Field Data
UniProt Accession: Q96HP0
Gene Name: DOCK6
Gene Synonim: KIAA1395
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 6
Keywords: Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Methylation;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 57572
Ensembl Gene ID: ENSG00000130158
Ensembl Protein ID: ENSP00000294618
Our Specificity
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0048471perinuclear region of cytoplasm

Molecular Function


GO ID Description
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process


GO ID Description
GO:0007596blood coagulation
GO:0007264small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity

Reactome


Reactome ID Description
R-HSA-983231Factors involved in megakaryocyte development and platelet production

KEGG



Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK6
atggctgcctccgagcgccgcgccttcgcgcacaagatcaacaggacggtggccgcagag
gtgcggaagcaggtgtcccgggaacgcagtggctccccccactccagcaggcgctgcagc
agctccctgggggtcccactgactgaagttgtcgagcccctggactttgaggatgtactt
ctgagccggccaccagatgctgagcccgggcccctcagggacctggtagaattcccagct
gatgacttggagctgctgctgcagccccgggaatgccggaccacggagcccgggatcccc
aaggatgaaaaactggatgcccaggtgagggccgcggtggagatgtatattgaggactgg
gtcattgtccacagaaggtatcagtacctgagtgcagcatacagccccgtcaccacagac
acacagcgggagcgacagaagggcctcccccgccaggtctttgagcaggatgcttctgga
gacgagaggtccggccctgaggactcgaatgactcccggcgtggctcgggctccccggaa
gacacccctcgaagcagtggtgcctctagcatcttcgacctgaggaacctggcagctgac
tcattgctgccctctctgctagagcgggcggccccagaagatgtggaccggcgcaatgaa
acccttcgacggcagcaccggcccccggccctgctcaccctctacccggcacctgacgag
gatgaagccgtggaacgctgtagccgcccagagccaccccgcgagcactttggacaaagg
atcttggtcaagtgtctgtcgctcaagttcgagattgaaattgagcccatctttgggatc
ttggctctgtatgatgtgcgggagaaaaagaagatctcggagaacttctacttcgacctg
aactcggactccatgaaggggctgcttcgggctcatggcacccaccctgccatctccacc
ctggcccgctctgccatcttctctgtgacctacccctcacctgacatcttcctggtcatc
aagttggagaaggtgcttcagcaaggggacatcagtgagtgctgtgagccttacatggtg
ttgaaagaagtggacacagccaagaacaaagagaagctagagaagctgcgcctggcggcc
gagcagttctgcacccgcctgggccgctaccgcatgcccttcgcctggacggccgtgcac
ttggccaacatcgtgagcagcgctgggcagctggaccgggactctgactcggagggcgag
cgccggccagcctggacagaccgccgccgtcgggggccccaggaccgggcgagtagtggg
gacgacgcctgcagcttctctggcttccgtccagccacgctaactgtcacaaacttcttt
aagcaggaggctgagcgactcagtgacgaggacctcttcaagttcctggctgacatgagg
cgcccgtcgtccctgctgcggcgactacgtcctgtgactgcccagctcaagatcgacatt
