Field Data
UniProt Accession: Q96N67
Gene Name: DOCK7
Gene Synonim: KIAA1771
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 7
Keywords: Acetylation;Alternative splicing;Cell projection;Coiled coil;Complete proteome;Developmental protein;Differentiation;Epilepsy;Guanine-nucleotide releasing factor;Methylation;Neurogenesis;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 85440
Ensembl Gene ID: ENSG00000116641
Ensembl Protein ID: ENSP00000489124
Our Specificity
Literature Specificity Rac1
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005925focal adhesion
GO:0005622intracellular
GO:0030426growth cone
GO:0030424axon
GO:0045178basal part of cell
GO:0043005neuron projection
GO:0042995cell projection

Molecular Function


GO ID Description
GO:0048365Rac GTPase binding
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process


GO ID Description
GO:0050767regulation of neurogenesis
GO:0033138positive regulation of peptidyl-serine phosphorylation
GO:0007399nervous system development
GO:0030154cell differentiation
GO:0090630activation of GTPase activity
GO:0045200establishment of neuroblast polarity
GO:0022027interkinetic nuclear migration
GO:0000226microtubule cytoskeleton organization
GO:0007409axonogenesis
GO:0031175neuron projection development
GO:1904754positive regulation of vascular associated smooth muscle cell migration
GO:0007264small GTPase mediated signal transduction
GO:0007275multicellular organism development

Reactome


Reactome ID Description
R-HSA-983231Factors involved in megakaryocyte development and platelet production
R-HSA-8875555MET activates RAP1 and RAC1

KEGG



Field Data
Localization in this study: cytosolic
Localization in the literature: plasma membrane

