Field Data
UniProt Accession: Q8NF50
Gene Name: DOCK8
Gene Synonim:
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 8
Keywords: Alternative splicing;Cell membrane;Cell projection;Chromosomal rearrangement;Complete proteome;Cytoplasm;Disease mutation;Guanine-nucleotide releasing factor;Membrane;Mental retardation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 81704
Ensembl Gene ID: ENSG00000107099
Ensembl Protein ID: ENSP00000419438
Our Specificity
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0031258lamellipodium membrane
GO:0031256leading edge membrane
GO:0005829cytosol
GO:0016020membrane
GO:0031252cell leading edge
GO:0005886plasma membrane
GO:0042995cell projection

Molecular Function


GO ID Description
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process


GO ID Description
GO:1903905positive regulation of establishment of T cell polarity
GO:0036336dendritic cell migration
GO:0043547positive regulation of GTPase activity
GO:0061485memory T cell proliferation
GO:0070233negative regulation of T cell apoptotic process
GO:0007596blood coagulation
GO:0001771immunological synapse formation
GO:0007264small GTPase mediated signal transduction
GO:1990869cellular response to chemokine
GO:2000406positive regulation of T cell migration

Reactome


Reactome ID Description
R-HSA-983231Factors involved in megakaryocyte development and platelet production

KEGG



Field Data
Localization in this study: cytosolic
Localization in the literature: plasma membrane

