Field Data
UniProt Accession: Q8N4T4
Gene Name: ARHGEF39
Gene Synonim: C9orf100
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 39
Keywords: Alternative splicing;Cell membrane;Complete proteome;Guanine-nucleotide releasing factor;Membrane;Polymorphism;Reference proteome
Entrez ID: 84904
Ensembl Gene ID: ENSG00000137135
Ensembl Protein ID: ENSP00000436756
Our Specificity
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0016020membrane
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0030335positive regulation of cell migration
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: focal_adhesions, plasma_membrane
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF39
atggagctctcctgccccggttcgcggtgcccggtgcaagagcagcgtgcccgctgggag
cggaaacgcgcctgcaccgcccgggagctgctagagaccgagcggcgctaccaagaacag
ctggggctggtggccacgtactttttggggatcctgaaagccaaggggaccctgcgacca
cctgagcgccaggccctgtttggctcctgggagctcatctacggcgccagccaggagctg
cttccctacctggaaggaggatgctggggccaagggctggagggcttctgccgccacttg
gagctctataaccaatttgctgccaactcagagaggtcccagaccaccctgcaggagcag
ctaaagaaaaataaaggtttccggaggtttgtacggcttcaggaaggccgccctgagttt
gggggccttcagctccaggacctgctccctctgcctctgcaacggctccagcagtatgag
aatctcgtcgtagctttggctgaaaacacaggtcccaacagccctgaccatcaacagctc
acacgggctgcccgactgataagtgagactgcccagagagtccatactattggtcagaaa
cagaagaatgaccagcaccttcggcgtgtccaggctctgctcagtggacgccaggcaaag
gggctgacctcagggcgctggttcctacgccagggctggctgttagtggtgcctccccat
ggggagcctcggccccgcatgttcttcctcttcactgatgtgctcctcatggccaagcct
cggcctccactgcacctgctgcggagtggcacctttgcctgcaaggccctctaccccatg
gcccagtgtcatctcagcagggtctttggccactcaggaggcccttgtggtgggttgctc
agtctgtccttccctcatgagaagctactgcttatgtccacagaccaggaggagctgtca
cgctggtaccacagtctgacttgggctatcagcagccagaaaaacttaatta

Protein Sequence

>ARHGEF39
MELSCPGSRCPVQEQRARWERKRACTARELLETERRYQEQLGLVATYFLGILKAKGTLRP
PERQALFGSWELIYGASQELLPYLEGGCWGQGLEGFCRHLELYNQFAANSERSQTTLQEQ
LKKNKGFRRFVRLQEGRPEFGGLQLQDLLPLPLQRLQQYENLVVALAENTGPNSPDHQQL
TRAARLISETAQRVHTIGQKQKNDQHLRRVQALLSGRQAKGLTSGRWFLRQGWLLVVPPH
GEPRPRMFFLFTDVLLMAKPRPPLHLLRSGTFACKALYPMAQCHLSRVFGHSGGPCGGLL
SLSFPHEKLLLMSTDQEELSRWYHSLTWAISSQKNLI

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