Field Data
UniProt Accession: Q92608
Gene Name: DOCK2
Gene Synonim: KIAA0209
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 2
Keywords: 3D-structure;Acetylation;Alternative splicing;Complete proteome;Cytoplasm;Cytoskeleton;Disease mutation;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 1794
Ensembl Gene ID: ENSG00000134516
Ensembl Protein ID: ENSP00000256935
Our Specificity
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0070062extracellular exosome
GO:0005829cytosol
GO:0016020membrane
GO:0005576extracellular region
GO:0012505endomembrane system
GO:0035580specific granule lumen

Molecular Function


GO ID Description
GO:0030676Rac guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0042608T cell receptor binding
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process


GO ID Description
GO:0050766positive regulation of phagocytosis
GO:0043547positive regulation of GTPase activity
GO:0044351macropinocytosis
GO:0007010cytoskeleton organization
GO:0001766membrane raft polarization
GO:0002277myeloid dendritic cell activation involved in immune response
GO:0042098T cell proliferation
GO:0046633alpha-beta T cell proliferation
GO:0043312neutrophil degranulation
GO:0030036actin cytoskeleton organization
GO:0050690regulation of defense response to virus by virus
GO:0045059positive thymic T cell selection
GO:0042110T cell activation
GO:0001771immunological synapse formation
GO:0001768establishment of T cell polarity
GO:0045060negative thymic T cell selection
GO:0046631alpha-beta T cell activation
GO:0007264small GTPase mediated signal transduction
GO:0006935chemotaxis

Reactome


Reactome ID Description
R-HSA-6798695Neutrophil degranulation
R-HSA-983231Factors involved in megakaryocyte development and platelet production
R-HSA-164944Nef and signal transduction

KEGG


Kegg ID Description
hsa04062Chemokine signaling pathway
hsa04666Fc gamma R-mediated phagocytosis

