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Cellular Component

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GO ID	Description
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0001726	ruffle
GO:0030027	lamellipodium
GO:0005829	cytosol
GO:0016020	membrane
GO:0005886	plasma membrane
GO:0042995	cell projection

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Molecular Function

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GO ID	Description
GO:0046872	metal ion binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding

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Biological Process

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GO ID	Description
GO:0030336	negative regulation of cell migration
GO:0007010	cytoskeleton organization
GO:0016192	vesicle-mediated transport
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0035024	negative regulation of Rho protein signal transduction
GO:0008360	regulation of cell shape
GO:0007165	signal transduction
GO:0035021	negative regulation of Rac protein signal transduction

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Reactome

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Reactome ID	Description
R-HSA-194840	Rho GTPase cycle

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KEGG

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Kegg ID	Description
hsa04015	Rap1 signaling pathway
hsa04144	Endocytosis
hsa04024	cAMP signaling pathway

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Field	Data
Localization in this study:	actin
Localization in the literature:	cytosolic