---

Cellular Component

---

GO ID	Description
GO:0005737	cytoplasm
GO:0043234	protein complex
GO:0001726	ruffle
GO:0031982	vesicle
GO:0043197	dendritic spine
GO:0030027	lamellipodium
GO:0005813	centrosome
GO:0005829	cytosol
GO:0016020	membrane
GO:0030426	growth cone
GO:0030425	dendrite
GO:0030424	axon
GO:0014069	postsynaptic density
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0005769	early endosome
GO:0043231	intracellular membrane-bounded organelle

---

Molecular Function

---

GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0030676	Rac guanyl-nucleotide exchange factor activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0017137	Rab GTPase binding
GO:0017112	Rab guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0043539	protein serine/threonine kinase activator activity
GO:0042803	protein homodimerization activity

---

Biological Process

---

GO ID	Description
GO:0008104	protein localization
GO:0061024	membrane organization
GO:0035022	positive regulation of Rac protein signal transduction
GO:0035023	regulation of Rho protein signal transduction
GO:0071902	positive regulation of protein serine/threonine kinase activity
GO:0008219	cell death
GO:0043087	regulation of GTPase activity
GO:0035249	synaptic transmission, glutamatergic
GO:0001662	behavioral fear response
GO:0001701	in utero embryonic development
GO:0043547	positive regulation of GTPase activity
GO:0016601	Rac protein signal transduction
GO:0001881	receptor recycling
GO:0007626	locomotory behavior
GO:0007528	neuromuscular junction development
GO:0007409	axonogenesis
GO:0051036	regulation of endosome size
GO:0006979	response to oxidative stress
GO:0007032	endosome organization
GO:0016197	endosomal transport
GO:0016050	vesicle organization
GO:0048812	neuron projection morphogenesis
GO:0045860	positive regulation of protein kinase activity

---

Reactome

---

Reactome ID	Description
R-HSA-8876198	RAB GEFs exchange GTP for GDP on RABs

---

KEGG

---

Kegg ID	Description
hsa05014	Amyotrophic lateral sclerosis (ALS)

---

Field	Data
Localization in this study:	vesicles
Localization in the literature:	vesicles centrosomes