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK8
atgacacacctgaacagcctggatgtgcagcttgcccaggagctcggggacttcactgat
gacgacttggacgtggtgttcacgccaaaggaatgtaggactttgcagccctctttgccg
gaggaaggggttgaactggaccctcatgtcagggactgtgttcagacctacatccgtgag
tggctaatcgtgaaccggaaaaaccaaggaagtccagaaatctgtggctttaaaaagact
ggatctcgaaaagattttcacaagacgcttccgaaacagacgtttgagtcggaaaccttg
gagtgcagtgaacccgctgctcaggcaggcccccgccacttaaacgtgctgtgcgacgtg
tctgggaaaggccccgtcactgcctgtgactttgacctccgcagcctgcagcctgacaag
cggctagaaaacctcctgcagcaagtgagtgccgaggactttgagaagcagaacgaggag
gcccggaggaccaataggcaggccgagctctttgccctttacccatcagtggacgaggag
gatgctgtggaaatacgtccagtaccagaatgtcccaaggaacacctgggcaacagaata
ttggtcaagttgctgaccttgaagttcgagattgaaattgagcccctgtttgccagcatt
gccctctacgatgttaaagaaaggaaaaagatctcagaaaattttcactgtgacctgaac
tctgaccagttcaaaggatttctgcgagctcacacgccttcagtggccgcatcaagtcag
gcgagatctgcagtcttctcagtcacctacccgtcctcagacatctacctggtagtcaag
attgaaaaagtcctgcagcagggagagattggagactgtgcagagccctacacggttatc
aaagaaagtgatggtggaaagagtaaagaaaagattgaaaaactaaaactccaagctgaa
tccttctgccagcgtttggggaaataccggatgccctttgcctgggcacccataagctta
tcaagcttcttcaatgtctccacccttgagagggaggtaactgatgtggactctgtggtt
gggagaagctcagtgggtgaacggaggacattggcccaatctagaaggctttctgaaaga
gccctctccttggaggaaaatggggttggatccaacttcaaaacctccactctgagcgtt
agcagctttttcaagcaggaaggagatcgccttagcgatgaagacttattcaagttttta
gctgactacaaaagatcatcatccttacagagacgagtcaagtcaattccaggcttgcta
agactggagatttctacagctccagagatcatcaattgctgtctgactcctgaaatgctg
cccgtgaaaccctttcctgaaaaccggacacgcccgcacaaagagattttggaatttcca
acacgagaagtatatgtccctcacactgtgtacagaaaccttctctatgtctacccacag
aggctgaactttgtaaacaaactagcatcagcccggaacattacaataaagatccagttt
atgtgtggagaagatgctagcaatgcgatgccggtcatctttggaaaatccagcgggcct
gaatttctgcaggaagtgtacacagctgttacataccataataagtctcctgacttttat
gaagaagtgaaaattaagctccccgctaagctcacagtaaatcaccacctcctgttcacc
ttctaccatatcagctgtcagcagaagcaaggagcctccgtggaaactctcctgggatat
tcatggctgccaattctcttaaatgaacgtcttcaaactggatcctactgtctcccagtt
gccttggaaaaattgccacccaactactccatgcattctgctgagaaagtcccattacag
aatcctcccattaagtgggctgaaggacataagggagtatttaatattgaagtgcaagct
gtttcttctgtacacacccaggacaaccacctggagaagttcttcaccctctgccactcc
ctggagagccaggtgaccttccccatccgcgtgctggatcagaaaatcagcgagatggcg
ctggagcatgagctgaagctcagcatcatctgcctgaactcctcccgcctggagccgctc
gtgctcttcctgcacctggtgctggacaagctcttccagctgtccgtgcagcccatggtc
atcgctggccagacagccaacttctcccagtttgccttcgagtccgtggtggccatcgcc
aacagtctgcacaacagcaaggacctgagcaaggaccagcatgggaggaactgcctgctg
gcttcctacgtgcactacgtcttccgcctgccagaggtgcaaagggatgtgcccaagtca
ggcgctcccactgccctcctagaccctcggagctaccacacgtatggccgcacatcagct
gctgctgtgagttcaaagctgctgcaggcccgggtgatgagcagcagtaacccagacctc
gcggggacacactccgcagcagacgaggaagtgaagaacatcatgtcttcaaagatcgcc
gatcgcaactgcagccgaatgtcttactattgctctggcagtagtgatgctccaagttca
cctgcagccccaaggccagccagcaaaaagcatttccatgaggagcttgcccttcagatg
gtggtcagcaccggaatggtgagagaaacagtcttcaagtatgcctggttcttctttgag
cttctggtgaaaagcatggcccagcacgtacataacatggacaaacgggacagttttcgg
aggactcgtttttctgaccgtttcatggatgacataactactattgttaatgtggtcacc
tcggaaattgcagcccttttagtaaaaccacagaaggaaaatgaacaggcggaaaagatg
aacatcagcctggctttcttcttgtatgaccttctctccctcatggatcggggctttgtg
