Field Data
UniProt Accession: Q9H7P9
Gene Name: PLEKHG2
Gene Synonim:
GAP/GEF: GEF
Description: Pleckstrin homology domain-containing family G member 2 (PH domain-containing family G member 2)
Keywords: Alternative splicing;Complete proteome;Disease mutation;Guanine-nucleotide releasing factor;Leukodystrophy;Mental retardation;Phosphoprotein;Polymorphism;Reference proteome;Tumor suppressor
Entrez ID: 64857
Ensembl Gene ID: ENSG00000090924
Ensembl Protein ID: ENSP00000392906
Our Specificity
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043065positive regulation of apoptotic process
GO:0051056regulation of small GTPase mediated signal transduction
GO:0030833regulation of actin filament polymerization
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: actin
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>PLEKHG2
atgcccgagggagcccggggattgagcctgcccaaacccagccttaggctcgggtgtggc
caccaaggtgaagtttgcgactgcgcagcagtgagtgacactccaacagcagcgcaggca
gccaccaccatggcttctccaaggggttctggcagctccacttcgttgagcactgtgggc
tccgagggggacccatctccagcctgctcagcctccaggccagagcccctaccggagccc
cccatacgcctgcacctgttgcctgtgggaatccagggttcggtgaaaccctccaggctg
gaacgagtggccagggagattgtggagacagagcgggcgtatgttcgcgaccttcgcagc
atcgtggaggactacctaggccctctgatggatggcagggccctggggctgaacatggag
caggtgggcacactgtttgccaacatcgaggacatctatgagtttagcagtgagctcctg
gaggacttggaaggctgcagcagtgcagggggcatcgccgagtgcttcgtgcaaagaagc
gaagattttgacatctatacattgtactgcatgaactacccaagctccctggccctgctc
cgagagctgtcagtgtccccgccagccactctgtggctacaggagcgtcaggcccagctc
cgtcactccctgcctctgcagagcttcttgctgaagcctgttcagcgcatcctgaagtac
catctcctgctgcaggaactgggcaagcactgggcagagggcccagacagtggagggcga
gagatggtggaggaagccattgtatccatgactgcagtggcctggtacatcaatgacatg
aagcgcaagcaagagcatgctgcacgcctgcaggaagtgcagcggaggctgggtggctgg
actggcccggagctcagcgcctttggagagctagtactggaaggcactttccgaggggga
ggcgggggaggccccaggcttcgtgggggtgagcgcctcctcttcttgttctcccggatg
ctgctggttgccaagcgtcgggggcctgaatacacctacaagggccacatcttttgctgt
aacctcagcgtaagcgagactccgcgggaccccttaggatttaaggtgtcagacctgacc
atccccaagcacagacacctgttccaggccaagaaccaggaagagaaacggctgtggatc
cactgtctccagcgcctcttctttgagaaccacccggcttccatccctgccaaggcaaag
caagttctcttggaaaacagcctacattgtgctccaaagagcaaacatatcccagaaccc
ccaacatccccactggactctccccgacctcgagatgctccaggttttacccccggcaga
agaaacccagctccatctccaagactttctggcagtcgccgtggccgcaggcagtctgag
ccagcaaaggaagcttatgtcatttttccccagaatgataagcctcaagtcaagcatgct
ggcagtgaaggagagctccacccctcatctgagctgcagccagtgtctgcttctggccct
cctgaagacctggaggatgctgggcctcccacgttggacccgtcggggacttccataact
gaggagatcctagaactgctgaaccagagaggcctcagggactcggggccagccacccac
gacattcccaagttccccagagactcccgggtgccagttgaaagcgaacccctcccgttc
caatccctgcccagccgagagtcttcagaagaggaggaggaggaggacctggagacagat
gaacgcgagccttccccactgcacgtcttagaggggctggaaggttcgagcgcagctgaa
attccctgcattcccagccttactgacattcccagtgaagtgcccagccttccagaaatt
cctgaggctccctgccttccctgtctctctgatatctctggtgtttttgaggtaccctgc
ctttcacccacatccactgtgcctgacattcccagcttggccaccaccccctcctttccc
tgtggctcctggctccctggacccctgcaggaggcagcccagcctcaagccaccaggagg
gaactgttgagtgggagcaatccaggaagactgagtgagtccccctcagaaagcagagag
gggcaggaggatgacacagaaggcgtgtcattctcagctgtgcagagggaggctggcacc
tcggtccaaggattcccggaagaactggaataccgctcttgttcagaaatccggagtgcc
tggcaagctctggagcaggggcagctggcccggcctggcttcccagaacctctgctcatc
ctggaggactctgatcttagaggaggcagcaccagcgggaagacaggaatgccacattca
gagcggtcagcatcgcgggtgcgagagttggctcggctctacagtgagcgtatccagcag
atgcaacgagctgagactagggcatccaccaatgcaccccgccgcagacctcgagtcctg
gcccaaccccagccatccccttgcccaccccaggaagaggctgaaccaggggccctgcct
gcatttggacatgtgcttgtatgtgagctggctttcccactgaactgcacccaggagtct
gtccctctgggccctgctgttctggttcaagctgccacacctttgtgtattcaaggagat
gacctgagtggccagaatctaaatgtttcagatttgtccaagcaaggccatctgagtagt
aactccattccaccgcctgtccctttacctgggcaaagcaacttccagaacatacaggtt
ccctctacatcccttttgcctaagcaagagcctccagatgtccaggtcccaactgcctca
accttgcctgatacaagccagctccaaagccaagttcccgctgccactccatcagctggg
catagaaactgtgtggagatccaggttcagtccaccacctcccttcctggccaagagtgt
caggcagacactgtggcattgtccaagcaagaaggtcatgaagacagccagaacccaaac
aaggccccaggagccgagcaaagagacgtcagcattgatcagggtctagctgttgttggt
ggccggcctgtcagccctttgccagtgtgcacaagtagccctgaccagcagatcccagcc
accaccccactgccattgtcaactgacttcccagacatggagggtcctggtgccttacct
ctgcccacacaggaaggtcgtccggactgcagcatcccatgcaaccctctaccatctttg
tcccaagacgttcaggtgccagcggtcatccctgtgtcccagctgcaaggccttacagac
accagggccacagtgcccctgtcttcccacaagcaggaggacgctccagagtgtctgggt
ccagagcccagcctcacagacacaccagctcccagactcttatcttcactgggccaacag
aacaccacagatggccctgtttcagcagctgccgtgcctttgactgaacaaggatgctct
caggatctgcaaggcctaattacttccccagttcagacaaccatggagttacccaaacca
aggggtttagtctctcgtgttgccacctcagagtctttggacttgaccccaccgcatagc
ccctcgctctccactcgccagctcctgggccccagtgcagctgccctttcaaggtacctg
gcagcttcatacatcagccagagcttggctaggcgccagggacctgggggagagggcacg
gtagcctcccagggtcactggtcctcctctgcccccacatcacgggcaccttcaccacca
cctcagccccagcccccagcccctccagccaggaggctcagctatgccaccacagttagt
attcaggtaggaggtggtgggcggctacgaccagccaaagctcaggtccggctaaaccac
cctgctctcttggcagcccctcacccgggagccgttgggccttcccagggcccaggaggc
tcct

