Field Data
UniProt Accession: Q9C0H5
Gene Name: ARHGAP39
Gene Synonim: KIAA1688
GAP/GEF: GAP
Description: Rho GTPase-activating protein 39
Keywords: Acetylation;Alternative splicing;Complete proteome;Nucleus;Phosphoprotein;Reference proteome;Repeat
Entrez ID: 80728
Ensembl Gene ID: ENSG00000147799
Ensembl Protein ID: ENSP00000366522
Our Specificity Cdc42, Rac1
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005856cytoskeleton
GO:0005634nucleus
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle
R-HSA-428543Inactivation of CDC42 and RAC1

KEGG

Field Data
Localization in this study: focal_adhesions, nucleus, plasma_membrane
Localization in the literature: plasma membrane

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP39
atgtcccagacgcaggactacgagtgcaggagccataatgtcgacctgccggagtcgagg
attccagggtcgaacactcggttggagtgggtggagatcatcgaaccgcgcacccgcgag
cgcatgtacgccaacctggtcaccggtgagtgcgtgtgggacccgccggccggcgtccgc
atcaagcgcaccagcgagaaccagtggtgggagctgttcgaccccaacacgtcccgcttc
tactactacaatgccagcacgcagcgcacggtgtggcaccggccgcagggctgcgacatc
atcccgctggccaagctgcagacgctgaagcagaacacggagtccccgcgcgcctcggcg
gagagcagccccgggcgcggcagcagcgtcagccgtgagggcagcaccagctcctccctg
gagcccgagcccgacactgagaaagcgcaggagttgccagcgagggccgggcggcccgcg
gcgtttgggacagtgaaggaggacagcggcagctcttcaccaccaggagtgttccttgag
aaggactatgagatttaccgggattacagtgcggacggccagcttcttcactacaggacc
tcctcgctgcggtggaactcgggcgccaaagagcgcatgctcatcaaggtcgctgatcgg
gagcccagcttcctcgccgcccagggcaatggctacgccccagacggcccacctggggtc
cgctcccgcagaccctccggcagccagcactcacccagcctgcagaccttcgccccggag
gctgacggcaccatcttcttcccagagaggaggccgtcacccttcctgaagagggccgag
ctcccagggagcagctccccgctgctggcccagccccgaaagccctccggggactcgcag
ccctcctccccgcgctatggctatgaacccccgctctacgaggagcccccagtggagtac
caggcccccatctacgatgagccccccatggacgtgcaattcgaggctggcgggggctac
caggccggctctccccagcggtcgccgggccgtaagccccggccgttcctccagcccaac
aagcagggccccccctcgccctgccagcagctggtgctcaccaagcagaagtgtcccgag
cgcttcctgagcctggagtacagtcccgccggcaaggagtacgtgcggcagctggtctac
gtggagcaggcgggctccagccccaagctgcgcgccggcccgcggcacaagtacgcgccc
aaccccggcggtggttcgtactccttgcagcccagcccctgcctgctgagggaccagcgc
ctgggcgtcaagtccggagactacagcaccatggagggacctgagctgcggcacagccag
ccgcccacgccgctgccacaggcccaggaggatgccatgtcctggtccagccagcaggac
accctgtcctccacaggctactccccgggcacgcgcaagcggaagagcagaaagccctct
ttgtgccaagccaccagcgccacccccactgagggccccggggacctgcttgtggagcag
cccctggccgaggaacagcccccgtgcgggaccagcctcgcccccgtgaagcgagcggaa
ggtgaggccgaaggggcgcggggcgcggccgagcccttcctggcgcaggctcggctggcc
tgggaggcgcagcaggcccacttccacatgaagcagaggagcagctgggactcccagcag
gacggctctggctacgagagcgacggcgccctgccactgcccatgcccgggccggtggtg
cgggccttcagcgaggacgaggcgctggcccagcaggagaacaggcactggaggaggggc
accttcgagaagctaggcttcccccagatcctgctggagaagagcgtctccgtgcagacc
aacctggcctcaccagagccctacctccacccctcacagtctgaggacctcgctgcctgt
gcccagttcgagagcagccggcagagccgcagcggcgttcccagctccagctgcgtcttc
cccactttcacgctgcgcaagccctcctcggagacggacatcgagaactgggcctccaag
cacttcaacaagcacacgcagggcctcttccggcggaaggtgtccatcgccaacatgctg
gcctggagcagcgagtccatcaagaagcccatgatcgtgacaagcgaccggcacgtgaag
aaggaggcctgcgagctcttcaagctgatccagatgtacatgggtgaccggcgggccaag
gccgacccactgcacgtggccctggaggtggccaccaagggctggagcgtgcagggcctg
cgggacgagctctacatccagctgtgccggcagaccaccgagaacttccgcctggagagc
ctggcccgcggctgggagctcatggccatctgcctggcctttttcccgcccacccccaag
ttccactcctacctggaaggctacatctaccggcacatggaccccgtcaatgacactaaa
gtgacacagcacataaaagagctcctggaaagaaacactaagaagaagtccaaattgaga
aagaaacccaagccttatgttgaagagccggatggggtggcgataagcacgtatgccaag
tactgttaccacaagctacagaaggcagccctgaccggggccaagaaggggctgaagaag
cccaacgtggaggagatccggcatgccaagaacgccgtgttcagcccgtccatgttcggc
agcgcactgcaggaggtcatgggcatgcagagagagcgctaccccgagcgccagctgccc
tgggtgcagacacggctctctgaggaggtgctggcgctcaacggtgaccagacagagggc
atcttcagggtccctggggacattgacgaggtgaatgccctgaagctgcaggtggaccag
tggaaggtgcccacaggcctggaagacccccacgtccctgcgtccctgctgaagctgtgg
taccgggagctggaggagcccctgatcccgcacgagttctacgagcagtgcatcgcgcac
tacgacagccccgaggcggcggtggccgtggtgcacgcgctgccccgcatcaaccgcatg
gtgctgtgctacctcatccgcttcctgcaggtcttcgtgcagccggccaacgtcgcggtc
accaagatggatgtcagcaacctggccatggtgatggcgcccaactgcttgcgctgccag
tccgacgacccgcgcgtcatcttcgagaacacccgcaaggagatgtccttcctgcgggtg
ctcatccagcacctggacaccagcttcatggagggtgtgctgttaatta