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK7
atgattttcaaagaagcagatgccaccaagaataaagaaaaactggagaaactgaagagt
caagcagatcagttttgccaaagacttgggaaatatcgcatgccttttgcttggactgca
atccatttaatgaatattgttagcagtgctgggagtttggaaagagattctacagaagta
gaaatcagtactggagaacgaaaagggtcttggtcagagaggaggaattctagtattgtt
ggcagacgatcacttgaaaggacaacaagtggagatgatgcttgtaacttgacgagcttt
cgaccagctactctcacagtgacaaatttttttaagcaggaaggagaccgcttaagtgat
gaagatctctacaaattccttgctgatatgagaaggccatcttctgtcttacggcgacta
agacctattacagctcagctcaagatagacatttctcccgcacctgaaaatccccattat
tgcctaactccggagctgcttcaagtgaagctttaccctgacagtagagttagacctacc
agagaaatcttagagtttcccgcaagggatgtttatgttccaaacactacttacagaaat
cttctctacatataccctcagagtcttaattttgccaatcgtcaaggttctgctagaaat
ataacagtgaaagtccagtttatgtatggagaggatccaagcaatgccatgccggtaatc
tttggtaaatctagctgttcagaattttcaaaggaagcctatacagccgtagtatatcat
aacaggtctcctgattttcatgaagaaatcaaggttaagcttcctgctactttaactgac
catcatcacttgctttttactttttatcatgttagttgtcaacaaaaacaaaatactcct
cttgaaacaccagttggatatacatggataccaatgcttcagaatggacggttgaagact
ggccagttttgcttgccagtctcattggaaaaaccaccacaggcttattctgtactgtct
cctgaggttcctctacctggcatgaaatgggtagataatcacaaaggtgtttttaatgtt
gaagttgttgctgtttcgtctatccatacacaagatccttatcttgacaaattttttgct
ctggtcaatgctctggatgaacacctgttcccagtccgaattggggacatgcgaatcatg
gaaaataacttagaaaatgaattgaagagcagtatttcagcactgaattcatcccagctg
gaaccagtggtccgatttcttcatcttctgctagataaactgatacttttagttattaga
cctcctgtcattgctggccaaatagttaacctaggtcaagcatcttttgaagccatggca
tcaattataaatcgacttcacaaaaacttggaaggaaatcatgaccagcatggcagaaac
agccttcttgcatcatatattcattatgttttccgcctaccaaatacttaccctaattca
tcatcaccaggtcctgggggtttgggaggatcagtgcattatgccacaatggctagatct
gcggtgagacctgcaagccttaatttaaatcgttctcgaagccttagtaatagcaatcca
gatatatctgggactcccacgtcaccagatgatgaagttcgatcaatcatcgggagtaag
gctatggatcgaagttgtaatcgtatgtcttcgcacacagagacgtcaagtttcttacaa
acattaacgggacgcttaccaactaaaaagctttttcacgaggagctggctttgcagtgg
gttgtttgcagtggcagcgttcgggaatcagctttgcaacaagcctggttcttttttgaa
ttaatggtaaagagcatggtgcaccatttatactttaatgataaacttgaggctccaagg
aaaagtcgttttccagaacgtttcatggatgacattgcagctcttgtcagcacgattgct
agtgatatagtttcacgatttcagaaggacacagaaatggttgagagactcaatacaagc
cttgcattctttctcaatgatctgttgtctgttatggacagaggatttgtttttagcctt
ataaagtcctgctataaacaggtgtcttcaaagctttactcattaccgaatcccagtgtt
ctggtgtccttgaggctggattttctacgaatcatctgcagtcatgagcactatgttaca
ttaaacttaccctgcagcttacttactccacctgcatctccatcaccttctgtttcttct
gcaacatctcagagttctggattttctacgaatgtacaagaccaaaagattgcaaatatg
tttgaattatccgtgcctttccgccaacagcattatttggcaggacttgtgttaacagag
ctggctgtcattttagaccctgatgctgaaggactgtttggattgcataagaaagtcatc
aatatggtacacaatttactctccagtcacgactcagacccgcggtactctgaccctcag
ataaaggctcgagtggccatgttgtatctacctctgattggtattatcatggaaactgta
cctcagctgtatgattttacagaaactcacaatcaacgaggaagaccaatttgtatagcc
actgatgattatgaaagtgagagcggaagtatgataagccagaccgttgccatggcaatc
gcagggacatcggtccctcaactaacaaggcctggcagtttcctcctcacgtcaacgagt
ggcaggcaacacactaccttttcagcagaatcaagtcgaagccttttgatctgtctactt
tgggttctcaaaaatgcagatgaaacagttctacagaagtggtttacagatctctcagtc
ttgcagctaaaccggctattagatctgctttatctctgtgtgtcttgctttgagtataaa
gggaaaaaagtgtttgaacgaatgaatagcttgacctttaagaaatcaaaagacatgaga
gcaaagcttgaagaagctattcttgggagcataggtgccaggcaagaaatggtacggcga
agccgaggacagctcggtacgtacacaatagcttctcctcctgagagaagcccatctgga
agtgcctttggaagtcaagaaaatttgaggtggaggaaagatatgactcactggcgtcaa
aacacagagaagcttgacaaatcaagagcagagattgaacacgaagcactgattgatgga
aacctggctacagaagcaaacctaatcattttagatacattagagattgttgttcagacc
gtttctgtaacggaatccaaagagagcattcttggtggagtgctaaaagtgctactacac
agcatggcctgtaaccaaagtgcagtttatctacaacactgttttgctacacagagagcc
ttggtttcaaagtttcctgaactcttatttgaagaagagacagagcagtgtgctgattta
tgcctcaggcttctccgacactgtagcagtagcatcggtacaatacggtcacacgccagt
gcctccctttacctactaatgaggcaaaactttgagattgggaataactttgccagggtt
aaaatgcaggtaacaatgtcactatcctccttggtgggcacatctcagaattttaatgaa
gaattcttaagacgttctctaaagactatattgacatatgctgaagaagatctggaattg
agggaaacaacatttcctgatcaggtccaggatctggttttcaatctccatatgattctt
tctgatactgtgaaaatgaaggaacaccaggaggatcctgaaatgttgattgatctaatg
tacagaattgccaagggttaccagacctctccagatctgcgattgacctggttgcagaac
atggcaggcaagcactcagaacgaagcaatcatgctgaagctgcacagtgtctagtccac
tcagcagcacttgttgctgaatatttgagcatgctggaggaccggaaatatcttcctgtg
ggatgtgtaacatttcagaatatttcatctaatgttttagaagaatctgcggtctcagat
gatgtggtatctccagatgaagaaggtatctgctctggaaaatactttactgagtcagga
cttgtgggattactggaacaagcagctgcttccttctctatggctggcatgtatgaagca
gttaatgaagtttacaaagtacttattcctattcatgaagctaatcgggatgcaaagaaa
ctatccacaattcatggtaaacttcaagaagcattcagcaaaattgttcatcagagtact
ggctgggagcggatgtttggcacctattttcgtgttggtttttatggaaccaagttcggg
gatttggatgaacaagaatttgtttacaaggagcctgcaataaccaaacttgcagagata
tctcacagattggagggattttacggagaaagatttggagaggatgtggttgaagtaatc
aaagactctaatcctgtagacaagtgtaaattagatcctaacaaggcatatattcagatt
acctatgtggagccatactttgacacatatgagatgaaggacagaatcacctatttcgac
aaaaattacaatcttcgtcgattcatgtactgtacaccctttactttagatggccgtgcc
catggggaacttcatgaacaattcaaaaggaagaccattctgactacgtctcatgccttt
ccttatattaaaacaagggtcaatgtcactcataaagaagagatcatcttaacaccaatt
gaagttgctattgaggacatgcagaaaaagacacaggagttggcatttgcaacacatcag
gatcccgcagaccccaaaatgcttcagatggtactccagggatctgtaggcaccacagtg
aatcaggggcctttggaagttgcccaggtttttctgtctgaaatacctagtgacccaaag
ctcttcagacatcataataaactgcgactctgctttaaagattttactaaaaggtgtgaa
gatgccttaagaaaaaataagagcttaattgggccggatcaaaaggagtatcaaagggaa
ctggagagaaactatcatcgccttaaagaggccctacagccactgatcaacagaaagatc
cctcagttatacaaggcagtattgcctgtcacctgccacagagattccttcagtcgaatg
agccttcgcaaaatggatctcttaatta

