Field Data
UniProt Accession: Q92619
Gene Name: ARHGAP45
Gene Synonim: HMHA1, KIAA0223
GAP/GEF: GAP
Description: Rho GTPase-activating protein 45 [Cleaved into: Minor histocompatibility antigen HA-1 (mHag HA-1)]
Keywords: 3D-structure;Alternative splicing;Cell membrane;Cell projection;Coiled coil;Complete proteome;Cytoplasm;Direct protein sequencing;GTPase activation;Membrane;Metal-binding;Phosphoprotein;Polymorphism;Reference proteome;Zinc;Zinc-finger
Entrez ID: 23526
Ensembl Gene ID: ENSG00000180448
Ensembl Protein ID: ENSP00000439601
Our Specificity
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016020membrane
GO:0035578azurophil granule lumen
GO:0005576extracellular region
GO:0005886plasma membrane
GO:0034774secretory granule lumen
GO:0042995cell projection
GO:0032587ruffle membrane

Molecular Function

GO ID Description
GO:0046872metal ion binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035556intracellular signal transduction
GO:0007165signal transduction
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043312neutrophil degranulation

Reactome

Reactome ID Description
R-HSA-6798695Neutrophil degranulation
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature:
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP45
atgttctccaggaagaaacgagagctcatgaaaaccccttccatctcgaaaaagaaccgc
gcgggaagccccagcccgcagccctcgggggagctgcccaggaaggatggggctgacgcg
gtgttccccggaccaagcctggagccgcccgctgggtcctccggcgtcaaggccacaggg
accctcaagcggcccaccagcctgagccgccacgccagcgcggctggcttccccctgtcg
ggtgctgcctcctggacactgggccggagccaccggagcccactgacagccgccagcccg
ggcgagctgcccaccgagggtgccggcccggacgtcgtcgaggacatctcccatctgctg
gcggacgtggcccgcttcgctgagggccttgagaaacttaaggagtgtgtgttgcgtgac
gacctccttgaggcccgccgcccgcgggcccacgagtgcctgggtgaggctctgcgtgtc
atgcatcagatcatctccaagtacccgctgctgaacaccgtggagacgctcaccgcagcc
ggcaccctcattgccaaggtcaaagccttccattatgagagcaacaatgatctggagaaa
caggagttcgagaaggccctggagacgattgctgtggccttcagtagcacagtgtccgag
ttcctcatgggtgaagtggacagcagcaccctcctagcagtgcctcctggggactcgagc
cagtccatggaaagcctgtatggaccgggcagtgagggcacgcctcccagcctggaagac
tgtgacgccggctgcctgcccgccgaggaggtggacgtgctgctacagcgctgtgagggg
ggcgtggatgccgcactgctgtatgccaagaacatggccaagtacatgaaggacctcatc
agctacctggagaagcggacgacgctggagatggagtttgccaagggcctgcagaagatc
gctcacaactgcagacagagcgtcatgcaggagccccacatgccgctcctgtccatctac
tcgctggccctggagcaggacctggagttcggccacagcatggtgcaggcggtgggcacc
ttgcagacccagaccttcatgcagcccctgaccctgcggcggcttgaacacgagaagcgc
aggaaggagatcaaggaggcctggcaccgtgcccagaggaagctgcaagaggcggagtcc
aacctgcgcaaggccaagcagggttacgtgcagcgctgcgaggaccacgacaaggctcgc
ttcctcgtggccaaggcggaggaggagcaggctggcagcgcgccgggagcaggcagcacg
gccaccaagaccctggacaagcggcggcggctggaggaggaggccaagaacaaggcggag
gaagctatggccacctaccgcacctgcgtggccgacgcgaagacgcagaagcaggagctg
gaggataccaaggtgacggcgctgcggcagatccaggaggtcatccggcagagcgaccaa
accatcaagtcggccacgatctcctactaccagatgatgcatatgcagacggcgccgctg
cccgtgcacttccagatgctgtgtgagagcagcaagctgtatgacccaggccagcagtac
gcctcccacgtgcgccagctgcagcgggaccaggagcccgatgtgcactacgactttgag
ccccacgtctccgccaacgcctggtcccccgtcatgcgtgcccggaagagcagcttcaac
gtgagtgatgtggcgcggccggaggctgccgggagccccccagaagaaggcgggtgcact
gagggcacacctgccaaggaccacagggccgggcgaggacaccaggttcacaagtcatgg
ccgctctcgatctcagactcggacagtgggctggaccccggccctggcgcaggggacttt
aagaagttcgagcggacgtcatccagtggtaccatgtcgtccacggaggagctggtggac
ccagacggtggagccggggcttcagcctttgagcaggctgacctcaacggcatgaccccc
gagctgccggtggccgtgcccagtggaccgttccgccacgaggggctgtccaaggcggcc
cgtactcaccggctccggaagctccgcacgcccgccaagtgccgcgagtgcaacagctac
gtctacttccagggtgctgagtgtgaagagtgctgcctggcctgccacaagaaatgtctg
gagacgctggccatacagtgcgggcacaagaagctgcaaggccgcctgcagctgttcggc
caggacttcagccacgcggcccgcagcgcccccgacggcgtgcccttcatcgtcaagaag
tgcgtctgcgagatcgagcggcgggcgctgcgcaccaagggcatctaccgggtcaatggg
gtaaagacacgcgtggagaagctgtgccaggccttcgagaacggcaaggagctggtcgag
ctgtcgcaggcctcgccccacgacatcagcaacgtcctcaagctctacctgcgtcagctt
cccgagccgctcatctccttccgcctctaccacgagctcgtagggctggccaaggacagc
ctgaaggcagaggccgaggccaaggcggcgtcccggggccggcaggacggctcggagagc
gaggcagtggcggtggccctggcaggtcggctgcgggagctcctgcgggacctgccgcct
gagaaccgggcctcgctgcagtacctgctgcgtcacctacgcaggatcgtggaggtggag
caggacaacaagatgacccccgggaacctgggcatcgtgttcgggcccacgctgcttcgg
ccacggcccaccgaggccaccgtgtccctctcctccctggtggattatccccatcaggcc
cgcgtcatcgagactctcatcgtccactacggcctggtcttcgaggaggagccggaggag
acccccgggggccaggacgagtcatccaaccagcgagctgaggtagtcgtccaggtgccg
tacctggaggcgggcgaggcggtggtctacccgctgcaggaggcggcggcggacgggtgc
agagaatcccgagttgtgtccaacgattcggactcggacctagaggaggcctccgagctg
ctgtcctcatcggaggccagtgccctgggccacctcagcttcctggagcagcagcagagc
gaggccagcctagaggtggcttctggcagccacagcggcagtgaggagcagctggaggcc
acagcccgggaggacggggacggggacgaggacggcccggcccagcagctctcaggattc
aacaccaaccagtccaacaacgtgctgcaggccccactgccccccatgaggctccgtggc
gggcggatgacactgggctcctgcagggaaaggcagccggaattcgtgttaatta