tctccggctcctgaaaatccccacttctgcctctcccctgagctgcttcatatcaagccc
tacccggaccccaggggccggcccaccaaggagattctggagttccccgcccgcgaagtc
tatgccccccataccagctacaggaacctgctgtacgtgtacccgcacagcctcaacttc
agcagccgccagggctccgtgcgcaaccttgctgtgcgagtgcagtacatgacaggcgag
gaccccagccaggctctgccggtcatctttggcaagtccagctgcagtgaatttacccgc
gaggccttcacaccggtggtctaccataacaagtcccccgagttctacgaggagttcaag
ctgcatcttccagcctgcgtgacagagaaccatcacctgctgttcaccttctaccatgtc
agctgccagccccggccgggcactgccctggagacacccgtgggctttacttggatccca
ctgctgcagcacgggcgcctgaggaccggccccttctgtctcccagtgtctgtggaccag
ccgccgcccagctattccgtgctcacacccgatgtggcgcttccgggcatgcgctgggtg
gacggtcacaagggcgtgttcagtgtggagctcacagccgtgtcctctgtgcacccccag
gacccctacctggacaaattcttcaccctggtgcacgtcctggaggagggagccttccca
ttccggctcaaggacactgtgctgagcgagggcaacgtggagcaggagctgcgggccagt
cttgcagcactgcgcctggccagccccgaaccccttgtggccttctcccaccacgtgctg
gacaagctcgtgcgtctggtcatcaggcccccgatcatcagtggccagattgtgaacctg
ggccgtggagcctttgaagcaatggcccatgtagtcagccttgttcaccggagcctggag
gcagcccaggatgcccgcggtcactgcccacagctggctgcctacgtccactacgccttt
cgccttcctggcactgagcccagcctcccggatggggcccctccagtgacagtgcaggct
gccacactggcccgtggctctggtcgccccgcaagcctctacctggcgcgttccaagagc
atcagcagcagcaaccctgacctcgccgtggcccctggctctgtggatgacgaggtttcc
cgcatcctggccagcaagctgcttcacgaggagctggctctgcagtgggtggtcagcagc
agtgccgtacgcgaggccatcctccagcacgcctggttcttcttccagctcatggtgaag
agtatggcgctgcacctgctgcttggccagcgactagacacaccccgcaagctgcgcttc
cccggacgcttcctggacgacatcactgccttggtgggctctgtgggcctggaggtcatc
acccgtgtccacaaggatgtggagctggccgagcacctcaacgccagcctggctttcttc
ctcagtgaccttctgtccctggtggaccggggctttgtcttcagcctggtccgggcccac
tacaagcaggtggccacgcggctccagtcgtcccctaatccagcagccctgctgaccctg
cgcatggaattcacccgcatcctgtgcagccacgagcactacgtgaccctcaacctcccc
tgctgccccctgtcacctccagcctcgccctccccctctgtgtcctccaccacctcccag
agctccaccttctccagccaagccccggaccccaaggtgaccagcatgttcgaactgagt
ggaccattccggcagcagcacttcctagctgggctcctgctgacggagctggcactggcc
ctcgaacctgaggctgaaggggcattcctgttgcacaagaaggccatcagtgctgtgcac
agcctgctatgtggccatgacactgacccccgctacgccgaggccactgtgaaggctcgt
gtggccgagctgtacctgccactgctatcgattgcacgggataccttgccacggctgcat
gactttgctgagggcccaggtcagcggtcaagactggcctcaatgcttgactcagacaca
gaaggcgaaggggacattgcgggtaccatcaacccctctgtggccatggccattgctggt
ggccccctagcccctggctcccgggccagcatctcccaggggccaccaacggcttctcgc
gcaggctgtgccctctctgctgagtcaagccggaccttgctggcgtgtgtgctgtgggtg
ctgaaaaacaccgagccggcgctcctgcagcgctgggccactgacctgacactcccccag
