Field Data
UniProt Accession: Q9H7D0
Gene Name: DOCK5
Gene Synonim:
GAP/GEF: GEF
Description: Dedicator of cytokinesis protein 5
Keywords: Acetylation;Alternative splicing;Cell membrane;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome;SH3 domain
Entrez ID: 80005
Ensembl Gene ID: ENSG00000147459
Ensembl Protein ID: ENSP00000429737
Our Specificity
Literature Specificity None
Domain Composition:

Cellular Component


GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0016020membrane
GO:0005886plasma membrane

Molecular Function


GO ID Description
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process


GO ID Description
GO:0010634positive regulation of epithelial cell migration
GO:0043547positive regulation of GTPase activity
GO:1900026positive regulation of substrate adhesion-dependent cell spreading
GO:1904754positive regulation of vascular associated smooth muscle cell migration
GO:0007264small GTPase mediated signal transduction
GO:1904694negative regulation of vascular smooth muscle contraction

Reactome


Reactome ID Description
R-HSA-983231Factors involved in megakaryocyte development and platelet production

KEGG



Field Data
Localization in this study: focal_adhesions
Localization in the literature: plasma membrane focal adhesions

Confocal Images


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Cytochalasin D Screen Negative


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TIRF


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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>DOCK5
atggcccgctggatcccgaccaagaggcagaagtacggggttgcgatctataactacaat
gcttctcaagatgtggagctctccttgcagatcggtgacacagttcacatcctggagatg
tacgagggttggtacagaggatataccctccaaaataaatctaaaaagggcattttccct
gaaacatatatccatttgaaagaggcaactgtggaagacctggggcagcatgaaaccgtg
attcctggcgagctccccctggtgcaggagctcacgtccactctgcgagaatgggctgtc
atctggcgaaagctctacgtgaacaacaagctcaccctcttccgccagctgcagcagatg
acgtacagcctgatcgagtggcggtcccagatcctgtctgggacgctccccaaggatgaa
ctggcagagctcaagaagaaagtcacagccaaaattgatcatgggaacagaatgctgggg
ttagatctggtggtgcgagatgacaatgggaacatcctagaccctgacgaaaccagcacc
attgccctcttcaaggcccatgaggtggcctccaaaaggattgaggaaaagatccaagaa
gagaagtcaatcctgcagaacctcgatttgcggggccagtccatcttcagtaccatccac
acctatggcctctatgtgaacttcaagaactttgtctgcaacatcggggaagatgcagag
ttgtttatggccctctacgacccagaccagtccacttttatcagtgagaactatctaatt
cgttggggcagtaacgggatgcccaaggaaatagagaagctcaataacctccaagcagtg
tttacagaccttagcagcatggacctcatccggccccgcgtcagccttgtgtgccagatt
gtccgcgtgggccatatggagctgaaggaaggcaagaagcacacctgtggactccgaaga
ccttttggagtggcagtgatggatattactgatatcatacatgggaaggtggatgatgaa
gaaaagcagcattttattccctttcagcaaattgcgatggaaacctacatccgccagagg
cagctcatcatgtcgcctttgataacatcacacgtgattggggagaatgagccactcact
tcagtcttgaataaagtgattgcagcaaaggaagtgaatcacaaagggcaaggcctttgg
gtatccttgaagctcttgcccggtgacctcacccaggttcagaagaatttttcacacttg
gttgatagatcaacagcaatagcccggaagatgggctttcctgaaatcatactgccagga
gatgttcggaatgacatttatgtcaccctgatccacggtgagtttgacaaagggaagaag
aagacgccaaagaatgtggaggtgacgatgtctgtgcacgatgaggagggcaagctcttg
gagaaagcaattcaccctggtgctggatatgaaggcatttcagaatacaaatcagtagtc
tattaccaagtcaagcagccctgttggtatgagactgtcaaggtatccattgctatagaa
gaagtcacacgctgtcatataagatttaccttccgacacaggtcatctcaggaaaccaga
gataaatcggagcgagcatttggggtggccttcgtgaagctgatgaacccggatggcacc
actctgcaggatgggaggcacgatctggtggtttataagggtgacaacaaaaaaatggaa
gatgctaaattctacctgaccctgcctggaaccaagatggagatggaagaaaaagagctt
caagcatccaaaaacctggtcaccttcaccccaagcaaggatagcactaaagacagcttt
cagattgccaccctcatctgctccacaaagctcacccagaatgttgacctgttaggcttg
ttaaattggcgttccaactcccagaacattaaacacaacctaaagaagttaatggaagtg
gatggaggagagattgttaagtttttgcaagatacactagatgcactctttaacataatg
