Field Data
UniProt Accession: Q96DR7
Gene Name: ARHGEF26
Gene Synonim: SGEF
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)
Keywords: Alternative splicing;Cell projection;Complete proteome;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 26084
Ensembl Gene ID: ENSG00000277101
Ensembl Protein ID: ENSP00000487265
Our Specificity Cdc42
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0001726ruffle
GO:0042995cell projection
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0097178ruffle assembly
GO:0043065positive regulation of apoptotic process
GO:0035023regulation of Rho protein signal transduction
GO:0001886endothelial cell morphogenesis

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Kegg ID Description
hsa05100Bacterial invasion of epithelial cells
Field Data
Localization in this study: actin
Localization in the literature: plasma membrane

Confocal Images

Card image cap

Cytochalasin D Screen Positive

Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF26
atggacggcgagagcgaggtggatttttctagcaacagcataacccctttgtggcggagg
cggtcgattcctcagccccaccagcttctgggccggagcaagccgaggccccagtcctac
cagagccccaacgggttactaattacggatttcccggtggaggacggagggacgctctcc
gcagcgcagattcccgcccaggtgcccaccgcctcggacagcaggacggtacataggagc
cccctgcttctgggcgcccagcggagagcggtggccaatggtgggacggcatccccggag
tacagggctgcctctcctcgacttcgacggcccaagtcacccaagctccccaaagcggtg
cctggcggctccccgaaatccccagcaaatggcgcggtgaccttgcctgcgccgccgccg
ccgccggttctgcgccccccgcggactcctaacgcgcccgccccctgcacccccgaggag
gaccttactgggttgactgccagcccggtgccttcgcccactgcaaatggccttgccgct
aataacgactctcctgggtcaggttcgcagtccggccggaaggcaaaggaccccgaacgg
gggctctttcctgggccccagaaaagttcttcggaacaaaaactccccctccaaaggctg
ccctcccaggagaacgagctcctcgagaatccttccgtggttttgagtacaaacagcccc
gccgccctcaaagtggggaagcagcagatcattccgaagagtctggcctcggaaattaaa
ataagtaaatccaacaatcaaaatgtggagccccacaagagactcctcaaggtgcgcagc
atggtggagggcctaggaggacccctgggtcacgcaggggaggagagtgaggtcgataac
gacgtggatagcccagggtctctgcggagaggcttgcggtccacgtcttatcgcagggca
gtggtcagtggctttgattttgacagtcctaccagctcgaagaagaagaacagaatgtcc
cagcctgttctgaaagtggtgatggaagacaaggagaagttttccagtctgggaaggata
aagaaaaaaatgctgaaaggacaaggaacatttgatggggaagaaaatgctgtcctgtat
caaaactacaaggaaaaggcccttgacattgattctgatgaagagtcagagcccaaagaa
cagaagtcagatgaaaaaattgtgattcaccataagccattgagatccacatggagccaa
ctctctgcggtgaaaagaaagggattatctcagacagtaagccaggaggaaagaaagaga
caagaggctatctttgaagtcatatcctctgaacattcatatttactcagcttggagatc
ttgatacgaatgtttaaaaattctaaagaactgagtgatacaatgactaaaaccgagagg
caccatcttttctccaatattacagatgtctgtgaggcaagcaaaaagttctttatagag
ttggaagcaagacatcagaataatatcttcatagatgacataagtgacattgtggaaaaa
cacacagcatccacatttgacccatatgtgaaatactgcacaaatgaagtctaccaacaa
cgaacactacaaaaattgttagctaccaatccatcctttaaggaagtattgtcaaggatt
gagtcccatgaagactgtaggaacttacccatgatctcttttctcattctccccatgcag
agggtgacccgccttcccctgctgatggatactatctgtcaaaaaacacctaaggactct
ccgaagtatgaagtctgcaaaagagccttgaaggaagttagcaagttggttcgactatgc
aatgagggcgcccggaagatggaaaggactgagatgatgtacacaattaactcccagctg
gaatttaaaattaagccttttcctttagtctcctcttcccggtggttggtaaaaagaggt
gaattgacagcctatgttgaagacactgtgcttttctcaagaaggacatccaaacagcaa
gtctacttctttctctttaacgatgtgctcattatcaccaagaagaagagtgaagaaagt
tacaacgtcaatgattataccttaagagatcagctattggtggaatcttgtgacaatgaa
gagcttaattcttctccagggaagaacagctccacaatgctctattcaagacagagctct
gccagtcacctctttactctgacagtccttagtaaccacgcgaatgagaaagtggagatg
ctactaggagctgagacgcagagcgagcgagcccgctggataactgccctgggacacagc
agcgggaagccgcctgcagaccgaacctcactgacccaggtggaaatcgttaggtcattt
actgctaagcagccagatgaactctccctgcaggtggctgacgtcgtcctcatctatcaa
cgtgtcagcgatggctggtatgagggggaacgactacgagatggagaaagaggctggttt
cctatggaatgtgccaaggagataacatgtcaagctacaattgataagaatgtggagaga
atgggacgcttgctaggactggagaccaacgtgttaatta

Protein Sequence

>ARHGEF26
MDGESEVDFSSNSITPLWRRRSIPQPHQLLGRSKPRPQSYQSPNGLLITDFPVEDGGTLS
AAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAV
PGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAA
NNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSP
AALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDN
DVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRI
KKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQ
LSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTER
HHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQ
RTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDS
PKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRG
ELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYTLRDQLLVESCDNE
ELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHS
SGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWF
PMECAKEITCQATIDKNVERMGRLLGLETNVLI

  • Gold
  • Silver
  • Bronze
  • IntAct