ctgggacgtctgttggatttgctgtacctttgcctagctgcctttgagtacaaggggaaa
aaggcctttgaacgcatcaacagcctcacattcaaaaaatctctggatatgaaggcgcgg
ctagaggaagccattctgggtaccatcggagctcgacaagaaatggttcggcgaagtcgt
gagaggagcccgtttgggaatccggagaatgtgcgctggcggaagagcgtcacacactgg
aagcaaacctcagaccgcgtggacaagaccaaggatgaaatggaacacgaggccttggtg
gaagggaacctggcaaccgaggcaagcctagtggttctggacacactggagatcatcgtg
cagacggtgatgctttcagaagcccgggagagcgtcttgggggcagtgctgaaggttgtg
ctgtacagcctgggcagtgcccagagtgccctcttcttgcagcatggcctggccacccag
agggcccttgtgtccaagttcccggagctgctgttcgaggaggacacggagctgtgtgcc
gacctgtgcctgaggctcctacgacactgtggcagccgcatcagcaccatccgcacgcac
gccagcgcctcgctgtacctgctcatgcgacagaacttcgagatcggccacaactttgcc
cgtgtgaagatgcaggtcaccatgtctctctcgtccctggtggggacgacgcagaacttc
agtgaagagcacctgcgacgttcactcaaaaccatcctcacctatgctgaggaggacatg
gggctgcgggacagcaccttcgcagagcaggtccaggacctgatgttcaacctgcacatg
atcctgacggacacggtgaagatgaaggaacaccaggaggaccctgagatgctcatcgac
ctcatgtacagaattgcccggggctaccagggctcaccggaccttcggctgacctggttg
cagaacatggccgggaagcacgcggagctgggcaaccacgccgaggccgcccagtgcatg
gtgcacgcggccgccctcgtggctgagtacctcgccctgctcgaggaccaccgccacctg
cccgtgggctgcgtttccttccagaacatctcatccaacgtgctagaggagtccgccatc
tccgacgacatcctgtcgcccgacgaggagggcttctgctccgggaagcacttcactgag
ctggggctggtagggttgctggaacaggcagccggctacttcaccatgggcgggctctac
gaggcggtgaatgaggtctacaagaacctcatccccatcctggaagcccaccgtgactac
aagaagctggccgcggtgcacggcaaactgcaggaggccttcaccaagatcatgcaccag
agttccggctgggagcgcgtgttcgggacgtatttccgcgtgggcttctacggcgcccac
ttcggtgacctggatgagcaggagtttgtgtacaaggagccatcgatcacgaagctggca
gagatctcacaccggctggaggagttctacacggagagatttggcgacgacgtcgttgag
attatcaaagactctaaccctgtggacaagtccaagcttgactcacaaaaggcctacatc
cagatcacgtatgtggaaccgtactttgatacctacgagctcaaggaccgggtgacctac
tttgaccgcaactatgggcttcgcacattcctgttctgcacgccgttcacgccggatggg
cgcgcacacggggagctgcccgagcaacacaagcgtaagacgctgctcagcaccgaccac
gccttcccctacatcaagactcgcatccgtgtgtgccaccgggaggagacggtgctgacg
ccagtggaggtggccatcgaggacatgcagaagaagacacgggagctggcctttgccacc
gagcaggacccaccagatgctaagatgctacagatggtgcttcagggctctgtagggccc
accgtgaaccagggtcccctggaggtggcccaggtgtttttagcagagatcccggaagac
cccaagctcttccggcatcacaacaaattgcggctctgcttcaaggacttctgcaagaaa
tgtgaggatgcgctgcggaaaaataaggccctgattgggccggaccagaaggagtaccac
cgtgagctggagcgcaactactgccgcctgcgggaggctctgcagcccctgcttacccag
cgcctgccccagctgatggcacccaccccacccggcctcaggaactccttgaacagagca
agtttccgaaaggcagacctcttaattaa