atggaaatgtcagacagtgaaacctatgacttccttgtgtttgacgcactggtatttatt
atttcactgataggagacatcaagttccagcattttaatcctgtacttgaaacctacatt
tacaagcacttcagcgccactttggcatatgtgaaactctccaaggtactgaacttctat
gtggctaatgcagatgactccagcaagactgaactgctttttgctgcgttgaaagccttg
aagtacttgtttagattcatcatccaatcccgagtgctctacttgagattttatgggcag
agcaaagatggagatgagtttaataattcaattcgccagttatttcttgctttcaatatg
ctgatggacaggcctctggaggaagccgtcaagatcaagggggcagctttgaagtacctt
cctagcataattaatgatgtcaaacttgtatttgatcctgttgagctcagcgtgctcttc
tgcaaattcattcaaagcattcctgacaaccagctggttcggcagaaacttaactgcatg
accaagatagtagagagcactctttttcgacagtcagagtgcagagaagtgctgctgcca
ctgctgacagaccagctcagcggccagttagatgacaactccaacaagcctgaccacgag
gcaagctcgcagcttctgagcaacatcctggaggtgctggacaggaaggatgtgggtgcc
actgcggtgcacattcagcttataatggaacggctgctgagaaggatcaaccggacagtg
attgggatgaaccggcagtctccccacatcgggagttttgtggcttgcatgattgccctg
ctgcagcaaatggacgacagccactatagccactacatcagcactttcaaaaccagacaa
gacatcatcgacttcctcatggaaacttttatcatgttcaaggacctgattggaaagaat
gtctatgccaaagattggatggtgatgaatatgactcaaaacagggtttttctccgtgct
ataaatcagtttgctgaagttctcacaagattcttcatggatcaggcaagctttgaactt
cagctctggaacaattacttccatttggcagttgcatttctcacccatgagtcccttcag
cttgaaaccttctcacaagccaagcgcaacaaaattgttaaaaaatatggggacatgaga
aaggaaatcggctttagaatccgggacatgtggtataacctgggtccccacaaaatcaaa
ttcatcccatccatggtgggtcccattctggaggtcactctgacccctgaagtagagctc
cggaaagccacaatccccattttctttgatatgatgcagtgtgagttcaatttcagtgga
aatggcaatttccatatgtttgagaatgagctgatcacaaagctggaccaggaggtagaa
gggggcagaggagacgaacaatacaaggttcttctggaaaaactgctcctagaacattgc
cggaaacacaaatacctctccagctctggggaggtcttcgccctcctggtcagcagcctc
ttagagaacctgctggactatagaaccatcatcatgcaagatgagagcaaggagaaccgt
atgagctgcactgtgaacgtgctgaacttttataaagaaaagaagagagaggacatatac
ataagatatctgtacaagcttcgagatttgcaccgagactgtgagaactacacagaagct
gcctacacgcttctcttgcacgctgagcttctgcagtggtctgacaagccctgtgtgcct
catttgcttcagaaggacagttactatgtttatacccagcaagagcttaaagagaagctg
tatcaagaaatcatatcatatttcgacaaaggcaaaatgtgggagaaggccatcaagctg
agcaaagagttggctgagacttacgaaagcaaagtatttgactacgagggccttggcaac
ctcctgaaaaaaagggcctcattttatgagaacatcattaaggcaatgaggcctcagcct
gaatactttgctgttggatactatggacagggctttccttctttcctacggaataaaatc
ttcatctatcggggaaaggagtatgagaggcgagaggacttcagcctgaggttgttaacc
cagttccccaatgcggagaagatgaccagtaccacgcctcctggggaagacatcaagtcg
tcccccaagcagtacatgcagtgcttcactgtaaagccagtgatgagcttgccgcccagc
tacaaggataaacctgttccagagcagatcttaaactactacagagccaatgaagtgcag
cagttcagatactcccggccgttccggaaaggagaaaaggatccagacaatgaatttgct
acgatgtggattgaacggaccacgtatacgactgcatatacctttcctgggattctcaag
tggtttgaagtcaaacagatttcaacagaagagatcagtcctctggagaatgccatcgaa
accatggagctgaccaacgagaggatcagcaactgtgttcagcagcatgcctgggaccgg
tccctctctgtgcaccctctctccatgctgctcagtggcatcgtggacccggccgtcatg
gggggcttctccaactatgaaaaggctttttttacagaaaagtacttgcaggagcatcct
gaagaccaggagaaggttgagctgctaaagcgactaatagcattacagatgcccctgcta
acagaagggatccgcatccatggggagaaactcacagagcagctgaagccgctgcatgag
cggttgtcttcttgcttccgggaactcaaggagaaagtagaaaagcactatggggttata
acactgccacccaacttgacggagaggaagcaaagccgcacggggtctattgtgctcccc
tacatcatgtcttccactctgcggaggttgtccatcacctcagtcacttcctctgtggtt
tccacctcttcaaactcgtctgacaatgctccttccagaccgggatctgatggctcaatc
ttggagccacttttggagcgcagggcctcgtcaggtgccagagttgaagatctgtccctt
agagaggagaacagcgagaaccggatcagcaagtttaagagaaaagactggagtctgagc
aagtcccaggtcattgcagagaaagcaccagaacccgatttgatgagcccaaccagaaaa
gcacaaaggccaaagagtctccagttgatggataatcggctatcaccatttcacggttct
tcacctcctcagtcaacacccttgagcccacctccactcactcccaaagccaccaggacc
ctaagctccccatcgttgcagacagatggaatcgcggccactcctgtcccacctccacct
ccccccaaaagcaagccctatgaaggcagccagaggaactccactgagctcgctccccca
ctgcctgtccgaagagaagccaaagcaccaccccctccacctccaaaggctcggaagtct
ggcatccctacttccgagcctggatcccagttaatta