Protein Sequence

>PLEKHG2
MPEGARGLSLPKPSLRLGCGHQGEVCDCAAVSDTPTAAQAATTMASPRGSGSSTSLSTVG
SEGDPSPACSASRPEPLPEPPIRLHLLPVGIQGSVKPSRLERVAREIVETERAYVRDLRS
IVEDYLGPLMDGRALGLNMEQVGTLFANIEDIYEFSSELLEDLEGCSSAGGIAECFVQRS
EDFDIYTLYCMNYPSSLALLRELSVSPPATLWLQERQAQLRHSLPLQSFLLKPVQRILKY
HLLLQELGKHWAEGPDSGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGW
TGPELSAFGELVLEGTFRGGGGGGPRLRGGERLLFLFSRMLLVAKRRGPEYTYKGHIFCC
NLSVSETPRDPLGFKVSDLTIPKHRHLFQAKNQEEKRLWIHCLQRLFFENHPASIPAKAK
QVLLENSLHCAPKSKHIPEPPTSPLDSPRPRDAPGFTPGRRNPAPSPRLSGSRRGRRQSE
PAKEAYVIFPQNDKPQVKHAGSEGELHPSSELQPVSASGPPEDLEDAGPPTLDPSGTSIT
EEILELLNQRGLRDSGPATHDIPKFPRDSRVPVESEPLPFQSLPSRESSEEEEEEDLETD
EREPSPLHVLEGLEGSSAAEIPCIPSLTDIPSEVPSLPEIPEAPCLPCLSDISGVFEVPC
LSPTSTVPDIPSLATTPSFPCGSWLPGPLQEAAQPQATRRELLSGSNPGRLSESPSESRE
GQEDDTEGVSFSAVQREAGTSVQGFPEELEYRSCSEIRSAWQALEQGQLARPGFPEPLLI
LEDSDLRGGSTSGKTGMPHSERSASRVRELARLYSERIQQMQRAETRASTNAPRRRPRVL
AQPQPSPCPPQEEAEPGALPAFGHVLVCELAFPLNCTQESVPLGPAVLVQAATPLCIQGD
DLSGQNLNVSDLSKQGHLSSNSIPPPVPLPGQSNFQNIQVPSTSLLPKQEPPDVQVPTAS
TLPDTSQLQSQVPAATPSAGHRNCVEIQVQSTTSLPGQECQADTVALSKQEGHEDSQNPN
KAPGAEQRDVSIDQGLAVVGGRPVSPLPVCTSSPDQQIPATTPLPLSTDFPDMEGPGALP
LPTQEGRPDCSIPCNPLPSLSQDVQVPAVIPVSQLQGLTDTRATVPLSSHKQEDAPECLG
PEPSLTDTPAPRLLSSLGQQNTTDGPVSAAAVPLTEQGCSQDLQGLITSPVQTTMELPKP
RGLVSRVATSESLDLTPPHSPSLSTRQLLGPSAAALSRYLAASYISQSLARRQGPGGEGT
VASQGHWSSSAPTSRAPSPPPQPQPPAPPARRLSYATTVSIQVGGGGRLRPAKAQVRLNH
PALLAAPHPGAVGPSQGPGGS

  • Gold
  • Silver
  • Bronze
  • IntAct