Field Data
UniProt Accession: Q9H0H5
Gene Name: RACGAP1
Gene Synonim: KIAA1478, MGCRACGAP
GAP/GEF: GAP
Description: Rac GTPase-activating protein 1 (Male germ cell RacGap) (MgcRacGAP) (Protein CYK4 homolog) (CYK4) (HsCYK-4)
Keywords: 3D-structure;Acetylation;Cell cycle;Cell division;Cell membrane;Coiled coil;Complete proteome;Cytoplasm;Cytoplasmic vesicle;Cytoskeleton;Developmental protein;Differentiation;GTPase activation;Ion transport;Isopeptide bond;Lipid-binding;Membrane;Metal-binding;Microtubule;Nucleus;Phosphoprotein;Reference proteome;Spermatogenesis;Transport;Ubl conjugation;Zinc;Zinc-finger
Entrez ID: 29127
Ensembl Gene ID: ENSG00000161800
Ensembl Protein ID: ENSP00000449374
Our Specificity Rac1
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0005819spindle
GO:0051233spindle midzone
GO:0070062extracellular exosome
GO:0031410cytoplasmic vesicle
GO:0005634nucleus
GO:0016020membrane
GO:0030496midbody
GO:0032154cleavage furrow
GO:0097149centralspindlin complex
GO:0031234extrinsic component of cytoplasmic side of plasma membrane
GO:0005654nucleoplasm
GO:0072686mitotic spindle
GO:0001669acrosomal vesicle
GO:0005886plasma membrane
GO:0005874microtubule
GO:0005829cytosol

Molecular Function


GO ID Description
GO:0008017microtubule binding
GO:0005096GTPase activator activity
GO:0008289lipid binding
GO:0005547phosphatidylinositol-3,4,5-trisphosphate binding
GO:0019901protein kinase binding
GO:0048487beta-tubulin binding
GO:0005515protein binding
GO:0043014alpha-tubulin binding
GO:0043015gamma-tubulin binding
GO:0046872metal ion binding

Biological Process


GO ID Description
GO:0030154cell differentiation
GO:0007165signal transduction
GO:0008272sulfate transport
GO:0035556intracellular signal transduction
GO:0007275multicellular organism development
GO:0051301cell division
GO:0043547positive regulation of GTPase activity
GO:0000281mitotic cytokinesis
GO:0007049cell cycle
GO:0032467positive regulation of cytokinesis
GO:0051056regulation of small GTPase mediated signal transduction
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0006811ion transport
GO:0006810transport
GO:0007283spermatogenesis
GO:0051988regulation of attachment of spindle microtubules to kinetochore
GO:0045995regulation of embryonic development
GO:0007405neuroblast proliferation
GO:0006890retrograde vesicle-mediated transport, Golgi to ER
GO:0000915actomyosin contractile ring assembly
GO:0007018microtubule-based movement
GO:0051256mitotic spindle midzone assembly

Reactome


Reactome ID Description
R-HSA-983189Kinesins
R-HSA-6811434COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-194840Rho GTPase cycle
R-HSA-2132295MHC class II antigen presentation

KEGG



Field Data
Localization in this study: nucleus, plasma_membrane
Localization in the literature: nucleus, mitotic spindle, midbody

Confocal Images


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Cytochalasin D Screen Negative


