Field Data
UniProt Accession: Q96P48
Gene Name: ARAP1
Gene Synonim:
GAP/GEF: GAP
Description: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)
Keywords: 3D-structure;Alternative splicing;Cell membrane;Complete proteome;Cytoplasm;GTPase activation;Golgi apparatus;Membrane;Metal-binding;Phosphoprotein;Polymorphism;Reference proteome;Repeat;Zinc;Zinc-finger
Entrez ID: 116985
Ensembl Gene ID: ENSG00000186635
Ensembl Protein ID: ENSP00000377233
Our Specificity Cdc42, Rac1
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005794Golgi apparatus
GO:0016020membrane
GO:0043231intracellular membrane-bounded organelle
GO:0031410cytoplasmic vesicle
GO:0005829cytosol
GO:0005802trans-Golgi network
GO:0005654nucleoplasm
GO:0005886plasma membrane
GO:0032580Golgi cisterna membrane

Molecular Function


GO ID Description
GO:0046872metal ion binding
GO:0031702type 1 angiotensin receptor binding
GO:0005096GTPase activator activity
GO:0005515protein binding
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding

Biological Process


GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0051270regulation of cellular component movement
GO:0043547positive regulation of GTPase activity
GO:0051497negative regulation of stress fiber assembly
GO:0051491positive regulation of filopodium assembly
GO:0030037actin filament reorganization involved in cell cycle
GO:0008360regulation of cell shape
GO:0045742positive regulation of epidermal growth factor receptor signaling pathway
GO:0007165signal transduction
GO:0001921positive regulation of receptor recycling

Reactome


Reactome ID Description
R-HSA-194840Rho GTPase cycle
R-HSA-8849469PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

KEGG


Kegg ID Description
hsa04144Endocytosis

Field Data
Localization in this study: cytosolic
Localization in the literature: Golgi vesicles actin