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK2
atggccccctggcgcaaagctgacaaggagcggcacggcgtggccatatacaacttccaa
ggcagcggagccccccagctctccctgcagatcggcgatgtggtgcgaatacaggagacg
tgtggagactggtataggggatacctcataaagcacaaaatgttacagggcatttttcct
aagtcatttatccacatcaaggaagtgacagttgagaaaagaagaaatactgagaacatc
attcctgcagaaattcctctggcacaagaagtgacaacgacactttgggaatggggaagc
atctggaaacaactctatgtggccagcaaaaaggagcgttttctccaggtgcagtccatg
atgtacgatctgatggagtggaggtcccagcttctctcaggaaccttacccaaggatgag
ctgaaggaactgaagcagaaagtcacgtccaaaattgactatggcaacaaaatccttgag
cttgatttgattgtcagagatgaagacggaaatatcttggaccctgataataccagtgtc
atcagcttgttccatgcacatgaggaagcaactgataaaatcacagagcgtatcaaagaa
gaaatgtcaaaagaccagccagattatgcaatgtattcccggatctcctcatcccccacc
catagcctctatgtgtttgtgagaaactttgtgtgcagaattggggaagatgctgagctc
ttcatgtctctctacgaccccaacaagcaaacggtcataagtgagaactacctagtgcga
tggggcagccggggcttccctaaggagattgagatgctcaacaatctgaaggtggtcttc
acggatcttggaaacaaagacctcaacagggataaaatttacttgatttgtcaaatagtc
cgggtcggcaagatggatcttaaggatactggtgcaaagaagtgcacgcagggactgagg
aggccctttggggtggcagttatggatataacagacatcatcaaggggaaagcagagagt
gatgaagaaaagcagcacttcattccttttcacccggttacagctgagaatgacttccta
cacagcctgctgggcaaagtcatagcctccaagggggacagtggagggcaaggcctctgg
gtgaccatgaagatgctggtgggtgacatcattcagattcgcaaggactatccacacctg
gtggacaggaccaccgtggtggccaggaagctgggattcccagagatcatcatgccaggg
gatgtcaggaacgacatctacattactctcttacaaggtgactttgacaagtacaacaag
accacacagaggaatgtggaagtcatcatgtgtgtgtgcgcggaggatggcaaaacgctg
cctaatgcaatttgcgtgggagcaggggacaagcccatgaatgagtatcgctccgttgtg
tactatcaagtcaaacagccacgctggatggaaacagtcaaggtggctgtccctattgaa
gacatgcagaggatccatctgcgattcatgtttcgacatcggtcatctctggaatctaaa
gataaaggagaaaagaactttgccatgtcctatgtgaagctgatgaaagaagatgggact
actctacacgatggattccatgacttagttgtcctcaagggggacagcaagaagatggag
gatgccagcgcatacctgacccttccttcttatcgacaccatgtggaaaacaagggggcc
acgctgagcaggagctccagcagtgttggggggctttctgtcagctcccgggatgtgttc
tccatttccaccctggtgtgctccacaaagctcactcagaatgtgggcttgctgggtttg
ctgaagtggcgtatgaagcctcaactgctacaggagaatttagaaaagttgaagattgtg
gatggagaggaagtggtgaagtttctccaggatactctggatgccctcttcaacatcatg
atggagcattctcaaagtgatgaatatgacatcctcgtctttgatgccttgatttacata
ataggactcattgcagaccggaaatttcagcatttcaacaccgttctggaggcttacatc
caacagcatttcagtgcgaccttggcttacaagaaattgatgacagtgctgaagacttac
ttggatacctccagcagaggggagcaatgtgagccaatcctaagaacgctgaaggctttg
gaatatgtgttcaagttcattgttcggtcgaggacattattttcacagctttatgaaggc
aaagaacagatggagtttgaagaatccatgagacggctctttgaatccatcaacaatctg
atgaaaagtcaatacaaaactaccatccttttgcaggtggcggctttgaaatacatccca
tctgtcctgcatgatgtagaaatggtctttgatgcgaagttactcagccaactcctgtat
gagttctacacctgcatccctcctgtgaaactccagaagcagaaagtacagtctatgaat
gagatagtccagagcaacctctttaaaaagcaagaatgccgggacattctgcttcctgtc
atcaccaaagagctgaaggagctgctggagcagaaggatgacatgcaacaccaggtcctg
gagaggaagtactgcgttgaattgctcaacagcatcttggaagtccttagctaccaggat
gcggccttcacctaccaccatatccaggagatcatggtccagctgctgcggacagtgaac
cggacagtcatcaccatgggccgggatcacattctgattagtcactttgtggcatgtatg
acagccatcttaaaccagatgggtgaccagcactactccttctacattgagaccttccag
accagctctgaacttgtggacttcttgatggagaccttcatcatgttcaaggacctcatt
ggaaagaacgtgtaccctggagactggatggccatgagcatggttcaaaacagggtcttc
ctgagagctatcaacaagtttgcagaaaccatgaaccagaagttcctagaacacacgaac
tttgagttccagctgtggaacaactattttcatctggcagtggcttttatcacccaggat
tctctgcagctggagcagttctcacacgccaaatacaacaaaatcctgaataagtatggg
gacatgagacggctaattggcttctccatccgtgatatgtggtacaagcttggtcagaac
aaaatctgcttcatcccaggcatggtaggacctatattagagatgacacttatccctgag
gctgagctccggaaagccaccataccaatcttcttcgacatgatgctgtgtgaatatcaa
agaagtggggatttcaaaaagtttgaaaacgaaatcatcctgaagctggaccacgaggta
gaagggggccgaggcgacgagcagtacatgcagctcctggagtcaatcctgatggaatgt
gctgcagagcacccaaccattgccaagtcggtggagaacttcgtgaacctggtcaaaggc
ctcctggagaagctgctggattaccggggtgtgatgacagatgagagcaaagacaaccgc
atgagctgcaccgtgaacctgctgaatttctacaaagataacaacagggaggagatgtac
ataaggtacctgtacaaactccgcgatcttcacctggactgtgacaattacacagaggct
gcctacacgctccttctccacacctggcttctcaagtggtcggatgagcagtgtgcatca
caggtcatgcagacaggccagcagcacccccagacacaccggcagctgaaggagacgctc
tacgagaccatcataggctactttgacaaaggaaagatgtgggaagaggccataagtctg
tgcaaggagctggcggaacagtacgagatggagatctttgactatgagctgctcagccag
aacctgatccagcaggcaaaattctatgaaagcatcatgaaaatcctcaggcccaaacca
gactactttgctgttggatactacggccagggattcccctccttcctgcggaacaaagtg
ttcatctaccgcgggaaggaatatgagcgaagagaagatttccagatgcagctgatgacc
cagttccccaatgcagagaagatgaacaccacctctgccccgggagatgatgtgaagaat
gccccaggccagtatatccagtgcttcactgtccagcctgtcttggatgaacatcccagg
ttcaagaataagccagtgcctgaccagattataaacttctacaaatccaactacgtgcaa
aggttccactactcccggcccgtgcgcagggggaccgtagacccagagaatgagtttgct
tccatgtggattgagagaacctccttcgtgactgcatacaagctgccggggatcctgcgc
tggtttgaggtggtgcacatgtcgcagaccacaattagtcctctggagaatgccatagaa
accatgtccacggccaatgagaagatcctgatgatgataaaccagtaccagagtgatgag
accctccccatcaacccactctccatgctcctgaacgggattgtggaccctgctgtcatg
ggaggcttcgccaagtatgagaaggccttcttcactgaagagtatgtcagggaccaccct
gaggaccaggacaagctgacccacctcaaggacctgattgcatggcagatccccttcttg
ggagctgggattaagatccatgagaaaagggtgtcagataacttgcgacccttccatgac
cggatggaggaatgtttcaagaacctgaaaatgaaggtggagaaggagtacggtgtccga
gagatgcctgactttgacgacaggagagtgggccgtcccaggtctatgctgcgctcatac
agacagatgtccatcatctctctggcttccatgaattctgactgcagcacccccagcaag
cctacctcagagagctttgacctggaattagcatcacccaagacgccgagagtggagcag
gaggaaccgatctccccggggagcaccctgcctgaggtcaagctgcggaggtccaagaag
aggacaaagagaagcagcgtagtttttgcggatgagaaagcagctgcagagtcggacctg
aagcggctttccaggaagcatgagttcatgagtgacaccaacctctcggagcatgcggcc
atccccctcaaggcgtctgtcctctctcaaatgagctttgccagccagtccatgcctacc
atcccagccctggcgctctcagtggcaggcatccctgggttggatgaggccaacacatct
ccccgcctcagccagaccttcctccaactctcagatggtgacaagaagacactcacacgg
aagaaggtcaatcagttcttcaagacaatgctggccagcaaatcggctgaagaaggcaaa
cagatcccagactcgctgtccacggacctgttaatta

