Field Data
UniProt Accession: Q8TCU6
Gene Name: PREX1
Gene Synonim: KIAA1415
GAP/GEF: GEF
Description: Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)
Keywords: 3D-structure;Alternative splicing;Cell membrane;Complete proteome;Cytoplasm;Direct protein sequencing;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome;Repeat
Entrez ID: 57580
Ensembl Gene ID: ENSG00000124126
Ensembl Protein ID: ENSP00000361009
Our Specificity Rac1
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0043198dendritic shaft
GO:0005829cytosol
GO:0016020membrane
GO:0030426growth cone
GO:0005886plasma membrane
GO:0048471perinuclear region of cytoplasm

Molecular Function


GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0030676Rac guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005543phospholipid binding
GO:0005096GTPase activator activity
GO:0019899enzyme binding
GO:0005515protein binding

Biological Process


GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0030335positive regulation of cell migration
GO:0006469negative regulation of protein kinase activity
GO:0030593neutrophil chemotaxis
GO:0043547positive regulation of GTPase activity
GO:0050773regulation of dendrite development
GO:0030217T cell differentiation
GO:1900026positive regulation of substrate adhesion-dependent cell spreading
GO:0045785positive regulation of cell adhesion
GO:0042119neutrophil activation
GO:0072593reactive oxygen species metabolic process
GO:0043065positive regulation of apoptotic process
GO:0032007negative regulation of TOR signaling
GO:0030833regulation of actin filament polymerization
GO:0006801superoxide metabolic process
GO:0035023regulation of Rho protein signal transduction
GO:0030041actin filament polymerization
GO:0035556intracellular signal transduction
GO:0007186G-protein coupled receptor signaling pathway

Reactome


Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG


Kegg ID Description
hsa05167Kaposi's sarcoma-associated herpesvirus infection
hsa04062Chemokine signaling pathway

