Field Data
UniProt Accession: Q9BZ29
Gene Name: DOCK9
Gene Synonim: KIAA1058, ZIZ1
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 9 (Cdc42 guanine nucleotide exchange factor zizimin-1) (Zizimin-1)
Keywords: 3D-structure;Alternative splicing;Coiled coil;Complete proteome;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome;Repeat
Entrez ID: 23348
Ensembl Gene ID: ENSG00000088387
Ensembl Protein ID: ENSP00000487551
Our Specificity
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol
GO:0016020membrane
GO:0012505endomembrane system

Molecular Function

GO ID Description
GO:0005085guanyl-nucleotide exchange factor activity
GO:0045296cadherin binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0007596blood coagulation
GO:0007264small GTPase mediated signal transduction
GO:0008150biological_process
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-983231Factors involved in megakaryocyte development and platelet production

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK9
atgcaggctgataaatgcaggacaagtagtagaagtgtcaaaaaggaactggtgattgag
tcccccctgcaatacaaggatgcagctcagggcgaagtggaagcagagagcccgggccct
gtgccggcaaagccaaagctaattgagccactcgactatgaaaatgtcatcgtccagaag
aagactcagatcctgaacgactgtttacgggagatgctgctcttcccttacgatgacttt
cagacggccatcctgagacgacagggtcgatacatatgctcaacagtgcctgcgaaggcg
gaagaggaagcacagagcttgtttgttacagagtgcatcaaaacctataactctgactgg
catcttgtgaactataaatatgaagattactcaggagagtttcgacagcttccgaacaaa
gtggtcaagttggataaacttccagttcatgtctatgaagttgacgaggaggtcgacaaa
gatgaggatgctgcctcccttggttcccagaagggtgggatcaccaagcatggctggctg
tacaaaggcaacatgaacagtgccatcagcgtgaccatgaggtcatttaagagacgattt
ttccacctgattcaacttggcgatggatcctataatttgaatttttataaagatgaaaag
atctccaaagaaccaaaaggatcaatatttctggattcctgtatgggtgtcgttcagaac
aacaaagtcaggcgttttgcttttgagctcaagatgcaggacaaaagtagttatctcttg
gcagcagacagtgaagtggaaatggaagaatggatcacaattctaaataagatcctccag
ctcaactttgaagctgcaatgcaagaaaagcgaaatggcgactctcacgaagatgatgaa
caaagcaaattggaaggttctggttccggtttagatagctacctgccggaacttgccaag
agtgcaagagaagcagaaatcaaactgaaaagtgaaagcagagtcaaacttttttatttg
gacccagatgcccagaagcttgacttctcatcagctgagccagaagtgaagtcatttgaa
gagaagtttggaaaaaggatccttgtcaagtgcaatgatttatctttcaatttgcaatgc
tgtgttgccgaaaatgaagaaggacccactacaaatgttgaacctttctttgttactcta
tccctgtttgacataaaatacaaccggaagatttctgccgatttccacgtagacctgaac
catttctcagtgaggcaaatgctcgccaccacgtccccggcgctgatgaatggcagtggg