tttaacctcatcagacattattgcagccagctgtcagccaagctcagtaaccttccaacg
ctcatttccatgaggctagagttcctgagaatcctctgtagccatgagcattacctcaat
ctgaaccttttttttatgaatgctgatactgctccaacatctccttgtccttccatatct
tcccagaactcaagctcctgctccagcttccaggaccagaagatcgccagcatgttcgat
ctgacttccgagtaccgccagcagcacttcctcaccgggctcctcttcacagaactggct
gctgccctggatgccgaaggggaaggaatcagcaaagtacaaaggaaagctgtcagtgca
attcacagcctgctaagttctcacgacctggacccacgctgtgtcaaaccagaggtgaag
gtcaaaatcgccgccctttacctacctttagttggcatcattttggatgctttgccacag
ctctgtgactttacagttgcagatactcgcagataccgcaccagtggctcggatgaagaa
caagaaggagccggtgccattaaccagaatgtggctctggccatagcagggaataatttc
aatttgaaaacaagtggaatagtgctgtcttccttgccctataagcagtacaacatgctg
aacgcggacactactcgcaacctcatgatctgcttcctctggatcatgaaaaatgctgat
cagagcctcattaggaagtggattgctgacctgccatcaacgcagctcaacaggatttta
gatctacttttcatctgtgtgttatgttttgagtataagggaaaacagagttctgacaaa
gtcagtacccaagtcctgcagaagtcaagggatgtcaaggcccggctggaagaggctttg
ctccgtggggaaggggccagaggggagatgatgcgccgccgggctccagggaacgaccga
tttccaggcctaaatgaaaatttgagatggaagaaagagcagacacattggcggcaagct
aatgagaagctagataaaacaaaggccgagttagatcaagaagccttgatcagtggcaat
ctggctacagaagcacatttaatcatcctggatatgcaggaaaacattatccaggcgagc
tcggctctggactgtaaagacagcctgctgggaggtgttctgagggtgctggtgaattct
ctgaactgtgatcagagtaccacctacctgactcactgctttgcaacactccgtgctctc
atcgccaagtttggagacttactcttcgaagaggaggtggaacagtgtttcgacctatgt
caccaagtcctgcaccactgcagcagcagcatggatgtcacccggagccaagcctgtgcc
accctttacctcctcatgaggttcagttttggagccaccagtaattttgcaagagtaaag
atgcaagtaaccatgtccctggcatctttggtgggaagagcaccagactttaatgaagag
cacctgagaagatccttgaggacaattttggcctattcagaagaggacacagccatgcag
atgactccttttcccacccaggtggaggaacttctctgtaatctgaatagcatcttatat
gacacagtgaaaatgagggaatttcaggaagatcctgagatgcttatggatctcatgtac
agaattgccaagagttaccaggcatctcctgatctgcggctgacctggctccagaacatg
gcagagaaacacaccaagaagaagtgctacacggaggctgccatgtgcctggtgcacgcc
gctgcgttagtggctgagtatctgagcatgctggaggaccacagctacctgcccgtgggc
agtgtcagcttccagaatatttcttccaatgtgctggaggagtctgtggtctctgaggac
accctgtcacctgacgaggatggggtgtgcgcaggccagtacttcaccgagagtggcctg
gtaggcctcctggagcaggccgcggagctcttcagcacgggaggcttatatgagacagtt
aatgaggtctacaagctggtcatccccatcctagaagcgcatcgagaattccggaagctg
acactcactcacagcaagctgcagagagccttcgacagcatcgttaacaaggatcataag
agaatgtttggaacctacttccgagttggtttctttggatccaaatttggggatttggat
gaacaggagtttgtctacaaagagcctgcaattaccaagcttcctgagatctcacataga
ctagaggcattttatggtcaatgttttggtgcagaatttgtggaagtgattaaagactcc
actcctgtggacaaaaccaagttggatcctaacaaggcctacatacagatcacttttgtg
gagccctactttgatgagtatgagatgaaagacagggtcacatactttgagaagaatttc
aacctccggaggttcatgtacaccaccccgttcaccctggaggggcggcctcggggagag
ctgcatgagcagtacagaaggaacacagtcctgaccactatgcacgccttcccctacatc
aagaccaggatcagcgtcatccagaaggaggagtttgttttgacaccgattgaagttgcc
attgaagacatgaagaagaagaccctgcagttagcagttgccattaaccaggagccgcct
gatgcaaagatgcttcagatggtgctgcaaggctctgtgggagctactgtaaatcaggga
ccactggaagtagcccaagtgtttttggctgaaattcctgctgatccaaaactctatcga
catcacaacaagttgaggttatgctttaaggaattcatcatgagatgtggtgaagctgta
gagaaaaacaagcgtctcatcacggcagaccagagggaatatcagcaggaactcaaaaag
aactataacaagctaaaagagaacctcaggccaatgatcgagcggaaaattccagaactg
tacaagccaatattcagagttgagagtcaaaagagggactccttccacagatctagtttc
aggaaatgtgaaacccagttgtcacagggcagcttaatta

