Field Data
UniProt Accession: Q96PX9
Gene Name: PLEKHG4B
Gene Synonim: KIAA1909
GAP/GEF: GEF
Description: Pleckstrin homology domain-containing family G member 4B (PH domain-containing family G member 4B)
Keywords: Complete proteome;Polymorphism;Reference proteome
Entrez ID: 153478
Ensembl Gene ID: ENSG00000153404
Ensembl Protein ID: ENSP00000283426
Our Specificity Cdc42
Literature Specificity None
Domain Composition:

Cellular Component

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

KEGG

Field Data
Localization in this study: actin
Localization in the literature:

Confocal Images

Card image cap

Cytochalasin D Screen Positive

Card image cap
Card image cap
organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>PLEKHG4B
atggaagccttgcggaaccccatgcccctgggcagctctgaggaggccctcggggacctg
gcctgcagctccctgactggagccagcagggacctggggactggggcagtagccagtggg
acccaggaggaaacctctggcccccggggagacccccaacagaccccaagtctagagaag
gagaggcacacacccagccggacaggtccaggagctgcagggcggactcttcccaggaga
tctcggtcctgggaaagggcacccagaagctccagaggggcccaggctgcagcctgccac
acctcccaccactcagcaggctccaggcctgggggccacctaggaggacaagctgtgggg
accccaaactgtgtcccagtagagggtcccggctgcaccaaagaggaagacgttcttgca
tcctcagcctgtgtcagcacagacggcggcagcctccattgccacaaccccagcgggcct
tccgatgtgcctgcccggcagccacaccccgagcaagaagggtggccacccggcacagga
gacttccccagccaggtgcccaagcaggtgctggacgtcagtcaggagctgctgcagtcc
ggggtcgtcaccctcccagggacccgagaccgtcatggcagagcagtggtgcaggtccgc
accaggagcctgctctggaccagggaacactcgtcctgtgctgagctgacccgcctgctg
ctgtacttccatagcatccccaggaaagaggtccgggacctggggctggttgtcctggtg
gatgcacgcaggagtccagctgcccctgccgtctcccaggccctctcaggattgcagaac
aacacatctcctataattcatagtatcttgctgttggtagataaagaatctgcatttagg
cctgacaaggatgcaataattcagtgtgaggtcgtgagctccctgaaggccgtgcacaaa
tttgttgacagctgccagctgaccgcagacctcgacggctcctttccctacagccatggt
gactggatctgcttccgtcagaggctggaacacttcgctgcaaactgtgaagaagccatc
attttcctacagaattcattctgctccctgaacacccacagaaccccaagaacagcccag
gaagtcgccgagttaattgaccagcatgagacgatgatgaagcttgtcctggaagaccca
ctgcttgtgtctctcaggctggaggggggcaccgtcctggcgcggctgaggagagaagag
cttggcacagaagacagccgggacaccctggaggccgccacaagcctgtacgaccgagtg
gatgaggaggtgcacaggctggtcctcacctcgaacaatcgtctccagcagctggagcac
ctccgggagctggcgtcactcctggaagggaatgaccagcaatcctgccagaaaggacta
cagctggcgaaggagaacccgcaacgtacagaggaaatggtccaggatttcagaaggggc
ctgagcgccgtggtcagccaggctgagtgcagggagggagagctggccaggtggacccgc
tcgtccgagttgtgcgagacggtgagcagctggatggggcccctggacccggaggcttgt
ccctcctcacccgtggctgagtgtttgaggagctgtcaccaggaggctacctcggtggct
gcagaggccttccccggggcaggtgtggcagtgctgaagcctcatgccctggggaaaccg
tgggcatcacagcaagacctgtggctgcagtacccccagacccggctccgtctggaagag
gccctttctgaggctgccccagaccccagcttaccgccccttgcccagagccccccaaag
catgagcgtgcccaggaggccatgaggaggcaccagaagccaccctcattccccagcacg
gacagtgggggtggtgcctgggaacctgcccaaccactgtccggcctccctggacgagcg
cttctgtgtggacaggacggggagcccctgggcccagggctgtgtgctctgtgggaccca
ctgtccctcctcaggggccttccaggggcaggggccaccacggcccacctggaggacagc
tctgcctgttcctctgagcccacccagaccctggccagccgccccaggaaacatccccag
aagaaaatgataaagaaaacgcaaagtttcgagatacctcagcccgacagtggccccagg
gactcctgccagccagaccatactagtgtcttcagcaagggcctggaggtaaccagcact
gtagccacagagaagaagctcccgctgtggcagcatgccaggagccccccggtcactcag
agccggagtctgtcctccccctcggggctccaccctgctgaggaggatgggaggcagcag
gtgggcagcagccgactgaggcacatcatggccgagatgatcgccacagagagggagtac
attcggtgcttaggatacgtcattgacaactattttccagaaatggaaagaatggacttg
ccccagggccttcgagggaagcaccacgttattttcggcaacttggagaagctccacgac
ttccaccagcagcacttcctccgggagctggagcgctgccagcactgccccttggccgtg
ggccgcagtttcctgagacacgaagagcagtttgggatgtacgtgatctacagcaaaaac
aagccgcagtcggatgccctgctcagcagccatggcaacgccttcttcaaggacaagcag
cgggagctaggtgacaaaatggacctggcctcctacctgctgcggcccgtgcagcgtgtg
gccaagtacgcgctgctactccaggacctgctcaaggaggccagctgtggcctggcccag
gggcaggagctgggcgagctccgagccgccgaggtcgtggtctgcttccagctgcgtcac
ggcaatgacctgctggccatggacgccatccgcggctgtgacgtgaatttgaaggaacag
gggcagctgagatgccgggatgagtttatcgtttgctgcgggaggaagaagtatctgagg
catgtgttcctctttgaagacctcatcctgtttagcaagacccagaaggtggagggcagc
cacgacgtctacctgtacaagcagtccttcaagacggccgagatcgggatgacagagaac
gtcggggacagtggcttgaggtttgagatttggtttcgcaggcggcagaaatctcaggac
acctacattctccaagcaagctcggcagaggtcaagagtgcatggaccgatgtcataggg
aggatcctgtggcggcaggcactaaagagcagagaactcagaatccaagaaatggcatcc
atggggataggcaaccagccattcatggatgtcaagcccagagaccggacccctgactgt
gcagtgataagcgacggggctcccaaatgtgcagtgatgagcgaccgggtccccgacagc
atcgtcaagggcacagagtcacaaatgagagggtccacagcggtgtcctcctctgaccac
gccgcccccttcaagcgaccacactccaccatctcagacagcagcacctcctcttctagc
agccagtcctcctccatcctggggtcgctgggcctgcttgtgtcctccagcccagcccac
ccgggcctatggagccctgcccacagcccctggtcatctgatatcagagcctgcgtcgag
gaagatgagccagagccagaactagagacgggcacccaggctgcagtgtgtgagggggct
cctgctgtgctgctgagccgcacacgccaggcct