cagagcccatctgtcctcaagggcatccttcatgaagccgccatgcagtatccgaagcag
ggaatattttcagtcacttgtcctcatccagatatatttcttgtggccagaattgaaaaa
gtccttcaggggagcatcacacattgcgctgagccatatatgaaaagttcagactcttct
aaggtggcccagaaggtgctgaagaatgccaagcaggcatgccaaagactaggacagtat
agaatgccatttgcttgggcagcaaggacattgtttaaggatgcatctggaaatcttgac
aaaaatgccagattttctgccatctacaggcaagacagcaataagctatccaatgatgac
atgctcaagttacttgcagactttcggaaacctgagaagatggctaagctcccagtgatt
ttaggcaatctagacattacaattgataatgtttcctcagacttccctaattatgttaat
tcatcatacattcccacaaaacaatttgaaacctgcagtaaaactcccatcacgtttgaa
gtggaggaatttgtgccctgcataccaaaacacactcagccttacaccatctacaccaat
cacctttacgtttatcctaagtacttgaaatacgacagtcagaagtcttttgccaaggct
agaaatattgcgatttgcattgaattcaaagattcagatgaggaagactctcagcccctt
aagtgcatttatggcagacctggtgggccagttttcacaagaagcgcctttgctgcagtt
ttacaccatcaccaaaacccagaattttatgatgagattaaaatagagttgcccactcag
ctgcatgaaaagcaccacctgttgctcacattcttccatgtcagctgtgacaactcaagt
aaaggaagcacgaagaagagggatgtcgttgaaacccaagttggctactcctggcttccc
ctcctgaaagacggaagggtggtgacaagcgagcagcacatcccggtctcggcgaacctt
ccttcgggctatcttggctaccaggagcttgggatgggcaggcattatggtccggaaatt
aaatgggtagatggaggcaagccactgctgaaaatttccactcatctggtttctacagtg
tatactcaggatcagcatttacataattttttccagtactgtcagaaaaccgaatctgga
gcccaagccttaggaaacgaacttgtaaagtaccttaagagtctgcatgcgatggaaggc
cacgtgatgatcgccttcttgcccactatcctaaaccagctgttccgagtcctcaccaga
gccacacaggaagaagtcgcggttaacgtgactcgggtcattattcatgtggttgcccag
tgccatgaggaaggattggagagccacttgaggtcatatgttaagtacgcgtataaggct
gagccatatgttgcctctgaatacaagacagtgcatgaagaactgaccaaatccatgacc
acgattctcaagccttctgccgatttcctcaccagcaacaaactactgaagtactcatgg
tttttctttgatgtactgatcaaatctatggctcagcatttgatagagaactccaaagtt
aagttgctgcgaaaccagagatttcctgcatcctatcatcatgcagtggaaaccgttgta
aatatgctgatgccacacatcactcagaagtttcgagataatccagaggcatctaagaac
gcgaatcatagccttgctgtcttcatcaagagatgtttcaccttcatggacaggggcttt
gtcttcaagcagatcaacaactacattagctgttttgctcctggagacccaaagaccctc
tttgaatacaagtttgaatttctccgtgtagtgtgcaaccatgaacattatattccgttg
aacttaccaatgccatttggaaaaggcaggattcaaagataccaagacctccagcttgac
tactcattaacagatgagttctgcagaaaccacttcttggtgggactgttactgagggag
gtggggacagccctccaggagttccgggaggtccgtctgatcgccatcagtgtgctcaag
aacctgctgataaagcattcttttgatgacagatatgcttcaaggagccatcaggcaagg
atagccaccctctacctgcctctgtttggtctgctgattgaaaacgtccagcggatcaat
gtgagggatgtgtcacccttccctgtgaacgcgggcatgactgtgaaggatgaatccctg
gctctaccagctgtgaatccgctggtgacgccgcagaagggaagcaccctggacaacagc
