Field Data
UniProt Accession: Q8TER5
Gene Name: ARHGEF40
Gene Synonim: SOLO
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 40 (Protein SOLO)
Keywords: Alternative splicing;Coiled coil;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 55701
Ensembl Gene ID: ENSG00000165801
Ensembl Protein ID: ENSP00000298694
Our Specificity
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: basal_membrane_filaments
Localization in the literature: keratin cytosolic plasma membrane

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF40
atggagcctgagccagtggaggactgtgtgcagagcactctcgccgccctgtatccaccc
tttgaggcaacagcccccaccctgttgggccaggtgttccaggtggtggagaggacttat
cgggaggacgcactgaggtacacgctggacttcctggtaccagccaagcacctgcttgcc
aaggtccagcaggaagcctgtgcccaatacagtggattcctcttcttccatgaggggtgg
ccgctctgcctgcatgaacaggtggtggtgcagctagcagccctaccctggcaactgctg
cgcccaggagacttctatctgcaggtggtgccctcagctgcccaagcaccccgactagca
ctcaagtgtctggcccctgggggtgggcgggtgcaggaggttcctgtgcccaatgaggct
tgtgcctacctattcacacctgagtggctacaaggcatcaacaaggaccggccaacaggt
cgcctcagtacctgcctactgtctgcgccctctgggattcagcggctgccctgggctgag
ctcatctgtccacgatttgtgcacaaagagggcctcatggttggacatcagccaagtaca
ctgcccccagaactgccctctggacctccagggcttcccagccctccacttcctgaggag
gcgctgggtacccggagtcctggggatgggcacaatgcccctgtggaaggacctgagggc
gagtatgtggagctgttagaggtgacgctgcccgtgagggggagcccaacagatgctgaa
ggctccccaggcctctccagagtccggacggtacccacccgcaagggcgctggagggaag
ggccgccaccggagacaccgggcgtggatgcaccagaagggcctggggcctcggggccag
gatggagcacgcccacccggcgaggggagcagcaccggagcctcccctgagtctccccca
ggagctgaggctgtcccagaggcagcagtcttggaggtgtctgagcccccagcagaggct
gtgggagaagcctccggatcttgccccctgaggccaggggagcttagaggaggaggagga
ggaggccagggggctgaaggaccacctggtacccctcggagaacaggcaaaggaaacaga
agaaagaagcgagctgcaggtcgaggggctcttagccgaggaggggacagtgccccactg
agccctggggacaaggaagatgccagccaccaagaagcccttggcaatctgccctcacca
agtgagcacaagcttccagaatgccacctggttaaggaggaatatgaaggctcagggaag
ccagaatctgagccaaaagagctcaaaacagcaggcgagaaagagcctcagctctctgaa
gcctgtgggcctacagaagagggggccggagagagagagctggaggggccaggcctgctg
tgtatggcaggacacacaggcccagaaggccccctgtctgacactccaacacctccgctg
gagactgtgcaggaaggaaaaggggacaacattccagaagaggcccttgcagtctccgtc
tctgatcaccctgatgtagcttgggacttgatggcatctggattcctcatcctgacggga
ggggtggaccagagtgggcgagctctgctgaccattaccccaccgtgccctcctgaggag
cccccaccctcccgagacacgctgaacacaactcttcattacctccactcactgctcagg
cctgatctacagacactggggctgtccgtcctgctggaccttcgtcaggcacctccactg
cctccagcactcattcctgccttgagccaacttcaggactcaggagatcctccccttgtt
cagcggctgctgattctcattcatgatgaccttccaactgaactctgtggatttcagggt
gctgaggtgctgtcagagaatgatctgaaaagagtggccaagccagaggagctgcagtgg
gagttaggaggtcacagggacccctctcccagtcactgggtagagatacaccaggaagtg
gtaaggctatgtcgcctgtgccaaggtgtgctgggctcggtacggcaggccattgaggag
ctggagggagcagcagagccagaggaagaggaggcagtgggaatgcccaagccactgcag
aaggtgctggcagatccccggctgacggcactgcagagggatgggggggccatcctgatg
aggctgcgctccactcccagcagcaagctggagggccaaggcccagctacactgtatcag
gaagtggacgaggccattcaccagcttgtgcgcctctccaacctgcacgtgcagcagcaa
gagcagcggcagtgcctgcggcgactccagcaggtgttgcagtggctctcgggcccaggg
gaggagcagctggcaagctttgctatgcctggggacaccttgtctgccctgcaggagaca
gagctgcgattccgtgctttcagcgctgaggtccaggagcgcctggcccaggcacgggag
gccctggctctggaggagaatgccacctcccagaaggtgctggatatctttgaacagcgg
ctggagcaggttgagagtggcctccatcgggccctgcggctacagcgcttcttccagcag
gcacatgaatgggtggatgagggctttgctcggctggcaggagctgggccgggtcgggag
gctgtgctggctgcactggccctgcggcgggccccagagcccagtgccggcaccttccag
gagatgcgggccctggccctggacctgggcagcccagcagccctgcgagaatggggccgc
tgccaggcccgctgccaagagctagagaggaggatccagcaacacgtgggagaggaggcg
agcccacggggctaccgacgacggcgggcagacggtgccagcagtggaggggcccagtgg
gggccccgcagcccctcgcccagcctcagctccttgctgctccccagcagccctgggcca
cggccagccccatcccattgctccctggccccatgtggagaggactatgaggaagagggc
cctgagctggctccagaagcagagggcaggcccccaagagctgtgctgatccgaggcctg
gaggtcaccagcactgaggtggtagacaggacgtgctcaccacgggaacacgtgctgctg
ggccgggctagggggccagacggaccctggggagtaggcaccccccggatggagcgcaag
cgaagcatcagtgcccagcagcggctggtgtctgagctgattgcctgtgaacaagattac
gtggccaccttgagtgagccagtgccaccccctgggcctgagctgacgcctgaacttcgg
ggcacctgggctgctgccctgagtgcccgggaaaggcttcgcagcttccaccggacacac
tttctgcgggagcttcagggctgcgccacccaccccctacgcattggggcctgcttcctt
cgccacggggaccagttcagcctttatgcacagtacgtgaagcaccgacacaaactggag
aatggtctggctgcgctcagtcccttaagcaagggctccatggaggctggcccttacctg
ccccgagccctgcagcagcctctggaacagctgactcggtatgggcggctcctggaggag
ctcctgagggaagctgggcctgagctcagttctgagtgccgggcccttggggctgctgta
cagctgctccgggaacaagaggcccgtggcagagacctgctggccgtggaggcggtgcgt
ggctgtgagatagatctgaaggagcagggacagctcttgcatcgagaccccttcactgtc
atctgtggccgaaagaagtgccttcgccatgtctttctcttcgagcatctcctcctgttc
agcaagctcaagggccctgaaggggggtcagagatgtttgtttacaagcaggcctttaag
actgctgatatggggctgacagaaaacatcggggacagcggactctgctttgagttgtgg
tttcggcggcggcgtgcacgagaggcatacactctgcaggcaacctcaccagagatcaaa
ctcaagtggacaagttctattgcccagctgctgtggagacaggcagcccacaacaaggag
ctccgagtgcagcagatggtgtccatgggcattgggaataaacccttcctggacatcaaa
gcccttggggagcggacgctgagtgccctgctcactggaagagccgcccgcacccgggcc
tccgtggccgtgtcatcctttgagcatgccggcccctcccttcccggcctttcgccggga
gcctgctccctgcctgcccgcgtcgaggaggaggcctgggatctggacgtcaagcaaatt
tccctggccccagaaacacttgactcttctggagatgtgtccccaggaccaagaaacagc
cccagcctgcaacccccccaccctgggagcagcactcccaccctggccagtcgagggatc
ttagggctatcccgacagagtcatgctcgagccctgagtgaccccaccacgcctctgtta
atta

