Field Data
UniProt Accession: Q96N96
Gene Name: SPATA13
Gene Synonim:
GAP/GEF: GEF
Description: Spermatogenesis-associated protein 13 (APC-stimulated guanine nucleotide exchange factor 2) (Asef2)
Keywords: Alternative splicing;Cell membrane;Cell projection;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 221178
Ensembl Gene ID: ENSG00000182957
Ensembl Protein ID: ENSP00000371527
Our Specificity Cdc42
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0030175filopodium
GO:0030027lamellipodium
GO:0005829cytosol
GO:0016020membrane
GO:0005654nucleoplasm
GO:0005886plasma membrane
GO:0042995cell projection
GO:0032587ruffle membrane

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0030676Rac guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0042802identical protein binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0016477cell migration
GO:0043547positive regulation of GTPase activity
GO:0030032lamellipodium assembly
GO:0030334regulation of cell migration
GO:0035023regulation of Rho protein signal transduction
GO:0046847filopodium assembly

Reactome

KEGG

Kegg ID Description
hsa04810Regulation of actin cytoskeleton
Field Data
Localization in this study: plasma_membrane
Localization in the literature: plasma membrane actin cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>SPATA13
atgacttctgccagccctgaagaccagaatgctccagtgggctgccccaaaggagcccgg
agaaggcgccccatttccgtgataggtggggtcagcttgtatgggaccaaccagacggag
gaactggacaatcttctgacccaaccggcttccaggccgcccatgcctgctcaccaggtg
ccaccctacaaggctgtgtcggcccggttccggcccttcacattctcccagagcaccccc
attgggttggaccgtgtgggacgccggcggcagatgagagcatccaacgtttcttcagat
ggaggtactgagccctctgccttagtggatgacaacggtagtgaggaggacttcagctat
gaagacctctgccaggccagccctcggtacctgcagcccggcggggagcagctggccatc
aatgagctgatcagtgatggcaacgtggtctgcgcagaagccctgtgggaccatgtgacc
atggatgaccaggaactgggcttcaaagccggggatgtcatccaggttctggaagcctcc
aacaaggactggtggtggggccgcagtgaagataaggaagcctggttccccgcgagcttc
gtcagattgcgagtgaatcaggaagagctgtcggaaaactccagcagcacccccagtgag
gagcaggacgaggaggccagccagagccgccacagacactgtgagaacaagcagcagatg
cggaccaacgtcatccgggagatcatggacaccgagcgggtgtacatcaaacacctcagg
gacatctgtgagggctatatccgacagtgccgcaagcacacaggaatgttcaccgttgcg
cagctagccactatttttggaaacattgaagatatttacaaattccaaagaaagtttctg
aaagaccttgagaaacagtacaacaaagaggaacctcacttaagtgaaataggatcttgc
tttcttcaaaatcaagagggctttgccatctattccgagtactgcaacaaccacccgggc
gcctgcctggagctcgccaacctcatgaagcagggcaagtacagacatttctttgaagcc
tgccgcctgctgcagcagatgattgacatcgccatcgacgggttcctgctcacaccagtg
cagaagatctgcaaatacccgctgcagctggccgagctgctcaagtataccacacaggaa
cacggtgattacagcaacataaaggcagcatatgaggccatgaagaatgtggcctgtctg
atcaacgagcgcaagcgcaagctggagagcatcgacaagatagctcgctggcaggtgtct
atcgtgggctgggagggactggatatcttagaccgaagctcagaattgattcattctggg
gagctgaccaaaatcactaagcaaggcaaaagccagcagcggacgttcttcctgtttgac
caccagctggtgtcctgcaagaaggacctgctgcgcagggacatgctgtactacaagggc
cggctggacatggatgagatggagcttgtggacctgggggatgggcgcgacaaggactgc
aacctcagcgtgaaaaatgccttcaagctcgtcagtaggaccacagacgaggtttatttg
ttttgtgccaaaaaacaagaagacaaggcgaggtggctgcaggcctgtgcagatgaaagg
aggcgggtgcaagaggacaaggagatgggaatggaaatttcagaaaaccagaagaaactt
gccatgttaaatgctcaaaaggcaggacatggaaagtcaaaaggctacaacaggtgccct
gtggccccaccgcaccagggcctgcaccccatccaccagcgccacatcactatgcccaca
agcgtcccccagcagcaggtctttggcctggcggaacccaagaggaagtcctcgctcttc
tggcacaccttcaacaggctcacccccttccggaaat

Protein Sequence

>SPATA13
MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQV
PPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSY
EDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEAS
NKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQM
RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL
KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEA
CRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACL
INERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFD
HQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYL
FCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCP
VAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK

  • Gold
  • Silver
  • Bronze
  • IntAct