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>PREX1
atggaggcgcccagcggcagcgagcccggcggcgacggggccggggactgcgcccacccg
gacccccgggcccctggcgccgcggcgcccagctccggccccggcccgtgcgcggccgcc
cgggagtccgagcgccagctgcgcctccgcctctgcgtcctcaacgagatcttgggcacc
gagagggactacgtgggcaccttgcgcttcttgcagtcggcattcctgcatcgcatccgg
cagaacgtggccgactcagtggagaagggcctcacggaggagaatgtcaaggtcctgttc
tcgaacatcgaagacatcctggaagttcataaggatttcttggccgccttggagtattgt
ttacacccggagccgcagtctcagcatgaacttgggaatgttttcttaaaattcaaggac
aagttctgcgtgtacgaggagtattgcagcaaccatgagaaagccctgaggctgctggtg
gagctgaacaagatccctaccgtgcgcgccttccttttgagctgcatgcttctgggaggc
cggaagaccacggacatccctttggaaggctacctgttgtctccgatccagaggatctgc
aagtacccgctcctccttaaggagctggccaagaggactcccggcaagcacccagaccac
cccgcggtccagagtgccctgcaggccatgaagaccgtttgctccaacatcaatgagacc
aagcggcagatggagaagctggaagccctggagcagctgcagtcccacatcgaaggctgg
gagggttccaacctcacagacatctgcactcagctcctcctgcaagggactttgttaaag
atctctgcgggcaacatccaggaaagggccttcttcctcttcgacaaccttctcgtctac
tgcaagcggaaatccagggtcaccgggagcaagaagtccaccaagaggaccaaatccatc
aacggctccctctacatcttcaggggtcgaatcaacactgaagtcatggaggtggagaat
gtggaagatgggacagcggattaccatagcaacggctataccgtcaccaacggctggaag
atccacaacacggccaagaataagtggtttgtctgcatggccaagacggcagaggagaag
cagaagtggctggatgccatcatccgcgagcgggagcagcgcgagagcctgaagctgggc
atggagcgtgatgcctacgtcatgattgcggagaagggggagaagctgtaccacatgatg
atgaacaagaaggtgaacctcatcaaggaccgccggagaaagctgagcactgtccccaag
tgctttcttggcaatgagttcgttgcctggctcctagaaattggtgaaatcagcaagacg
gaagaaggagtcaacttgggccaagccctgttggagaatggcatcatccaccatgtttcc
gacaagcaccagttcaagaatgagcaggtgatgtatcgcttccgctacgacgatggcacc
tacaaggcccgaagtgagctggaggacatcatgtccaagggtgtgaggctttactgccgt
cttcacagcctctacaccccggtgatcaaagaccgtgattaccacctgaagacctacaag
tcagtgcttcccgggagcaagctggtggactggctgctggctcagggagactgccagact
cgggaggaggcagtggcgctcggcgtgggtctgtgcaacaatggcttcatgcaccacgtg
ctggagaagagcgagttcagggatgagtcccagtacttccgctttcatgctgacgaggag
atggaggggaccagcagcaagaacaaacagcttcgcaacgacttcaagctggtggagaac
attctggccaagcgcctgctgatcctgccccaggaggaggactatggctttgacatcgag
gagaagaacaaggctgtggtggtgaagtccgtccagaggggctcgctggctgaggtggct
ggcctgcaggtggggaggaagatctactccatcaatgaggacctggtgttcctgcggccg
ttttcagaggtggagtccatcctcaaccagtccttctgctcccgccgccctctgcgcctc
ctggtggccacgaaggccaaagagatcatcaaaatccccgaccagccggacacactgtgc
ttccagattcgtggagctgccccaccgtacgtctatgctgtggggagaggctctgaggcc
atggctgcagggctctgtgctggtcagtgcattctgaaggtcaatggcagcaacgtgatg
aacgatggtgcccctgaggtcctggagcacttccaggcattccggagtcggcgcgaagag
gccctgggcctgtaccagtggatctaccacacccatgaggatgcccaggaagcacgagcc
agtcaggaggcctccactgaggaccccagtggcgagcaggcccaggaggaagaccaggct
gattcagccttcccactgctgtccctgggtccccggctgagcctgtgtgaggacagcccc
atggtcaccctgactgtggacaacgtgcacctggaacacggcgtggtgtatgagtatgtg
agcacggcaggcgtcaggtgccatgtgctggagaagatcgtggagccccgcggctgcttc
ggcctcaccgccaagatcctcgaggcctttgctgccaatgacagcgtcttcgtggagaac
tgcaggcggctcatggccctgagcagcgccatcgtgaccatgccccactttgagttccgc
aacatctgtgacaccaagctggagagcattggccagaggattgcctgctaccaggagttt
gcagcccaactgaagagcagggtcagcccacccttcaaacaagcccccctggagccccac
ccgctgtgtggcctggacttctgccccaccaattgccacatcaacctcatggaagtgtcc
taccccaagaccaccccctcagtgggcaggtccttcagcatccgctttggacgcaaaccc
tccctcatcggccttgacccggagcaaggccacctgaaccccatgtcgtacacccagcac
tgcatcaccaccatggctgctccctcctggaagtgcttgcctgctgcagagggtgatccc
caaggccagggtctccatgatggcagcttcgggccagccagtgggacccttggtcaggaa
gaccggggcctcagcttcctactcaagcaggaggaccgtgagatccaggatgcctacctg
cagctcttcaccaagctggatgtggccctgaaggagatgaagcaatatgtcacccagatc
aacaggctgctgtccaccatcacagagcccacctcgggtgggtcctgcgacgcatccttg
gctgaggaggcctcctccctgcccctggtcagtgaagagagcgagatggacaggagtgac
catgggggcatcaagaaggtgtgcttcaaggtggccgaggaggaccaggaggactcaggc
cacgacaccatgagttatcgcgactcctacagcgagtgtaacagcaatcgagactcggtc
ctgtcctacaccagcgtgagaagtaacagctcctacttgggcagcgacgagatggggtct
ggagatgagctgccctgtgacatgcggatcccatctgacaagcaggacaagcttcatggc
tgcctggagcacctctttaaccaggtggactccatcaatgctctcctcaaggggccagtc
atgagccgggctttcgaagagaccaagcatttccctatgaaccacagcttacaagagttt
aaacagaaagaagagtgtacaatccgtggccggagcctgatccagattagcatccaggag
gacccctggaacctccccaactccatcaagaccctggtggacaacattcagagatatgtg
gaagatgggaagaaccagctgctcctggccttgctgaagtgcacagacacggagctgcag
ctgcgcagagacgcgatcttctgccaggccctggtggccgccgtgtgcaccttctccgag
cagctgctggcggccctgggctaccgctacaacaacaatggcgagtacgaggagagcagc
cgcgacgccagccgcaagtggctggagcaggtggcggccacgggcgtcctgctgcactgc
cagtccctgctctcgccagccacagtgaaggaggaacggaccatgctggaggacatctgg
gtgacgctgtcagagctggacaatgtcaccttctcctttaagcagctggacgagaactat
gtggccaacaccaacgtcttctaccacattgagggcagccggcaggcgctgaaggtcatc
ttctacctcgacagctaccacttctccaagctgccctcccgcctggagggtggggccagc
ctgaggctgcacacagcgctgttcacgaaagtgctggagaacgtggaggggctgccttct
ccaggcagccaggccgcggaggatttgcagcaggacatcaacgcgcagtccctggagaaa
gttcagcagtattaccgcaaactcagggcattttacctggagcggtctaacctgcccacg
gatgccagcaccacggcggtaaagatagaccagctgatccgccccatcaatgccctggat
gagctctgccgcctcatgaagtcctttgtccacccaaagcctggtgctgctgggagtgtg
ggcgccggcctcatccccatctcctcggagctctgctaccgcctgggggcctgccagatg
gtcatgtgtggcacaggcatgcagaggagcaccctgagcgtgtccctggagcaggcggcc
atcttggcacggagccacgggttgctgcccaagtgcatcatgcaggccacggacatcatg
cggaagcagggcccaagggtggagattctggccaaaaacctgcgagtcaaggaccagatg
ccccagggtgctccgcgcctctaccgcctctgccagccgccggtggatggggacctctta
atta