Protein Sequence

>ARHGAP39
MSQTQDYECRSHNVDLPESRIPGSNTRLEWVEIIEPRTRERMYANLVTGECVWDPPAGVR
IKRTSENQWWELFDPNTSRFYYYNASTQRTVWHRPQGCDIIPLAKLQTLKQNTESPRASA
ESSPGRGSSVSREGSTSSSLEPEPDTEKAQELPARAGRPAAFGTVKEDSGSSSPPGVFLE
KDYEIYRDYSADGQLLHYRTSSLRWNSGAKERMLIKVADREPSFLAAQGNGYAPDGPPGV
RSRRPSGSQHSPSLQTFAPEADGTIFFPERRPSPFLKRAELPGSSSPLLAQPRKPSGDSQ
PSSPRYGYEPPLYEEPPVEYQAPIYDEPPMDVQFEAGGGYQAGSPQRSPGRKPRPFLQPN
KQGPPSPCQQLVLTKQKCPERFLSLEYSPAGKEYVRQLVYVEQAGSSPKLRAGPRHKYAP
NPGGGSYSLQPSPCLLRDQRLGVKSGDYSTMEGPELRHSQPPTPLPQAQEDAMSWSSQQD
TLSSTGYSPGTRKRKSRKPSLCQATSATPTEGPGDLLVEQPLAEEQPPCGTSLAPVKRAE
GEAEGARGAAEPFLAQARLAWEAQQAHFHMKQRSSWDSQQDGSGYESDGALPLPMPGPVV
RAFSEDEALAQQENRHWRRGTFEKLGFPQILLEKSVSVQTNLASPEPYLHPSQSEDLAAC
AQFESSRQSRSGVPSSSCVFPTFTLRKPSSETDIENWASKHFNKHTQGLFRRKVSIANML
AWSSESIKKPMIVTSDRHVKKEACELFKLIQMYMGDRRAKADPLHVALEVATKGWSVQGL
RDELYIQLCRQTTENFRLESLARGWELMAICLAFFPPTPKFHSYLEGYIYRHMDPVNDTK
VTQHIKELLERNTKKKSKLRKKPKPYVEEPDGVAISTYAKYCYHKLQKAALTGAKKGLKK
PNVEEIRHAKNAVFSPSMFGSALQEVMGMQRERYPERQLPWVQTRLSEEVLALNGDQTEG
IFRVPGDIDEVNALKLQVDQWKVPTGLEDPHVPASLLKLWYRELEEPLIPHEFYEQCIAH
YDSPEAAVAVVHALPRINRMVLCYLIRFLQVFVQPANVAVTKMDVSNLAMVMAPNCLRCQ
SDDPRVIFENTRKEMSFLRVLIQHLDTSFMEGVLLI

  • Gold
  • Silver
  • Bronze
  • IntAct