Protein Sequence

>PLEKHG4B
MEALRNPMPLGSSEEALGDLACSSLTGASRDLGTGAVASGTQEETSGPRGDPQQTPSLEK
ERHTPSRTGPGAAGRTLPRRSRSWERAPRSSRGAQAAACHTSHHSAGSRPGGHLGGQAVG
TPNCVPVEGPGCTKEEDVLASSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTG
DFPSQVPKQVLDVSQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLL
LYFHSIPRKEVRDLGLVVLVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFR
PDKDAIIQCEVVSSLKAVHKFVDSCQLTADLDGSFPYSHGDWICFRQRLEHFAANCEEAI
IFLQNSFCSLNTHRTPRTAQEVAELIDQHETMMKLVLEDPLLVSLRLEGGTVLARLRREE
LGTEDSRDTLEAATSLYDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGL
QLAKENPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDPEAC
PSSPVAECLRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQYPQTRLRLEE
ALSEAAPDPSLPPLAQSPPKHERAQEAMRRHQKPPSFPSTDSGGGAWEPAQPLSGLPGRA
LLCGQDGEPLGPGLCALWDPLSLLRGLPGAGATTAHLEDSSACSSEPTQTLASRPRKHPQ
KKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPLWQHARSPPVTQ
SRSLSSPSGLHPAEEDGRQQVGSSRLRHIMAEMIATEREYIRCLGYVIDNYFPEMERMDL
PQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGRSFLRHEEQFGMYVIYSKN
KPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLLQDLLKEASCGLAQ
GQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEFIVCCGRKKYLR
HVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEIWFRRRQKSQD
TYILQASSAEVKSAWTDVIGRILWRQALKSRELRIQEMASMGIGNQPFMDVKPRDRTPDC
AVISDGAPKCAVMSDRVPDSIVKGTESQMRGSTAVSSSDHAAPFKRPHSTISDSSTSSSS
SQSSSILGSLGLLVSSSPAHPGLWSPAHSPWSSDIRACVEEDEPEPELETGTQAAVCEGA
PAVLLSRTRQA

  • Gold
  • Silver
  • Bronze
  • IntAct