Field Data
UniProt Accession: Q8WUY9
Gene Name: DEPDC1B
Gene Synonim: XTP8
GAP/GEF: GAP
Description: DEP domain-containing protein 1B (HBV X-transactivated gene 8 protein) (HBV XAg-transactivated protein 8)
Keywords: Alternative splicing;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 55789
Ensembl Gene ID: ENSG00000035499
Ensembl Protein ID: ENSP00000389101
Our Specificity
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0030177positive regulation of Wnt signaling pathway
GO:0007165signal transduction
GO:0035556intracellular signal transduction
GO:0016477cell migration

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: plasma_membrane
Localization in the literature: plasma membrane

Confocal Images

Card image cap
Card image cap

Cytochalasin D Screen Negative

Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DEPDC1B
atggagcatcgcatcgtggggcccgggccgtaccgagctaccaggctgtggaatgagacc
gtggagctttttcgtgctaagatgccgttacggaaacatcgctgtcgtttcaagagctat
gagcattgtttcacagcggccgaagctgtggattggctgcatgagctgctgaggtgcagt
caaaacttcggccctgaagtgacccgcaaacaaacggtccagctgctaaaaaaattcctg
aagaatcacgttattgaagacatcaagggaaaatggggtgaggaagattttgaagacaat
cgtcacttatacagatttcctccttcttcacccctgaaaccatatccaaagaagccccca
aaccaaaaggatgttattaaatttccagaatggaatgatctcccaccaggcacttcacaa
gagaacatcccagtgaggccagttgtgatgaattctgagatgtggtacaagcgtcacagt
attgcaattggagaggtgccagcttgccgtcttgtccaccgcagacagctgacagaggcc
aatgtagaagagatatggaagtctatgacattatcatacttacagaaaattcttggcctg
gattccttagaagaagttttagacgtcaaacttgtcaattcgaagttcatcatccataat
gtatatagtgttagcaagcagggagttgttattcttgatgacaagtcaaaagaacttcct
cattgggtgctgtcagctatgaagtgtttggcaaattggcccaactgttctgatttgaag
cagcctatgtacttgggatttgaaaaagatgtctttaaaaccatagctgattactatggt
cacttgaaagagcctctacttacatttcatctttttgatgcttttgtcagtgtactgggt
ttgttacagaaggagaaagtggcagttgaagcatttcagatttgctgccttctcctacct
cctgaaaataggagaaagttacagctattgatgatgatgatggcaaggatttgcttaaac
aaagagatgccacccctgtgtgatggctttggtacccgaacactgatggttcagacattt
tcccgttgcatcttgtgttccaaggatgaagtggacttggatgagttattagctgctaga
ttggtaacgtttctgatggacaattaccaggaaattctgaaactccctttggccttgcag
acctctatagaggagcgtgtggctcatctacgaagagtccagataaaatacccaggagct
gatatggatatcactttatctgctccatcattttgccgtcaaattagtccagaggaattt
gaatatcaaagatcatatggctctcaggaacctctggcagccttgttggaggaagtcata
acagatgccaaactctccaacaaagagaaaaagaagaaactgaagcagtttcagaaatcc
tatcctgaagtctatcaagaacgatttcctacaccagaaagtgcagcacttctgtttcct
gaaaaacccaaaccgaaaccacagctgctaatgtgggcactaaagaagcctttccaacca
tttcaaagaactagaagttttcgaatgt

Protein Sequence

>DEPDC1B
MEHRIVGPGPYRATRLWNETVELFRAKMPLRKHRCRFKSYEHCFTAAEAVDWLHELLRCS
QNFGPEVTRKQTVQLLKKFLKNHVIEDIKGKWGEEDFEDNRHLYRFPPSSPLKPYPKKPP
NQKDVIKFPEWNDLPPGTSQENIPVRPVVMNSEMWYKRHSIAIGEVPACRLVHRRQLTEA
NVEEIWKSMTLSYLQKILGLDSLEEVLDVKLVNSKFIIHNVYSVSKQGVVILDDKSKELP
HWVLSAMKCLANWPNCSDLKQPMYLGFEKDVFKTIADYYGHLKEPLLTFHLFDAFVSVLG
LLQKEKVAVEAFQICCLLLPPENRRKLQLLMMMMARICLNKEMPPLCDGFGTRTLMVQTF
SRCILCSKDEVDLDELLAARLVTFLMDNYQEILKLPLALQTSIEERVAHLRRVQIKYPGA
DMDITLSAPSFCRQISPEEFEYQRSYGSQEPLAALLEEVITDAKLSNKEKKKKLKQFQKS
YPEVYQERFPTPESAALLFPEKPKPKPQLLMWALKKPFQPFQRTRSFRM

  • Gold
  • Silver
  • Bronze
  • IntAct