Protein Sequence

>ARHGEF40
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYREDALRYTLDFLVPAKHLLA
KVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLA
LKCLAPGGGRVQEVPVPNEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAE
LICPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSPPLPEEALGTRSPGDGHNAPVEGPEG
EYVELLEVTLPVRGSPTDAEGSPGLSRVRTVPTRKGAGGKGRHRRHRAWMHQKGLGPRGQ
DGARPPGEGSSTGASPESPPGAEAVPEAAVLEVSEPPAEAVGEASGSCPLRPGELRGGGG
GGQGAEGPPGTPRRTGKGNRRKKRAAGRGALSRGGDSAPLSPGDKEDASHQEALGNLPSP
SEHKLPECHLVKEEYEGSGKPESEPKELKTAGEKEPQLSEACGPTEEGAGERELEGPGLL
CMAGHTGPEGPLSDTPTPPLETVQEGKGDNIPEEALAVSVSDHPDVAWDLMASGFLILTG
GVDQSGRALLTITPPCPPEEPPPSRDTLNTTLHYLHSLLRPDLQTLGLSVLLDLRQAPPL
PPALIPALSQLQDSGDPPLVQRLLILIHDDLPTELCGFQGAEVLSENDLKRVAKPEELQW
ELGGHRDPSPSHWVEIHQEVVRLCRLCQGVLGSVRQAIEELEGAAEPEEEEAVGMPKPLQ
KVLADPRLTALQRDGGAILMRLRSTPSSKLEGQGPATLYQEVDEAIHQLVRLSNLHVQQQ
EQRQCLRRLQQVLQWLSGPGEEQLASFAMPGDTLSALQETELRFRAFSAEVQERLAQARE
ALALEENATSQKVLDIFEQRLEQVESGLHRALRLQRFFQQAHEWVDEGFARLAGAGPGRE
AVLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCQARCQELERRIQQHVGEEA
SPRGYRRRRADGASSGGAQWGPRSPSPSLSSLLLPSSPGPRPAPSHCSLAPCGEDYEEEG
PELAPEAEGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRARGPDGPWGVGTPRMERK
RSISAQQRLVSELIACEQDYVATLSEPVPPPGPELTPELRGTWAAALSARERLRSFHRTH
FLRELQGCATHPLRIGACFLRHGDQFSLYAQYVKHRHKLENGLAALSPLSKGSMEAGPYL
PRALQQPLEQLTRYGRLLEELLREAGPELSSECRALGAAVQLLREQEARGRDLLAVEAVR
GCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEHLLLFSKLKGPEGGSEMFVYKQAFK
TADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPEIKLKWTSSIAQLLWRQAAHNKE
LRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPG
ACSLPARVEEEAWDLDVKQISLAPETLDSSGDVSPGPRNSPSLQPPHPGSSTPTLASRGI
LGLSRQSHARALSDPTTPLLI

  • Gold
  • Silver
  • Bronze
  • IntAct