ctgcacaaggacctgctgggcgccatctccggcattgcttctccatatacaacctcaact
ccaaacatcaacagtgtgagaaatgctgattcgagaggatctctcataagcacagattcg
ggtaacagccttccagaaaggaatagtgagaagagcaattccctggataagcaccaacaa
agtagcacattgggaaattccgtggttcgctgtgataaacttgaccagtctgagattaag
agcctactgatgtgtttcctctacatcttaaagagcatgtctgatgatgctttgtttaca
tattggaacaaggcttcaacatctgaacttatggatttttttacaatatctgaagtctgc
ctgcaccagttccagtacatggggaagcgatacatagccagaacaggaatgatgcatgcc
agattgcagcagctgggcagcctggataactctctcacttttaaccacagctatggccac
tcggacgcagatgttctgcaccagtcattacttgaagccaacattgctactgaggtttgc
ctgacagctctggacacgctttctctatttacattggcgtttaagaaccagctcctggcc
gaccatggacataatcctctcatgaaaaaagtttttgatgtctacctgtgttttcttcaa
aaacatcagtctgaaacggctttaaaaaatgtcttcactgccttaaggtccttaatttat
aagtttccctcaacattctatgaagggagagcggacatgtgtgcggctctgtgttacgag
attctcaagtgctgtaactccaagctgagctccatcaggacggaggcctcccagctgctc
tacttcctgatgaggaacaactttgattacactggaaagaagtcctttgtccggacacat
ttgcaagtcatcatatctgtcagccagctgatagcagacgttgttggcattgggggaacc
agattccagcagtccctgtccatcatcaacaactgtgccaacagtgaccggcttattaag
cacaccagcttctcctctgatgtgaaggacttaaccaaaaggatacgcacggtgctaatg
gccaccgcccagatgaaggagcatgagaacgacccagagatgctggtggacctccagtac
agcctggccaaatcctatgccagcacgcccgagctcaggaagacgtggctcgacagcatg
gccaggatccatgtcaaaaatggcgatctctcagaggcagcaatgtgctatgtccacgta
acagccctagtggcagaatatctcacacggaaagaagcagtccagtgggagccgcccctt
ctcccccacagccatagcgcctgcctgaggaggagccggggaggcgtgtttagacaagga
tgcaccgccttcagggtcattaccccaaacatcgacgaggaggcctccatgatggaagac
gtggggatgcaggatgtccatttcaacgaggatgtgctgatggagctccttgagcagtgc
gcagatggactctggaaagccgagcgctacgagctcatcgccgacatctacaaacttatc
atccccatttatgagaagcggagggattttgagaggctggcccatctgtatgacacgctg
caccgggcctacagcaaagtgaccgaggtcatgcactcgggccgcaggcttctggggacc
tacttccgggtagccttcttcgggcaggcagcgcaataccagtttacagacagtgaaaca
gatgtggagggattctttgaagatgaagatggaaaggagtatatttacaaggaacccaaa
ctcacaccgctgtcggaaatttctcagagactccttaaactgtactcggataaatttggt
tctgaaaatgtcaaaatgatacaggattctggcaaggtcaaccctaaggatctggattct
aagtatgcatacatccaggtgactcacgtcatccccttctttgacgaaaaagagttgcaa
gaaaggaaaacagagtttgagagatcccacaacatccgccgcttcatgtttgagatgcca
tttacgcagaccgggaagaggcagggcggggtggaagagcagtgcaaacggcgcaccatc
ctgacagccatacactgcttcccttatgtgaagaagcgcatccctgtcatgtaccagcac
cacactgacctgaaccccatcgaggtggccattgacgagatgagtaagaaggtggcggag
ctccggcagctgtgctcctcggccgaggtggacatgatcaaactgcagctcaaactccag
ggcagcgtgagtgttcaggtcaatgctggcccactagcatatgcgcgagctttcttagat