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARAP1
atgaccaagaaggaggagcccccaccgagccgagtcccacgggccgtgcgcgtggccagt
ctgctgagcgagggagaggaactgtctggggacgaccaaggggatgaggaagaggatgac
cacgcctatgagggcgtccccaatggcggatggcataccagcagcctgagcttgtccttg
cccagcacaatagctgcgccacaccccatggacgggccgcctgggggctccacccccgtc
acaccagtcatcaaggctggctggctggacaagaacccaccgcagggatcttacatctat
cagaaacgatgggtgagactggatactgatcacctgcgatactttgacagtaacaaggac
gcttactctaagcgctttatctctgtggcctgcatctcccacgtggctgccatcggggac
cagaagtttgaagtgatcacaaacaaccgaacctttgccttccgggcagagagtgatgtg
gagcggaaggagtggatgcaggccctgcagcaggccatggctgagcagcgtgcccgggcc
cggctctctagcgcttatctgctgggagttccaggctcagagcagcctgaccgcgctggc
agcctggagcttcgtggcttcaagaataagctgtacgtggccgtggtcggggacaaagtg
cagctctacaagaatctagaggagtaccacctgggcattggcatcaccttcatcgacatg
agcgtgggcaacgtgaaggaagtggaccggcgcagcttcgacctcaccacgccctaccgc
atcttcagcttctctgctgactcagagctagagaaggagcagtggttggaggccatgcag
ggagccatcgctgaggccctgtctacctcggaggtggccgagcgcatctgggctgcagcc
cccaacaggttctgtgctgactgcggggctcctcagcctgactgggcctccatcaacctc
tgtgttgttatctgcaagcgctgtgcaggggagcaccgtggcctgggcgctggcgtctcc
aaggtgcggagcctgaagatggacaggaaggtgtggacagaaacacttatcgagctcttc
ttacagctggggaatggcgctgggaaccgcttctgggcagccaacgtgccccccagtgag
gccctgcagcccagcagcagccccagcacccggcggtgccacctggaggccaagtaccgt
gagggcaagtaccgccgctaccacccgctctttggcaaccaggaggagctggacaaggcc
ctgtgtgctgcagtcaccaccacagacctggctgagacccaggcgctcctgggctgtggg
gctgggatcaactgcttctcgggggaccctgaggcccccacgcccctggctcttgcagag
caggcggggcagacgctgcagatggaattccttcggaacaaccggaccacagaggtgcct
cggctggactcgatgaagcccctggaaaagcactactcagttgtcctgccgaccgtgagc
cacagtggcttcctctacaagactgcctctgccggcaagctgctacaggaccgccgggcc
cgggaagagttcagccggcgctggtgtgtccttggtgacggggtcctgagctactttgag
aatgagcgggcagtgacccccaatggagagattcgggccagcgagattgtgtgcctggca
gtgccccctcctgacacccatggctttgagcacacctttgaggtgtacacggagggagaa
cggctgtacctgtttgggctggagagtgcggagcaggctcatgagtgggtcaagtgtatt
gctaaggcattcgtgcctcccctagccgaggatctgctggcccgggattttgagcggctg
ggacgcctaccctacaaagctggcctgagcctacagcgggcccaggagggctggttctct
ctcagtggctcggagctccgtgctgtcttcccggaggggccctgcgaagagccgctgcaa
ctacggaaactgcaggagctttccatccagggggacagtgagaaccaggtgctggtgctg
gtggagcgaaggaggacactgtacatacagggcgagcggcggctggacttcatgggttgg
ctgggggccatccagaaagcagccgccagcatgggggacacgctgtcggagcagcagctt
ggggactcggatatcccggtgatcgtgtaccgctgtgtggactacatcacgcagtgcggc
ctgacctccgagggcatctaccgcaagtgtgggcagacatcgaagacacagcggctgctg
gagagcctgcggcaggatgcgcgctctgtgcacctcaaggagggcgagcagcacgtggat
gatgtttcctcggcgctcaagcgcttcctgcgcgacctgcctgatgggctcttcactcgc
gcccagcgcctaacctggctggaggcctcagagattgaggacgaggaggagaaggtctcc
aggtaccgagagctgctggtgcggctgccccctgtcaaccgggccacagtgaaggccctt
atcagccacctgtactgtgttcagtgcttctcagacacgaaccagatgaacgtgcacaac
ctggcaattgtgtttgggcccacgctcttccagacagatgggcaggactacaaggctggc
cgtgtggtggaagacctcattaaccactatgtggtggtgtttagtgtggatgaggaagag
ctcaggaagcagcgggaggagatcactgccattgtgaagatgcgcgtggctggcactgcc
agtgggacccagcatgccggtgacttcatctgcacagtgtatctggaagagaagaaggca
gagactgagcagcatatcaaggtcccagcatccatgactgctgaggagctcaccctggag
atcctggatcgccggaacgtgggcatcagggagaaggactattggacctgctttgaggtc
aacgagagggaggaggcagagcgccccctgcactttgcggagaaggtgctgcccatcctg
cacgggctgggcacggacagccacctggtggtgaagaagcaccaggccatggaggccatg
ctgctgtacctggccagccgtgtcggtgacaccaagcatggcatgatgaagttccgtgag
gaccgcagcctcctgggcctgggcctgccctcaggtggcttccacgatcgctacttcatc
ctcaacagcagctgcttgcggctctacaaggaggtccggagccagaggccgtggagcggg
gcccctgagaccagtcaccggcctgagaaggagtggcctattaagagtctcaaagtctac
ctgggagtgaagaagaaactcaggccacccacctgctggggcttcacagtggtgcatgag
acagagaaacatgagaagcagcagtggtacctctgctgtgacacacagatggagctccgg
gagtggttcgctacctttctgtttgtgcagcatgacggcctggtgtggccctcagagccc
tcacgcgtgtcccgggcagtgcctgaggtccggctgggtagtgtgtcactgatccccctt
cgaggtagtgaaaatgaaatgcgccggagtgtggctgccttcaccgcggaccctctgtct
cttctgcgcaacgtcggaagctt

Protein Sequence

>ARAP1
MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELF
LQLGNGAGNRFWAANVPPSEALQPSSSPSTRRCHLEAKYREGKYRRYHPLFGNQEELDKA
LCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVP
RLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFE
NERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCI
AKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQ
LRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQL
GDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD
DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL
ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEE
LRKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLE
ILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAM
LLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSG
APETSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELR
EWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLS
LLRNVGS

  • Gold
  • Silver
  • Bronze
  • IntAct