Protein Sequence

>DOCK8
MTHLNSLDVQLAQELGDFTDDDLDVVFTPKECRTLQPSLPEEGVELDPHVRDCVQTYIRE
WLIVNRKNQGSPEICGFKKTGSRKDFHKTLPKQTFESETLECSEPAAQAGPRHLNVLCDV
SGKGPVTACDFDLRSLQPDKRLENLLQQVSAEDFEKQNEEARRTNRQAELFALYPSVDEE
DAVEIRPVPECPKEHLGNRILVKLLTLKFEIEIEPLFASIALYDVKERKKISENFHCDLN
SDQFKGFLRAHTPSVAASSQARSAVFSVTYPSSDIYLVVKIEKVLQQGEIGDCAEPYTVI
KESDGGKSKEKIEKLKLQAESFCQRLGKYRMPFAWAPISLSSFFNVSTLEREVTDVDSVV
GRSSVGERRTLAQSRRLSERALSLEENGVGSNFKTSTLSVSSFFKQEGDRLSDEDLFKFL
ADYKRSSSLQRRVKSIPGLLRLEISTAPEIINCCLTPEMLPVKPFPENRTRPHKEILEFP
TREVYVPHTVYRNLLYVYPQRLNFVNKLASARNITIKIQFMCGEDASNAMPVIFGKSSGP
EFLQEVYTAVTYHNKSPDFYEEVKIKLPAKLTVNHHLLFTFYHISCQQKQGASVETLLGY
SWLPILLNERLQTGSYCLPVALEKLPPNYSMHSAEKVPLQNPPIKWAEGHKGVFNIEVQA
VSSVHTQDNHLEKFFTLCHSLESQVTFPIRVLDQKISEMALEHELKLSIICLNSSRLEPL
VLFLHLVLDKLFQLSVQPMVIAGQTANFSQFAFESVVAIANSLHNSKDLSKDQHGRNCLL
ASYVHYVFRLPEVQRDVPKSGAPTALLDPRSYHTYGRTSAAAVSSKLLQARVMSSSNPDL
AGTHSAADEEVKNIMSSKIADRNCSRMSYYCSGSSDAPSSPAAPRPASKKHFHEELALQM
VVSTGMVRETVFKYAWFFFELLVKSMAQHVHNMDKRDSFRRTRFSDRFMDDITTIVNVVT
SEIAALLVKPQKENEQAEKMNISLAFFLYDLLSLMDRGFVFNLIRHYCSQLSAKLSNLPT
LISMRLEFLRILCSHEHYLNLNLFFMNADTAPTSPCPSISSQNSSSCSSFQDQKIASMFD
LTSEYRQQHFLTGLLFTELAAALDAEGEGISKVQRKAVSAIHSLLSSHDLDPRCVKPEVK
VKIAALYLPLVGIILDALPQLCDFTVADTRRYRTSGSDEEQEGAGAINQNVALAIAGNNF
NLKTSGIVLSSLPYKQYNMLNADTTRNLMICFLWIMKNADQSLIRKWIADLPSTQLNRIL
DLLFICVLCFEYKGKQSSDKVSTQVLQKSRDVKARLEEALLRGEGARGEMMRRRAPGNDR
FPGLNENLRWKKEQTHWRQANEKLDKTKAELDQEALISGNLATEAHLIILDMQENIIQAS
SALDCKDSLLGGVLRVLVNSLNCDQSTTYLTHCFATLRALIAKFGDLLFEEEVEQCFDLC
HQVLHHCSSSMDVTRSQACATLYLLMRFSFGATSNFARVKMQVTMSLASLVGRAPDFNEE
HLRRSLRTILAYSEEDTAMQMTPFPTQVEELLCNLNSILYDTVKMREFQEDPEMLMDLMY
RIAKSYQASPDLRLTWLQNMAEKHTKKKCYTEAAMCLVHAAALVAEYLSMLEDHSYLPVG
SVSFQNISSNVLEESVVSEDTLSPDEDGVCAGQYFTESGLVGLLEQAAELFSTGGLYETV
NEVYKLVIPILEAHREFRKLTLTHSKLQRAFDSIVNKDHKRMFGTYFRVGFFGSKFGDLD
EQEFVYKEPAITKLPEISHRLEAFYGQCFGAEFVEVIKDSTPVDKTKLDPNKAYIQITFV
EPYFDEYEMKDRVTYFEKNFNLRRFMYTTPFTLEGRPRGELHEQYRRNTVLTTMHAFPYI
KTRISVIQKEEFVLTPIEVAIEDMKKKTLQLAVAINQEPPDAKMLQMVLQGSVGATVNQG
PLEVAQVFLAEIPADPKLYRHHNKLRLCFKEFIMRCGEAVEKNKRLITADQREYQQELKK
NYNKLKENLRPMIERKIPELYKPIFRVESQKRDSFHRSSFRKCETQLSQGSLI

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