Field Data
UniProt Accession: Q92502
Gene Name: STARD8
Gene Synonim: DLC3, KIAA0189
GAP/GEF: GAP
Description: StAR-related lipid transfer protein 8 (Deleted in liver cancer 3 protein) (DLC-3) (START domain-containing protein 8) (StARD8) (START-GAP3)
Keywords: Alternative splicing;Cell junction;Complete proteome;GTPase activation;Methylation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 9754
Ensembl Gene ID: ENSG00000130052
Ensembl Protein ID: ENSP00000363727
Our Specificity Cdc42, RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol
GO:0005925focal adhesion
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0008289lipid binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: focal_adhesions
Localization in the literature: focal adhesions plasma membrane (junctions) vesicles

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>STARD8
atgaccttgaataattgtgcctcgatgaaactggaggttcattttcaaagcaagcagaat
gaagactcagaagaggaagagcagtgtaccatcagtagccactgggccttccagcaggaa
agtaagtgctggtctcctatggggtcctctgatctgttggccccaccgagccctggcctg
ccagcgacctcaagctgtgagagcgtcctcaccgagcttagtgccacctctctgccagtc
atcaccgtgagcctaccacccgagccagcagacttgcccttgccaggccgtgcccccagc
tcgagtgaccggcccctcctcagccccacccagggccaggagggtccccaggacaaagcc
aagaagcgccatcgtaaccgtagcttcctcaagcaccttgaatctctgaggcggaaggaa
aagagtggcagccagcaagcagagcccaagcatagtccagccacctcagagaaggtctcc
aaagcctcatctttccgcagttgtcgtggcttcctctcagctggattttacagggccaag
aactgggccgccacctcagccggtggcagtggtgccaatactcggaaggcctgggaggcc
tggcctgtggcctcgttccggcatcctcagtggacacaccggggtgattgcctggtgcac
gttcctggggaccacaaaccaggcacattccctcgctccctgtccattgagagcctgtgt
cctgaggatggacaccgcctggcagactggcagccaggtaggcggtggggctgtgagggg
cgccggggctcctgtggctcaacgggcagccatgccagcacgtatgacaacttgcctgag
ctgtacccagctgagcctgtaatggttggggctgaggctgaagatgaagatgatgaggag
agtgggggcagctatgctcacctagacgacatcctccagcacgtgtgggggctacagcaa
cgagtagagctgtggtctcgggccatgtacccagacctggggcctggagatgaggaagag
gaggaggccacttcatcagtagaaatagccacagttgaggtcaaatgccaagctgaggct
ctcagccagatggaggttccggcccatggagagtccccagcctgggcccaggctgaagtc
cagccagcagtcctggctccggctcaggctccagctgaggctgaaccagtggcacaggaa
gaggctgaggccccggccccagccccggccccggccccagcccaggacagtgagcaggag
gcacattcaggcggggaacccacctttgcctctagcctgtctgtggaagaaggacactcc
atttctgacactgtggcctcctccagcgaacttgacagtagtgggaactccatgaatgag
gctgaggctgcggggtccctggctggactccaggcatcaatgccccgtgaacggcgcgat
tcaggtgttggggcctcacttaccagaccctgcaggaagctccgttggcatagcttccag
aactcccatcgtcccagcctcaactcagagtcgctggagatcaaccggcagtttgcaggc
cagatcaacctcctgcacaagggctcactgctgcggcttaccgcgttcatggagaagtac
actgtgccccacaagcagggctgggtctggtcaatgcccaagttcatgaggaggaacaag
accccagattaccggggacagcacgtatttggggtgccacccctcatccacgtgcagcgc
acgggccagccactgccacagagcattcagcaagccatgcgctacttgcgcagccagtgc
ctggaccaagtaggcatcttccgcaagtctggggtcaagtccaggatccagaacctgcgt
caaatgaatgagacctcgcctgacaatgtctgctacgagggccagtcagcctacgacgtg
gctgacctgctaaagcagtatttccgggacctgcctgagcccatcttcaccagcaagctc
accaccactttcctccagatctaccagctcctccccaaggatcagtggttggcagcagca
caagccgccaccttgctgctccccgatgagaaccgagaggtgctacagaccctgctctac
ttcttaagtgacattgcctctgccgaggaaaaccagatgacagcaggcaacctggcagtg
tgcctggcgccctccatcttccacctcaatgtctctaagaaggatagcccctctcccagg
atcaagagcaaacgcagcctcattggcaggccaggccctagggacctgagtgacaacatg
gcagccacccagggcctgtcgcacatgatcagtgactgcaagaaacttttccaggtgccc
caggacatggtgctgcagctgtgcagctcctacagcgcagctgagctcagccctcccggc
ccagccctggctgagctgcgtcaggcccaagctgcaggggtaagcctgagcctctacatg
gaagagaatatccaggacctgctgcgtgatgctgctgagcgcttcaagggctggatgagc
gtgccagggccccagcacacggagctggcttgcaggaaggcaccggatgggcaccccctg
cggctatggaaggcatccacagaggtggcagcccccccagctgtggtgctgcatcgtgtt
ctccgggagcgggccctctgggatgaggatctgctgcgggcccaggtgctggaagccctg
atgccgggtgtggagctgtaccactatgtcaccgacagcatggcaccccatccctgccgc
gactttgtggtgcttcggatgtggcgctctgacctgcctcgtgggggttgcctgcttgtc
tcccagtccctggatccggaacaacctgtgccagagtcgggtgtgcgagccctcatgctc
acatcccagtacctcatggagccttgcggcttgggccgctctcggctcacacacatctgc
cgggctgacctcaggggccgttctcctgactggtacaacaaagtctttggacacctgtgt
gccatggaagtggcaaagatccgggactccttccccaccctgcaggcagcgggccctgag
acaaagctgttaatta