Protein Sequence

>ARHGAP45
MFSRKKRELMKTPSISKKNRAGSPSPQPSGELPRKDGADAVFPGPSLEPPAGSSGVKATG
TLKRPTSLSRHASAAGFPLSGAASWTLGRSHRSPLTAASPGELPTEGAGPDVVEDISHLL
ADVARFAEGLEKLKECVLRDDLLEARRPRAHECLGEALRVMHQIISKYPLLNTVETLTAA
GTLIAKVKAFHYESNNDLEKQEFEKALETIAVAFSSTVSEFLMGEVDSSTLLAVPPGDSS
QSMESLYGPGSEGTPPSLEDCDAGCLPAEEVDVLLQRCEGGVDAALLYAKNMAKYMKDLI
SYLEKRTTLEMEFAKGLQKIAHNCRQSVMQEPHMPLLSIYSLALEQDLEFGHSMVQAVGT
LQTQTFMQPLTLRRLEHEKRRKEIKEAWHRAQRKLQEAESNLRKAKQGYVQRCEDHDKAR
FLVAKAEEEQAGSAPGAGSTATKTLDKRRRLEEEAKNKAEEAMATYRTCVADAKTQKQEL
EDTKVTALRQIQEVIRQSDQTIKSATISYYQMMHMQTAPLPVHFQMLCESSKLYDPGQQY
ASHVRQLQRDQEPDVHYDFEPHVSANAWSPVMRARKSSFNVSDVARPEAAGSPPEEGGCT
EGTPAKDHRAGRGHQVHKSWPLSISDSDSGLDPGPGAGDFKKFERTSSSGTMSSTEELVD
PDGGAGASAFEQADLNGMTPELPVAVPSGPFRHEGLSKAARTHRLRKLRTPAKCRECNSY
VYFQGAECEECCLACHKKCLETLAIQCGHKKLQGRLQLFGQDFSHAARSAPDGVPFIVKK
CVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPHDISNVLKLYLRQL
PEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRLRELLRDLPP
ENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLSSLVDYPHQA
RVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEAVVYPLQEAAADGC
RESRVVSNDSDSDLEEASELLSSSEASALGHLSFLEQQQSEASLEVASGSHSGSEEQLEA
TAREDGDGDEDGPAQQLSGFNTNQSNNVLQAPLPPMRLRGGRMTLGSCRERQPEFVLI

  • Gold
  • Silver
  • Bronze
  • IntAct