaaagataaaacaggtacgacaaggattggagacttggca
ccccaagacatgaagaaagtttgctctctatccctgattgaactcactgccctgtatgat
gtgttgggcttggaattcaaacaacagaaagctgtgaaaatcaaaaccagagactctggt
ctttttggtattcctttaacgatattgttagaacaagatcaaagaaaagtgcctggaaca
cgaatacccttgatctttcaaaaactgatttctcgaattgaagaaggcagtctggaaacc
gagggcctcctacggataccaggagcagccatgagaatcaagaatctttgccaagaacta
gaagcgaaattttacgaggggactttcaattgggaaagtgtcaaacagcacgatgcggcc
agcctgctgaagctctttctgagagaattgccccagccactgctgagcatggagtatctc
aaagccttccaagctgtccagaatcttccaaccagaaaggaacagttgcaggctttgaac
ctccttgtcattcttctacctgacgcaaacagagacacactgaaggccttgcttgaattt
ctccaaagagtcatagataacaaagagaagaacaagatgacagctgggaatgtagcaatg
gtcatggccccaaatctcttcatgtgccacacgctgggcttgaagtccagtgaacagcga
gaatttgaaatggcagctgggacagcaaatgtcatgcacttattgattaggtaccagaaa
attctatggacaatccctaaatttattgtaatccaagtgaggaaacagaatattgagaat
caaaagaaggaaaggaaagccatgaagaaattgctgaagaaaatggcttatgaccgggaa
aaacatgaaaagcaagataaaactgcaaatggtgctgatgttcctcagggagtgattcga
gtgcaagctccccatctttcaaaagtttccatggcaatacagctaactgaagaactaaaa
gccagcgatgtgcttgccaggtttctcagccaagaaagtggggttgcccagacactcaag
aaaggagaagttttcctgtatgagattggaggaaatattggggaacgttgcctcgatgac
gacacacacatgaaggacttgtaccaactgaacccgaatgccgagtgggtcataaaatcc
aagccagtgttaatta

Protein Sequence

>ARHGAP18
MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPF
DRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNL
FGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQ
EKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQ
AVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYD
VLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLET
EGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYL
KAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAM
VMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIEN
QKKERKAMKKLLKKMAYDREKHEKQDKTANGADVPQGVIRVQAPHLSKVSMAIQLTEELK
ASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTHMKDLYQLNPNAEWVIKS
KPVLI

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  • IntAct