Protein Sequence

>STARD8
MTLNNCASMKLEVHFQSKQNEDSEEEEQCTISSHWAFQQESKCWSPMGSSDLLAPPSPGL
PATSSCESVLTELSATSLPVITVSLPPEPADLPLPGRAPSSSDRPLLSPTQGQEGPQDKA
KKRHRNRSFLKHLESLRRKEKSGSQQAEPKHSPATSEKVSKASSFRSCRGFLSAGFYRAK
NWAATSAGGSGANTRKAWEAWPVASFRHPQWTHRGDCLVHVPGDHKPGTFPRSLSIESLC
PEDGHRLADWQPGRRWGCEGRRGSCGSTGSHASTYDNLPELYPAEPVMVGAEAEDEDDEE
SGGSYAHLDDILQHVWGLQQRVELWSRAMYPDLGPGDEEEEEATSSVEIATVEVKCQAEA
LSQMEVPAHGESPAWAQAEVQPAVLAPAQAPAEAEPVAQEEAEAPAPAPAPAPAQDSEQE
AHSGGEPTFASSLSVEEGHSISDTVASSSELDSSGNSMNEAEAAGSLAGLQASMPRERRD
SGVGASLTRPCRKLRWHSFQNSHRPSLNSESLEINRQFAGQINLLHKGSLLRLTAFMEKY
TVPHKQGWVWSMPKFMRRNKTPDYRGQHVFGVPPLIHVQRTGQPLPQSIQQAMRYLRSQC
LDQVGIFRKSGVKSRIQNLRQMNETSPDNVCYEGQSAYDVADLLKQYFRDLPEPIFTSKL
TTTFLQIYQLLPKDQWLAAAQAATLLLPDENREVLQTLLYFLSDIASAEENQMTAGNLAV
CLAPSIFHLNVSKKDSPSPRIKSKRSLIGRPGPRDLSDNMAATQGLSHMISDCKKLFQVP
QDMVLQLCSSYSAAELSPPGPALAELRQAQAAGVSLSLYMEENIQDLLRDAAERFKGWMS
VPGPQHTELACRKAPDGHPLRLWKASTEVAAPPAVVLHRVLRERALWDEDLLRAQVLEAL
MPGVELYHYVTDSMAPHPCRDFVVLRMWRSDLPRGGCLLVSQSLDPEQPVPESGVRALML
TSQYLMEPCGLGRSRLTHICRADLRGRSPDWYNKVFGHLCAMEVAKIRDSFPTLQAAGPE
TKLLI

  • Gold
  • Silver
  • Bronze
  • IntAct