Protein Sequence

>DOCK6
MAASERRAFAHKINRTVAAEVRKQVSRERSGSPHSSRRCSSSLGVPLTEVVEPLDFEDVL
LSRPPDAEPGPLRDLVEFPADDLELLLQPRECRTTEPGIPKDEKLDAQVRAAVEMYIEDW
VIVHRRYQYLSAAYSPVTTDTQRERQKGLPRQVFEQDASGDERSGPEDSNDSRRGSGSPE
DTPRSSGASSIFDLRNLAADSLLPSLLERAAPEDVDRRNETLRRQHRPPALLTLYPAPDE
DEAVERCSRPEPPREHFGQRILVKCLSLKFEIEIEPIFGILALYDVREKKKISENFYFDL
NSDSMKGLLRAHGTHPAISTLARSAIFSVTYPSPDIFLVIKLEKVLQQGDISECCEPYMV
LKEVDTAKNKEKLEKLRLAAEQFCTRLGRYRMPFAWTAVHLANIVSSAGQLDRDSDSEGE
RRPAWTDRRRRGPQDRASSGDDACSFSGFRPATLTVTNFFKQEAERLSDEDLFKFLADMR
RPSSLLRRLRPVTAQLKIDISPAPENPHFCLSPELLHIKPYPDPRGRPTKEILEFPAREV
YAPHTSYRNLLYVYPHSLNFSSRQGSVRNLAVRVQYMTGEDPSQALPVIFGKSSCSEFTR
EAFTPVVYHNKSPEFYEEFKLHLPACVTENHHLLFTFYHVSCQPRPGTALETPVGFTWIP
LLQHGRLRTGPFCLPVSVDQPPPSYSVLTPDVALPGMRWVDGHKGVFSVELTAVSSVHPQ
DPYLDKFFTLVHVLEEGAFPFRLKDTVLSEGNVEQELRASLAALRLASPEPLVAFSHHVL
DKLVRLVIRPPIISGQIVNLGRGAFEAMAHVVSLVHRSLEAAQDARGHCPQLAAYVHYAF
RLPGTEPSLPDGAPPVTVQAATLARGSGRPASLYLARSKSISSSNPDLAVAPGSVDDEVS
RILASKLLHEELALQWVVSSSAVREAILQHAWFFFQLMVKSMALHLLLGQRLDTPRKLRF
PGRFLDDITALVGSVGLEVITRVHKDVELAEHLNASLAFFLSDLLSLVDRGFVFSLVRAH
YKQVATRLQSSPNPAALLTLRMEFTRILCSHEHYVTLNLPCCPLSPPASPSPSVSSTTSQ
SSTFSSQAPDPKVTSMFELSGPFRQQHFLAGLLLTELALALEPEAEGAFLLHKKAISAVH
SLLCGHDTDPRYAEATVKARVAELYLPLLSIARDTLPRLHDFAEGPGQRSRLASMLDSDT
EGEGDIAGTINPSVAMAIAGGPLAPGSRASISQGPPTASRAGCALSAESSRTLLACVLWV
LKNTEPALLQRWATDLTLPQLGRLLDLLYLCLAAFEYKGKKAFERINSLTFKKSLDMKAR
LEEAILGTIGARQEMVRRSRERSPFGNPENVRWRKSVTHWKQTSDRVDKTKDEMEHEALV
EGNLATEASLVVLDTLEIIVQTVMLSEARESVLGAVLKVVLYSLGSAQSALFLQHGLATQ
RALVSKFPELLFEEDTELCADLCLRLLRHCGSRISTIRTHASASLYLLMRQNFEIGHNFA
RVKMQVTMSLSSLVGTTQNFSEEHLRRSLKTILTYAEEDMGLRDSTFAEQVQDLMFNLHM
ILTDTVKMKEHQEDPEMLIDLMYRIARGYQGSPDLRLTWLQNMAGKHAELGNHAEAAQCM
VHAAALVAEYLALLEDHRHLPVGCVSFQNISSNVLEESAISDDILSPDEEGFCSGKHFTE
LGLVGLLEQAAGYFTMGGLYEAVNEVYKNLIPILEAHRDYKKLAAVHGKLQEAFTKIMHQ
SSGWERVFGTYFRVGFYGAHFGDLDEQEFVYKEPSITKLAEISHRLEEFYTERFGDDVVE
IIKDSNPVDKSKLDSQKAYIQITYVEPYFDTYELKDRVTYFDRNYGLRTFLFCTPFTPDG
RAHGELPEQHKRKTLLSTDHAFPYIKTRIRVCHREETVLTPVEVAIEDMQKKTRELAFAT
EQDPPDAKMLQMVLQGSVGPTVNQGPLEVAQVFLAEIPEDPKLFRHHNKLRLCFKDFCKK
CEDALRKNKALIGPDQKEYHRELERNYCRLREALQPLLTQRLPQLMAPTPPGLRNSLNRA
SFRKADLLI

  • Gold
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  • Bronze
  • IntAct