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>RACGAP1
atggatactatgatgctgaatgtgcggaatctgtttgagcagcttgtgcgccgggtggag
attctcagtgaaggaaatgaagtccaatttatccagttggcgaaggactttgaggatttc
cgtaaaaagtggcagaggactgaccatgagctggggaaatacaaggatcttttgatgaaa
gcagagactgagcgaagtgctctggatgttaagctgaagcatgcacgtaatcaggtggat
gtagagatcaaacggagacagagagctgaggctgactgcgaaaagctggaacgacagatt
cagctgattcgagagatgctcatgtgtgacacatctggcagcattcaactaagcgaggag
caaaaatcagctctggcttttctcaacagaggccaaccatccagcagcaatgctgggaac
aaaagactatcaaccattgatgaatctggttccattttatcagatatcagctttgacaag
actgatgaatcactggattgggactcttctttggtgaagactttcaaactgaagaagaga
gaaaagaggcgctctactagccgacagtttgttgatggtccccctggacctgtaaagaaa
actcgttccattggctctgcagtagaccaggggaatgaatccatagttgcaaaaactaca
gtgactgttcccaatgatggcgggcccatcgaagctgtgtccactattgagactgtgcca
tattggaccaggagccgaaggaaaacaggtactttacaaccttggaacagtgactccacc
ctgaacagcaggcagctggagccaagaactgagacagacagtgtgggcacgccacagagt
aatggagggatgcgcctgcatgactttgtttctaagacggttattaaacctgaatcctgt
gttccatgtggaaagcggataaaatttggcaaattatctctgaagtgtcgagactgtcgt
gtggtctctcatccagaatgtcgggaccgctgtccccttccctgcattcctaccctgata
ggaacacctgtcaagattggagagggaatgctggcagactttgtgtcccagacttctcca
atgatcccctccattgttgtgcattgtgtaaatgagattgagcaaagaggtctgactgag
acaggcctgtataggatctctggctgtgaccgcacagtaaaagagctgaaagagaaattc
ctcagagtgaaaactgtacccctcctcagcaaagtggatgatatccatgctatctgtagc
cttctaaaagactttcttcgaaacctcaaagaacctcttctgacctttcgccttaacaga
gcctttatggaagcagcagaaatcacagatgaagacaacagcatagctgccatgtaccaa
gctgttggtgaactgccccaggccaacagggacacattagctttcctcatgattcacttg
cagagagtggctcagagtccacatactaaaatggatgttgccaatctggctaaagtcttt
ggccctacaatagtggcccatgctgtgcccaatccagacccagtgacaatgttacaggac
atcaagcgtcaacccaaggtggttgagcgcctgctttccttgcctctggagtattggagt
cagttcatgatggtggagcaagagaacattgaccccctacatgtcattgaaaactcaaat
gccttttcaacaccacagacaccagatattaaagtgagtttactgggacctgtgaccact
cctgaacatcagcttctcaagactccttcatctagttccctgtcacagagagtccgttcc
accctcaccaagaacactcctagatttgggagcaaaagcaagtctgccactaacctagga
cgacaaggcaacttttttgcttctccaatgctcaagttaatta

Protein Sequence

>RACGAP1
MDTMMLNVRNLFEQLVRRVEILSEGNEVQFIQLAKDFEDFRKKWQRTDHELGKYKDLLMK
AETERSALDVKLKHARNQVDVEIKRRQRAEADCEKLERQIQLIREMLMCDTSGSIQLSEE
QKSALAFLNRGQPSSSNAGNKRLSTIDESGSILSDISFDKTDESLDWDSSLVKTFKLKKR
EKRRSTSRQFVDGPPGPVKKTRSIGSAVDQGNESIVAKTTVTVPNDGGPIEAVSTIETVP
YWTRSRRKTGTLQPWNSDSTLNSRQLEPRTETDSVGTPQSNGGMRLHDFVSKTVIKPESC
VPCGKRIKFGKLSLKCRDCRVVSHPECRDRCPLPCIPTLIGTPVKIGEGMLADFVSQTSP
MIPSIVVHCVNEIEQRGLTETGLYRISGCDRTVKELKEKFLRVKTVPLLSKVDDIHAICS
LLKDFLRNLKEPLLTFRLNRAFMEAAEITDEDNSIAAMYQAVGELPQANRDTLAFLMIHL
QRVAQSPHTKMDVANLAKVFGPTIVAHAVPNPDPVTMLQDIKRQPKVVERLLSLPLEYWS
QFMMVEQENIDPLHVIENSNAFSTPQTPDIKVSLLGPVTTPEHQLLKTPSSSSLSQRVRS
TLTKNTPRFGSKSKSATNLGRQGNFFASPMLKLI

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