Protein Sequence

>DOCK7
MIFKEADATKNKEKLEKLKSQADQFCQRLGKYRMPFAWTAIHLMNIVSSAGSLERDSTEV
EISTGERKGSWSERRNSSIVGRRSLERTTSGDDACNLTSFRPATLTVTNFFKQEGDRLSD
EDLYKFLADMRRPSSVLRRLRPITAQLKIDISPAPENPHYCLTPELLQVKLYPDSRVRPT
REILEFPARDVYVPNTTYRNLLYIYPQSLNFANRQGSARNITVKVQFMYGEDPSNAMPVI
FGKSSCSEFSKEAYTAVVYHNRSPDFHEEIKVKLPATLTDHHHLLFTFYHVSCQQKQNTP
LETPVGYTWIPMLQNGRLKTGQFCLPVSLEKPPQAYSVLSPEVPLPGMKWVDNHKGVFNV
EVVAVSSIHTQDPYLDKFFALVNALDEHLFPVRIGDMRIMENNLENELKSSISALNSSQL
EPVVRFLHLLLDKLILLVIRPPVIAGQIVNLGQASFEAMASIINRLHKNLEGNHDQHGRN
SLLASYIHYVFRLPNTYPNSSSPGPGGLGGSVHYATMARSAVRPASLNLNRSRSLSNSNP
DISGTPTSPDDEVRSIIGSKAMDRSCNRMSSHTETSSFLQTLTGRLPTKKLFHEELALQW
VVCSGSVRESALQQAWFFFELMVKSMVHHLYFNDKLEAPRKSRFPERFMDDIAALVSTIA
SDIVSRFQKDTEMVERLNTSLAFFLNDLLSVMDRGFVFSLIKSCYKQVSSKLYSLPNPSV
LVSLRLDFLRIICSHEHYVTLNLPCSLLTPPASPSPSVSSATSQSSGFSTNVQDQKIANM
FELSVPFRQQHYLAGLVLTELAVILDPDAEGLFGLHKKVINMVHNLLSSHDSDPRYSDPQ
IKARVAMLYLPLIGIIMETVPQLYDFTETHNQRGRPICIATDDYESESGSMISQTVAMAI
AGTSVPQLTRPGSFLLTSTSGRQHTTFSAESSRSLLICLLWVLKNADETVLQKWFTDLSV
LQLNRLLDLLYLCVSCFEYKGKKVFERMNSLTFKKSKDMRAKLEEAILGSIGARQEMVRR
SRGQLGTYTIASPPERSPSGSAFGSQENLRWRKDMTHWRQNTEKLDKSRAEIEHEALIDG
NLATEANLIILDTLEIVVQTVSVTESKESILGGVLKVLLHSMACNQSAVYLQHCFATQRA
LVSKFPELLFEEETEQCADLCLRLLRHCSSSIGTIRSHASASLYLLMRQNFEIGNNFARV
KMQVTMSLSSLVGTSQNFNEEFLRRSLKTILTYAEEDLELRETTFPDQVQDLVFNLHMIL
SDTVKMKEHQEDPEMLIDLMYRIAKGYQTSPDLRLTWLQNMAGKHSERSNHAEAAQCLVH
SAALVAEYLSMLEDRKYLPVGCVTFQNISSNVLEESAVSDDVVSPDEEGICSGKYFTESG
LVGLLEQAAASFSMAGMYEAVNEVYKVLIPIHEANRDAKKLSTIHGKLQEAFSKIVHQST
GWERMFGTYFRVGFYGTKFGDLDEQEFVYKEPAITKLAEISHRLEGFYGERFGEDVVEVI
KDSNPVDKCKLDPNKAYIQITYVEPYFDTYEMKDRITYFDKNYNLRRFMYCTPFTLDGRA
HGELHEQFKRKTILTTSHAFPYIKTRVNVTHKEEIILTPIEVAIEDMQKKTQELAFATHQ
DPADPKMLQMVLQGSVGTTVNQGPLEVAQVFLSEIPSDPKLFRHHNKLRLCFKDFTKRCE
DALRKNKSLIGPDQKEYQRELERNYHRLKEALQPLINRKIPQLYKAVLPVTCHRDSFSRM
SLRKMDLLI

  • Gold
  • Silver
  • Bronze
  • IntAct