Field Data
UniProt Accession: Q92888
Gene Name: ARHGEF1
Gene Synonim:
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 1 (115 kDa guanine nucleotide exchange factor) (p115-RhoGEF) (p115RhoGEF) (Sub1.5)
Keywords: 3D-structure;Alternative splicing;Coiled coil;Complete proteome;Cytoplasm;GTPase activation;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 9138
Ensembl Gene ID: ENSG00000076928
Ensembl Protein ID: ENSP00000367394
Our Specificity RhoA
Literature Specificity None
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016020membrane
GO:0005886plasma membrane

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005096GTPase activator activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0003723RNA binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0050771negative regulation of axonogenesis
GO:0043547positive regulation of GTPase activity
GO:0008283cell proliferation
GO:0043065positive regulation of apoptotic process
GO:0035023regulation of Rho protein signal transduction
GO:0007266Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Kegg ID Description
hsa05205Proteoglycans in cancer
hsa04270Vascular smooth muscle contraction
hsa04611Platelet activation
hsa05200Pathways in cancer
hsa04810Regulation of actin cytoskeleton
Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic focal adhesions

Confocal Images

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Cytochalasin D Screen Positive

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF1
atggaagacttcgcccgaggggcggcctccccaggcccctcccggcctggcctggttccc
gtcagcatcatcggggctgaggatgaggattttgagaacgagctggagacaaactcagaa
gagcaaaacagccagttccagagcctggagcaggtgaagcggcgcccagcccacctcatg
gccctcctgcagcacgtggccctgcagtttgagccaggacccctggttctccgggtgccg
gtccctcccaacgtcgcctttgaacttgaccgcactagggctgacctcatctccgaggat
gtccagcggcggttcgtgcaggaggtggtgcaaagccagcaggtagccgtgggccggcag
ctggaggacttccgttccaagcggctcatgggcatgacgccctgggagcaggagctggcc
cagctggaggcttgggttgggcgggaccgagccagctacgaggcccgggagcggcacgtg
gcggagcggctgctcatgcacctggaggagatgcaacataccatctctaccgacgaagaa
aagagtgctgccgtggtcaacgccattggcctgtacatgcgccaccttggggtgcggacc
aagagtggagacaagaagtcggggaggaacttcttccggaaaaaggtgatggggaaccgg
cggtcggacgagcctgccaagaccaagaaggggctgagcagcatcctggatgccgcccgc
tggaaccggggagagccccaggttccagattttcgacacctcaaagcagaggttgatgcc
gagaagccaggtgctacagaccggaagggaggcgtggggatgccctctcgggaccggaat
atcggggctcctgggcaggacacccctggagtctctctgcaccctctgtccctggacagc
ccagaccgggaaccaggtgctgacgcccccctggagctgggggactcatccccgcagggc
ccaatgagcctggagtccttggcgcccccagagagtaccgacgagggggccgaaaccgag
agccccgagcctggagatgagggggagccggggcggtcgggactggagcttgaaccagaa
gagcctcccggctggcgggaactcgtccccccagacaccctgcacagcctgcccaagagc
caggtgaagcggcaggaggtcatcagcgagctgctggtgacagaggcggcccacgtgcgc
atgctgcgggtgctgcacgacctcttcttccagcccatggcagaatgcctgttcttcccc
ttggaggagctgcagaacatcttccccagcctggacgagctcatcgaggtgcattccctg
ttcctcgatcgcctgatgaagcggaggcaggagagtggctacctcatcgaggagatcgga
gacgtgctgctggcccggtttgatggtgctgagggctcctggttccagaaaatctcctcc
cgcttctgcagccgccagtcatttgccttagagcagctcaaagccaagcaacgcaaggac
cctcggttctgtgccttcgtgcaggaagctgagagccgcccgcggtgccgccgcctgcag
ctgaaggacatgatccccacggagatgcagcggctgaccaagtaccccctgctcctgcag
agcatcgggcagaacacagaagagcccacagaacgggagaaagtggagctggcagccgag
tgctgccgggaaattctacaccacgtcaaccaagccgtgcgtgacatggaggacctgctg
aggctcaaggactatcagcggcgcctggacttgtcccaccttcggcagagcagcgaccct
atgctgagcgagttcaagaacctggacatcaccaagaagaaattggtccacgagggccca
ctgacgtggcgggtgactaaggacaaggcagtggaggtgcatgtgctgctgctggacgac
ctgctgctgctgctccagcgccaggacgagcggctgctgctcaagtcccatagccggaca
ctgacgcccacgcccgatggcaagaccatgctgcggcccgtgctgcggctcacctccgcc
atgacccgcgaggtggccaccgatcacaaagccttctacgtcctttttacctgggaccag
gaggcccagatatacgagctggtggcacagactgtgtcggagcggaaaaactggtgtgct
ctcatcactgagactgccggatccctgaaagtccctgcccctgcctctcgccctaagccc
cggcccagcccgagcagcacccgagaacccctcctcagcagctctgagaacggcaatggt
ggccgagagacgtctccagctgatgcccggaccgagagaatcctcagtgacctcctgccc
ttctgcagaccaggccccgagggccagctcgctgccacggcccttcggaaagtgctgtcc
ctgaagcagcttctgtttccggcggaggaagacaatggggcggggcctcctcgagatggg
gatggggtcccagggggcggccccctgagcccagcacggacccaggaaatccaggagaac
ctgctcagcttggaggagaccatgaagcagctggaggagttggaggaggaattttgccgc
ctgagacccctcctgtctcagcttggggggaactctgtcccccagcctggctgcacttta
atta

Protein Sequence

>ARHGEF1
MEDFARGAASPGPSRPGLVPVSIIGAEDEDFENELETNSEEQNSQFQSLEQVKRRPAHLM
ALLQHVALQFEPGPLVLRVPVPPNVAFELDRTRADLISEDVQRRFVQEVVQSQQVAVGRQ
LEDFRSKRLMGMTPWEQELAQLEAWVGRDRASYEARERHVAERLLMHLEEMQHTISTDEE
KSAAVVNAIGLYMRHLGVRTKSGDKKSGRNFFRKKVMGNRRSDEPAKTKKGLSSILDAAR
WNRGEPQVPDFRHLKAEVDAEKPGATDRKGGVGMPSRDRNIGAPGQDTPGVSLHPLSLDS
PDREPGADAPLELGDSSPQGPMSLESLAPPESTDEGAETESPEPGDEGEPGRSGLELEPE
EPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFP
LEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYLIEEIGDVLLARFDGAEGSWFQKISS
RFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQ
SIGQNTEEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDP
MLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRT
LTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCA
LITETAGSLKVPAPASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLP
FCRPGPEGQLAATALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQEN
LLSLEETMKQLEELEEEFCRLRPLLSQLGGNSVPQPGCTLI

  • Gold
  • Silver
  • Bronze
  • IntAct