Field Data
UniProt Accession: Q8N5V2
Gene Name: NGEF
Gene Synonim:
GAP/GEF: GEF
Description: Ephexin-1 (Eph-interacting exchange protein) (Neuronal guanine nucleotide exchange factor)
Keywords: Alternative splicing;Cell projection;Complete proteome;Cytoplasm;Developmental protein;Differentiation;Guanine-nucleotide releasing factor;Membrane;Neurogenesis;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 25791
Ensembl Gene ID: ENSG00000066248
Ensembl Protein ID: ENSP00000387033
Our Specificity RhoA
Literature Specificity Cdc42, RhoA, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0042995cell projection
GO:0005829cytosol
GO:0016020membrane
GO:0030426growth cone

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0007399nervous system development
GO:0030154cell differentiation
GO:0061002negative regulation of dendritic spine morphogenesis
GO:0043065positive regulation of apoptotic process
GO:0035023regulation of Rho protein signal transduction
GO:0048013ephrin receptor signaling pathway
GO:0043087regulation of GTPase activity
GO:0007275multicellular organism development

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-3928663EPHA-mediated growth cone collapse
R-HSA-193648NRAGE signals death through JNK

KEGG

Kegg ID Description
hsa04360Axon guidance
Field Data
Localization in this study: cytosolic
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>NGEF
atggagaccagggaatctgaagatttggaaaagacccggaggaaatcagcaagtgatcaa
tggaacactgataatgaaccagccaaggtgaaacctgagttactcccagaaaaagaggag
acttctcaagctgaccaggatatccaagacaaagagcctcattgccacatcccaattaag
agaaattccatcttcaatcgctccataagacgcaaaagcaaagccaaggccagagacaac
cccgaacggaacgccagctgcctggcagattcacaggacaatggaaaatctgtaaatgag
cccctgaccttgaatatcccctggagcagaacgcctccttgcagaacagcaatgcagaca
gacccaggagcccaggaaatgagtgagtcgtcctccaccccgggaaatggggccacgccc
gaggagtggccggccctggccgacagccccaccacgctcaccgaggccctgcggatgatc
caccccattcccgccgactcctggagaaacctcattgaacaaatagggctcctgtatcag
gaataccgagataaatcgactctccaagaaatcgaaaccaggaggcaacaggatgcagaa
atagaagacaataccaatgggtccccggccagtgaggacaccccggaggaggaagaagaa
gaggaggaggaggaggagccggccagcccaccagagaggaagactctgccccagatctgc
ctgctcagtaacccccactcaaggttcaacctctggcaggatcttcccgagatccggagc
agcggggtgcttgagatcctacagcctgaggagattaagctgcaggaggccatgttcgag
ctggtcacttccgaggcgtcctactacaagagtctgaacctgctcgtgtcccacttcatg
gagaacgagcggataaggaagatcctgcacccgtccgaggcgcacatcctcttctccaac
gtcctggacgtgctggctgtcagtgagcggttcctcctggagctggagcaccggatggag
gagaacatcgtcatctctgacgtgtgtgacatcgtgtaccgttatgcggctgaccacttc
tctgtctacatcacctacgtcagcaatcagacctaccaggagcggacctataagcagctg
ctccaggagaaggcagctttccgggagctgatcgcgcagctagagctcgaccccaagtgc
agggggctgcccttctcctccttcctcatcctgcctttccagaggatcacacgcctcaag
ctgttggtccagaacatcctgaagagggtagaagagaggtctgagcgggagtgcactgct
ttggatgctcacaaggagctggaaatggtggtgaaggcatgcaacgagggcgtcaggaaa
atgagccgcacggaacagatgatcagcattcagaagaagatggagttcaagatcaagtcg
gtgcccatcatctcccactcccgctggctgctgaagcagggtgagctgcagcagatgtca
ggccccaagacctcccggaccctgaggaccaagaagctcttccacgaaatttacctcttc
ctgttcaacgacctgctggtgatctgccggcagattccaggagacaagtaccaggtattt
gactcagctccgcggggactgctgcgtgtggaggagctggaggaccagggccagacgctg
gccaacgtgttcatcctgcggctgctggagaacgcagatgaccgggaggccacctacatg
ctaaaggcgtcctctcagagtgagatgaagcgttggatgacctcactggcccccaacagg
aggaccaagtttgtttcgttcacatcccggctgctggactgcccccaggtccagtgcgtg
cacccatacgtggctcagcagccagacgagctgacgctggagctcgccgacatcctcaac
atcctggacaagactgacgacgggtggatctttggcgagcgtctgcacgaccaggagaga
ggctggttccccagctccatgactgaggagatcttgaatcccaagatccggtcccagaac
ctcaaggaatgtttccgtgtccacaagatggatgaccctcagcgcagccagaacaaggac
cgcaggaagctgggcagccggaatcggcaattaatta

Protein Sequence

>NGEF
METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIK
RNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRTPPCRTAMQT
DPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQ
EYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQIC
LLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFM
ENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHF
SVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLK
LLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKS
VPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVF
DSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNR
RTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQER
GWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQLI

  • Gold
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  • Bronze
  • IntAct