Protein Sequence

>DOCK5
MARWIPTKRQKYGVAIYNYNASQDVELSLQIGDTVHILEMYEGWYRGYTLQNKSKKGIFP
ETYIHLKEATVEDLGQHETVIPGELPLVQELTSTLREWAVIWRKLYVNNKLTLFRQLQQM
TYSLIEWRSQILSGTLPKDELAELKKKVTAKIDHGNRMLGLDLVVRDDNGNILDPDETST
IALFKAHEVASKRIEEKIQEEKSILQNLDLRGQSIFSTIHTYGLYVNFKNFVCNIGEDAE
LFMALYDPDQSTFISENYLIRWGSNGMPKEIEKLNNLQAVFTDLSSMDLIRPRVSLVCQI
VRVGHMELKEGKKHTCGLRRPFGVAVMDITDIIHGKVDDEEKQHFIPFQQIAMETYIRQR
QLIMSPLITSHVIGENEPLTSVLNKVIAAKEVNHKGQGLWVSLKLLPGDLTQVQKNFSHL
VDRSTAIARKMGFPEIILPGDVRNDIYVTLIHGEFDKGKKKTPKNVEVTMSVHDEEGKLL
EKAIHPGAGYEGISEYKSVVYYQVKQPCWYETVKVSIAIEEVTRCHIRFTFRHRSSQETR
DKSERAFGVAFVKLMNPDGTTLQDGRHDLVVYKGDNKKMEDAKFYLTLPGTKMEMEEKEL
QASKNLVTFTPSKDSTKDSFQIATLICSTKLTQNVDLLGLLNWRSNSQNIKHNLKKLMEV
DGGEIVKFLQDTLDALFNIMMEMSDSETYDFLVFDALVFIISLIGDIKFQHFNPVLETYI
YKHFSATLAYVKLSKVLNFYVANADDSSKTELLFAALKALKYLFRFIIQSRVLYLRFYGQ
SKDGDEFNNSIRQLFLAFNMLMDRPLEEAVKIKGAALKYLPSIINDVKLVFDPVELSVLF
CKFIQSIPDNQLVRQKLNCMTKIVESTLFRQSECREVLLPLLTDQLSGQLDDNSNKPDHE
ASSQLLSNILEVLDRKDVGATAVHIQLIMERLLRRINRTVIGMNRQSPHIGSFVACMIAL
LQQMDDSHYSHYISTFKTRQDIIDFLMETFIMFKDLIGKNVYAKDWMVMNMTQNRVFLRA
INQFAEVLTRFFMDQASFELQLWNNYFHLAVAFLTHESLQLETFSQAKRNKIVKKYGDMR
KEIGFRIRDMWYNLGPHKIKFIPSMVGPILEVTLTPEVELRKATIPIFFDMMQCEFNFSG
NGNFHMFENELITKLDQEVEGGRGDEQYKVLLEKLLLEHCRKHKYLSSSGEVFALLVSSL
LENLLDYRTIIMQDESKENRMSCTVNVLNFYKEKKREDIYIRYLYKLRDLHRDCENYTEA
AYTLLLHAELLQWSDKPCVPHLLQKDSYYVYTQQELKEKLYQEIISYFDKGKMWEKAIKL
SKELAETYESKVFDYEGLGNLLKKRASFYENIIKAMRPQPEYFAVGYYGQGFPSFLRNKI
FIYRGKEYERREDFSLRLLTQFPNAEKMTSTTPPGEDIKSSPKQYMQCFTVKPVMSLPPS
YKDKPVPEQILNYYRANEVQQFRYSRPFRKGEKDPDNEFATMWIERTTYTTAYTFPGILK
WFEVKQISTEEISPLENAIETMELTNERISNCVQQHAWDRSLSVHPLSMLLSGIVDPAVM
GGFSNYEKAFFTEKYLQEHPEDQEKVELLKRLIALQMPLLTEGIRIHGEKLTEQLKPLHE
RLSSCFRELKEKVEKHYGVITLPPNLTERKQSRTGSIVLPYIMSSTLRRLSITSVTSSVV
STSSNSSDNAPSRPGSDGSILEPLLERRASSGARVEDLSLREENSENRISKFKRKDWSLS
KSQVIAEKAPEPDLMSPTRKAQRPKSLQLMDNRLSPFHGSSPPQSTPLSPPPLTPKATRT
LSSPSLQTDGIAATPVPPPPPPKSKPYEGSQRNSTELAPPLPVRREAKAPPPPPPKARKS
GIPTSEPGSQLI

  • Gold
  • Silver
  • Bronze
  • IntAct