gatacaaacacaaagcgatatcctgacaataaagtgaagctgcttaaggaagttttcagg
caatttgtggaagcttgcggtcaagccttagcggtaaacgaacgtctgattaaagaagac
cagctcgagtatcaggaagaaatgaaagccaactacagggaaatggcgaaggagctttct
gaaatcatgcatgagcagctgggattaatta

Protein Sequence

>DOCK9
MQADKCRTSSRSVKKELVIESPLQYKDAAQGEVEAESPGPVPAKPKLIEPLDYENVIVQK
KTQILNDCLREMLLFPYDDFQTAILRRQGRYICSTVPAKAEEEAQSLFVTECIKTYNSDW
HLVNYKYEDYSGEFRQLPNKVVKLDKLPVHVYEVDEEVDKDEDAASLGSQKGGITKHGWL
YKGNMNSAISVTMRSFKRRFFHLIQLGDGSYNLNFYKDEKISKEPKGSIFLDSCMGVVQN
NKVRRFAFELKMQDKSSYLLAADSEVEMEEWITILNKILQLNFEAAMQEKRNGDSHEDDE
QSKLEGSGSGLDSYLPELAKSAREAEIKLKSESRVKLFYLDPDAQKLDFSSAEPEVKSFE
EKFGKRILVKCNDLSFNLQCCVAENEEGPTTNVEPFFVTLSLFDIKYNRKISADFHVDLN
HFSVRQMLATTSPALMNGSGQSPSVLKGILHEAAMQYPKQGIFSVTCPHPDIFLVARIEK
VLQGSITHCAEPYMKSSDSSKVAQKVLKNAKQACQRLGQYRMPFAWAARTLFKDASGNLD
KNARFSAIYRQDSNKLSNDDMLKLLADFRKPEKMAKLPVILGNLDITIDNVSSDFPNYVN
SSYIPTKQFETCSKTPITFEVEEFVPCIPKHTQPYTIYTNHLYVYPKYLKYDSQKSFAKA
RNIAICIEFKDSDEEDSQPLKCIYGRPGGPVFTRSAFAAVLHHHQNPEFYDEIKIELPTQ
LHEKHHLLLTFFHVSCDNSSKGSTKKRDVVETQVGYSWLPLLKDGRVVTSEQHIPVSANL
PSGYLGYQELGMGRHYGPEIKWVDGGKPLLKISTHLVSTVYTQDQHLHNFFQYCQKTESG
AQALGNELVKYLKSLHAMEGHVMIAFLPTILNQLFRVLTRATQEEVAVNVTRVIIHVVAQ
CHEEGLESHLRSYVKYAYKAEPYVASEYKTVHEELTKSMTTILKPSADFLTSNKLLKYSW
FFFDVLIKSMAQHLIENSKVKLLRNQRFPASYHHAVETVVNMLMPHITQKFRDNPEASKN
ANHSLAVFIKRCFTFMDRGFVFKQINNYISCFAPGDPKTLFEYKFEFLRVVCNHEHYIPL
NLPMPFGKGRIQRYQDLQLDYSLTDEFCRNHFLVGLLLREVGTALQEFREVRLIAISVLK
NLLIKHSFDDRYASRSHQARIATLYLPLFGLLIENVQRINVRDVSPFPVNAGMTVKDESL
ALPAVNPLVTPQKGSTLDNSLHKDLLGAISGIASPYTTSTPNINSVRNADSRGSLISTDS
GNSLPERNSEKSNSLDKHQQSSTLGNSVVRCDKLDQSEIKSLLMCFLYILKSMSDDALFT
YWNKASTSELMDFFTISEVCLHQFQYMGKRYIARTGMMHARLQQLGSLDNSLTFNHSYGH
SDADVLHQSLLEANIATEVCLTALDTLSLFTLAFKNQLLADHGHNPLMKKVFDVYLCFLQ
KHQSETALKNVFTALRSLIYKFPSTFYEGRADMCAALCYEILKCCNSKLSSIRTEASQLL
YFLMRNNFDYTGKKSFVRTHLQVIISVSQLIADVVGIGGTRFQQSLSIINNCANSDRLIK
HTSFSSDVKDLTKRIRTVLMATAQMKEHENDPEMLVDLQYSLAKSYASTPELRKTWLDSM
ARIHVKNGDLSEAAMCYVHVTALVAEYLTRKEAVQWEPPLLPHSHSACLRRSRGGVFRQG
CTAFRVITPNIDEEASMMEDVGMQDVHFNEDVLMELLEQCADGLWKAERYELIADIYKLI
IPIYEKRRDFERLAHLYDTLHRAYSKVTEVMHSGRRLLGTYFRVAFFGQAAQYQFTDSET
DVEGFFEDEDGKEYIYKEPKLTPLSEISQRLLKLYSDKFGSENVKMIQDSGKVNPKDLDS
KYAYIQVTHVIPFFDEKELQERKTEFERSHNIRRFMFEMPFTQTGKRQGGVEEQCKRRTI
LTAIHCFPYVKKRIPVMYQHHTDLNPIEVAIDEMSKKVAELRQLCSSAEVDMIKLQLKLQ
GSVSVQVNAGPLAYARAFLDDTNTKRYPDNKVKLLKEVFRQFVEACGQALAVNERLIKED
QLEYQEEMKANYREMAKELSEIMHEQLGLI

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