Field Data
UniProt Accession: Q9HCE6
Gene Name: ARHGEF10L
Gene Synonim: GRINCHGEF, KIAA1626
GAP/GEF: GEF
Description: Rho guanine nucleotide exchange factor 10-like protein (GrinchGEF)
Keywords: Alternative splicing;Complete proteome;Cytoplasm;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 55160
Ensembl Gene ID: ENSG00000074964
Ensembl Protein ID: ENSP00000364564
Our Specificity
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

Reactome ID Description
R-HSA-416482G alpha (12/13) signalling events
R-HSA-194840Rho GTPase cycle
R-HSA-193648NRAGE signals death through JNK

KEGG

Field Data
Localization in this study: cytosolic
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGEF10L
atggcttcctccaaccctcctccacagcctgccataggagatcagctggttccaggagtc
ccaggcccctcctctgaggcagaggacgacccaggagaggcgtttgagtttgatgacagt
gatgatgaagaggacaccagcgcagccctgggcgtccccagccttgctcctgagagggac
acagaccccccactgatccacttggactccatccctgtcactgacccagacccagcagct
gctccacccggcacaggggtgccagcctgggtgagcaatggggatgcagcggacgcagcc
ttctccggggcccggcactccagctggaagcggaagagttcccgtcgcattgaccggttc
actttccccgccctggaagaggatgtgatttatgacgacgtcccctgcgagagcccagat
gcgcatcagcccggggcagagaggaacctgctctacgaggatgcgcaccgggctggggcc
cctcggcaggcggaggacctaggctggagctccagtgagttcgagagctacagcgaggac
tcgggggaggaggccaagccggaggtcgaggtcgagcccgccaagcaccgagtgtccttc
cagcccaagctttctccagacctgactaggctaaaggagagatacgccaggactaagaga
gacatcttggctttgagagttggggggagagacatgcaggagctgaagcacaagtacgat
tgtaagatgacccagctcatgaaggccgccaagagcgggaccaaggatgggctggagaag
acacggatggccgtgatgcgcaaagtctccttcctgcacaggaaggacgtcctcggtgac
tcggaggaggaggacatggggctcctggaggtcagcgtttcggacatcaagcccccagcc
ccagagctgggccccatgccagagggcctgagccctcagcaggtggtccggaggcatatc
ctgggctccatcgtgcagagcgaaggcagctacgtggagtctctgaagcggatactccag
gactaccgcaaccccctgatggagatggagcccaaggcgctgagcgcccgcaagtgccag
gtggtgttcttccgcgtgaaggagatcctgcactgccactccatgttccagatcgccctg
tcctcccgcgtggctgagtgggattccaccgagaagatcggggacctcttcgtggcctcg
ttttccaagtccatggtgctagatgtgtacagtgactacgtgaacaacttcaccagtgcc
atgtccatcatcaagaaggcctgcctcaccaagcctgccttcctcgagttcctcaagcga
cggcaggtgtgcagcccagaccgtgtcaccctctacgggctgatggtcaagcccatccag
aggttcccacagttcatactcctgcttcaggacatgctgaagaacacccccaggggccat
ccggacaggctgtcgctgcagctggccctcacagagctggagacgctggctgagaagctg
aacgagcagaagcggctggctgaccaggtggctgagatccagcagctgaccaagagcgtc
agtgaccgcagcagcctcaacaagctgttgacctcaggccagcggcagctgctcctgtgt
gagacgttgacggagaccgtgtacggtgaccgcgggcagctaattaagtccaaggagcgt
cgggtcttcctgctcaacgacatgcttgtctgtgccaacatcaacttcaagcctgccaac
cacaggggccagctggagattagcagcctggtgcccctggggcccaagtatgtggtgaag
tggaacacggcgctgccccaggtgcaggtggtggaggtgggccaggacggtggcacctat
gacaaggacaatgtgctcatccagcactcaggcgccaagaaggcctctgcctcagggcag
gctcagaataaggtgtacctcggccccccacgcctcttccaggagctgcaggacctgcag
aaggacctggccgtggtggagcagatcacgcttctcatcagcacgctgcacggcacctac
cagaacctgaacatgactgtggctcaagactggtgcctggccctgcagaggctgatgcgg
gtgaaggaggaagagatccactcggccaacaagtgccgtctcaggctcctgcttcctggg
aaacccgacaagtccggccgccccattagcttcatggtggttttcatcacccccaacccc
ctgagcaagatttcctgggtcaacaggttacatttggccaaaatcggactccgggaggag
aaccagccaggctggctatgcccggatgaggacaagaagagcaaagccccattctggtgc
ccgatcctggcctgctgcatccctgccttctcctcccgggcactcagcctgcagcttggg
gccctggtccacagtcctgtcaactgtcccctgctgggtttctcagcagtcagcacctcc
cttccacagggctacctctgggtcgggggcggacaggaaggcgcagggggccaggtggaa
atcttttccttgaaccggccctcgccccgcaccgtcaagtccttcccactggcagcccct
gtgctctgcatggagtatatcccggagctggaggaggaggcggagagcagagacgagagc
ccgacagttgctgacccctcggccacggtgcatccaaccatctgcctcgggctccaggat
ggcagcatcctcctctacagcagtgtggacactggcacccagtgcctggtgagctgcagg
agcccaggtctgcagcctgtgctctgcctgcgacacagccccttccacctgctcgctggc
ctgcaggatgggacccttgctgcttaccctcggaccagcggaggtgtcctgtgggacctg
gagagccctcccgtgtgcctgactgtggggcccgggcctgtccgcaccctgttgagcctg
gaggatgccgtgtgggccagctgtgggccccgggtcactgtcctggaagccaccaccctg
cagcctcagcaaagcttcgaggcgcaccaggacgaggcagtgagcgtgacacacatggtg
aaggcgggcagcggcgtctggatggccttctcctccggcacctccatccgcctcttccac
actgagaccctggagcatctgcaagagatcaacatcgccaccaggaccaccttcctcctg
ccaggccagaagcacttgtgtgtcaccagcctcctgatctgccagggtctgctctgggtg
ggcactgaccagggtgtcatcgtcctgctgcccgtgcctcggctggaaggcatccccaag
atcacagggaaaggcatggtctcactcaatgggcactgtgggcctgtggccttcctggct
gtggctaccagcatcctggcccctgacatcctgcggagtgaccaggaggaggctgagggg
ccccgggctgaggaggacaagccagacgggcaggcacacgagcccatgcccgacagccac
gtgggccgagagctgacccgcaagaagggcatcctcttgcagtaccgcctgcgctccacc
gcacacctcccgggcccgctgctctccatgcgggagccggcgcctgctgatggcgcagct
ttggagcacagcgaggaggacggctccatttacgagatggccgacgaccccgacgtctgg
gtgcgcagccggccctgcgcccgcgacgcccaccgcaaggagatttgctctgtggccatc
atctccggcgggcagggctaccgcaactttggcagcgctctgggcagcagtgggaggcag
gccccgtgtggggagacggacagcaccctcctcatctggcaggtgcccttgatgctat

Protein Sequence

>ARHGEF10L
MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERD
TDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRF
TFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSED
SGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYD
CKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPA
PELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQ
VVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSA
MSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGH
PDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLC
ETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVK
WNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQ
KDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPG
KPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWC
PILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVE
IFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQD
GSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDL
ESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMV
KAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWV
GTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEG
PRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAA
LEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQ
APCGETDSTLLIWQVPLML

  • Gold
  • Silver
  • Bronze
  • IntAct