Protein Sequence

>PREX1
MEAPSGSEPGGDGAGDCAHPDPRAPGAAAPSSGPGPCAAARESERQLRLRLCVLNEILGT
ERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKDFLAALEYC
LHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELNKIPTVRAFLLSCMLLGG
RKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINET
KRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGNIQERAFFLFDNLLVY
CKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYHSNGYTVTNGWK
IHNTAKNKWFVCMAKTAEEKQKWLDAIIREREQRESLKLGMERDAYVMIAEKGEKLYHMM
MNKKVNLIKDRRRKLSTVPKCFLGNEFVAWLLEIGEISKTEEGVNLGQALLENGIIHHVS
DKHQFKNEQVMYRFRYDDGTYKARSELEDIMSKGVRLYCRLHSLYTPVIKDRDYHLKTYK
SVLPGSKLVDWLLAQGDCQTREEAVALGVGLCNNGFMHHVLEKSEFRDESQYFRFHADEE
MEGTSSKNKQLRNDFKLVENILAKRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVA
GLQVGRKIYSINEDLVFLRPFSEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLC
FQIRGAAPPYVYAVGRGSEAMAAGLCAGQCILKVNGSNVMNDGAPEVLEHFQAFRSRREE
ALGLYQWIYHTHEDAQEARASQEASTEDPSGEQAQEEDQADSAFPLLSLGPRLSLCEDSP
MVTLTVDNVHLEHGVVYEYVSTAGVRCHVLEKIVEPRGCFGLTAKILEAFAANDSVFVEN
CRRLMALSSAIVTMPHFEFRNICDTKLESIGQRIACYQEFAAQLKSRVSPPFKQAPLEPH
PLCGLDFCPTNCHINLMEVSYPKTTPSVGRSFSIRFGRKPSLIGLDPEQGHLNPMSYTQH
CITTMAAPSWKCLPAAEGDPQGQGLHDGSFGPASGTLGQEDRGLSFLLKQEDREIQDAYL
QLFTKLDVALKEMKQYVTQINRLLSTITEPTSGGSCDASLAEEASSLPLVSEESEMDRSD
HGGIKKVCFKVAEEDQEDSGHDTMSYRDSYSECNSNRDSVLSYTSVRSNSSYLGSDEMGS
GDELPCDMRIPSDKQDKLHGCLEHLFNQVDSINALLKGPVMSRAFEETKHFPMNHSLQEF
KQKEECTIRGRSLIQISIQEDPWNLPNSIKTLVDNIQRYVEDGKNQLLLALLKCTDTELQ
LRRDAIFCQALVAAVCTFSEQLLAALGYRYNNNGEYEESSRDASRKWLEQVAATGVLLHC
QSLLSPATVKEERTMLEDIWVTLSELDNVTFSFKQLDENYVANTNVFYHIEGSRQALKVI
FYLDSYHFSKLPSRLEGGASLRLHTALFTKVLENVEGLPSPGSQAAEDLQQDINAQSLEK
VQQYYRKLRAFYLERSNLPTDASTTAVKIDQLIRPINALDELCRLMKSFVHPKPGAAGSV
GAGLIPISSELCYRLGACQMVMCGTGMQRSTLSVSLEQAAILARSHGLLPKCIMQATDIM
RKQGPRVEILAKNLRVKDQMPQGAPRLYRLCQPPVDGDLLI

  • Gold
  • Silver
  • Bronze
  • IntAct