Protein Sequence

>DOCK2
MAPWRKADKERHGVAIYNFQGSGAPQLSLQIGDVVRIQETCGDWYRGYLIKHKMLQGIFP
KSFIHIKEVTVEKRRNTENIIPAEIPLAQEVTTTLWEWGSIWKQLYVASKKERFLQVQSM
MYDLMEWRSQLLSGTLPKDELKELKQKVTSKIDYGNKILELDLIVRDEDGNILDPDNTSV
ISLFHAHEEATDKITERIKEEMSKDQPDYAMYSRISSSPTHSLYVFVRNFVCRIGEDAEL
FMSLYDPNKQTVISENYLVRWGSRGFPKEIEMLNNLKVVFTDLGNKDLNRDKIYLICQIV
RVGKMDLKDTGAKKCTQGLRRPFGVAVMDITDIIKGKAESDEEKQHFIPFHPVTAENDFL
HSLLGKVIASKGDSGGQGLWVTMKMLVGDIIQIRKDYPHLVDRTTVVARKLGFPEIIMPG
DVRNDIYITLLQGDFDKYNKTTQRNVEVIMCVCAEDGKTLPNAICVGAGDKPMNEYRSVV
YYQVKQPRWMETVKVAVPIEDMQRIHLRFMFRHRSSLESKDKGEKNFAMSYVKLMKEDGT
TLHDGFHDLVVLKGDSKKMEDASAYLTLPSYRHHVENKGATLSRSSSSVGGLSVSSRDVF
SISTLVCSTKLTQNVGLLGLLKWRMKPQLLQENLEKLKIVDGEEVVKFLQDTLDALFNIM
MEHSQSDEYDILVFDALIYIIGLIADRKFQHFNTVLEAYIQQHFSATLAYKKLMTVLKTY
LDTSSRGEQCEPILRTLKALEYVFKFIVRSRTLFSQLYEGKEQMEFEESMRRLFESINNL
MKSQYKTTILLQVAALKYIPSVLHDVEMVFDAKLLSQLLYEFYTCIPPVKLQKQKVQSMN
EIVQSNLFKKQECRDILLPVITKELKELLEQKDDMQHQVLERKYCVELLNSILEVLSYQD
AAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQ
TSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTN
FEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQN
KICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEV
EGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNR
MSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCAS
QVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQ
NLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMT
QFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQ
RFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIE
TMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHP
EDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVR
EMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQ
EEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAA
IPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTR
KKVNQFFKTMLASKSAEEGKQIPDSLSTDLLI

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