Field Data
UniProt Accession: Q9NZM3
Gene Name: ITSN2
Gene Synonim: KIAA1256, SH3D1B, SWAP
GAP/GEF: GEF
Description: Intersectin-2 (SH3 domain-containing protein 1B) (SH3P18) (SH3P18-like WASP-associated protein)
Keywords: 3D-structure;Alternative splicing;Calcium;Coiled coil;Complete proteome;Cytoplasm;Differentiation;Endocytosis;Metal-binding;Phosphoprotein;Polymorphism;Reference proteome;Repeat;SH3 domain
Entrez ID: 50618
Ensembl Gene ID: ENSG00000198399
Ensembl Protein ID: ENSP00000384499
Our Specificity
Literature Specificity Cdc42
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005813centrosome
GO:0070062extracellular exosome

Molecular Function

GO ID Description
GO:0005070SH3/SH2 adaptor activity
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0046872metal ion binding
GO:0005509calcium ion binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0006897endocytosis
GO:0043547positive regulation of GTPase activity
GO:0009967positive regulation of signal transduction
GO:0030154cell differentiation
GO:0035023regulation of Rho protein signal transduction
GO:1903861positive regulation of dendrite extension

Reactome

Reactome ID Description
R-HSA-8856825Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828Clathrin-mediated endocytosis

KEGG

Field Data
Localization in this study: actin, focal_adhesions, vesicles
Localization in the literature: vesicles

Confocal Images

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ITSN2
atggctcagtttcccacagctatgaatggagggccaaacatgtgggctattacctctgaa
gaacgtactaagcatgacaggcagtttgataacctcaaaccttcaggaggttacataaca
ggtgatcaagcacgtaattttttcctacaatcaggtctgccggcccctgttttagctgaa
atatgggctttatcagacctaaacaaggatgggaagatggatcagcaagagttctccata
gctatgaaactcatcaaactgaagcttcaaggccaacagttgcctgtggttctccctcct
attatgaagcaaccccctatgttttctccattaatttctgctcgttttggaatgggaagc
atgcccaatctgtccattcctcagccattgcctccagctgcacctataacatcattgtct
tctgcgacttcagggaccaaccttcctcccttaatgatgcccactcccctagtgccttct
gttagcacatcatcattaccaaatggaaccgccagtctcattcagcctttacccattcct
tattcttcttcaacattgcctcatgggtcatcttatagtctgatgatgggaggatttgga
ggtgctagtatacagaaagcgcagtctctgattgatttaggatctagtagctcaacttcc
tcgactgcttcactctcagggaactcacccaagactgggacctcagagtgggcagttcct
cagcctacaagattaaaatatcggcaaaaatttaatactcttgacaaaagtatgagtgga
tatctctcaggttttcaagctagaaatgcccttcttcagtcaaatctttctcaaactcag
ctggctactatttggactctggctgacgttgatggtgatggacagctaaaagcagaagag
tttattcttgcaatgcaccttactgacatggccaaagctggacagccattaccactgact
ttacctcctgagcttgttcctccatctttcagaggaggaaagcaaattgattccattaat
ggaactctgccttcatatcagaaaatgcaagaagaggagcctcagaagaaattaccagtt
acttttgaggacaaacggaaagccaactatgagcgagggaacatggagctggaaaagcga
cgccaagccttgatggagcagcaacaaagggaggcagaacgtaaagcccagaaagaaaag
gaagagtgggaacgaaaacagagagaattacaagaacaagaatggaagaaacaacttgaa
ttagaaaaacgcttagagaagcaacgggaattggagagacaacgagaggaagaaaggaga
aaagacatagaaagacgagaggcagcaaaacaggaacttgaacgacaacgtcgcttagaa
tgggagagaattcggcgacaggagcttctcaatcaaaagaatagagaacaagaagaaatt
gtcaggttaaactctaaaaagaagaatcttcatcttgagttggaagcactgaatggcaaa
catcagcagatctcaggcagacttcaggatgtccgactcaaaaagcaaactcaaaagact
gagctggaagttctggataagcagtgtgacttggaaattatggaaatcaagcaacttcaa
caggaacttcaggaatatcagaataagcttatctatctggtacctgagaagcaattatta
aatgaaagaattaaaaacatgcagttcagtaacacacctgattcaggggtcagtttactt
cataaaaaatcattagaaaaggaagaattatgccaaagacttaaagaacagttagatgct
cttgaaaaagaaactgcatctaagctgtcagaaatggattcttttaacaatcaactaaag
gaactgagagaaacctacaacacacagcagttagcccttgaacagctttataagatcaaa
cgtgacaagttgaaggaaattgaaaggaaaagattagaactaatgcagaaaaagaaacta
gaagatgaggctgcaaggaaagcaaagcaaggaaaagaaaacttatggaaagaaaatctt
agaaaggaggaagaagaaaaacaaaagcgactccaggaagaaaaaacacaagaaaaaatt
caagaagaggaacggaaagctgaggagaaacaacgtaaggataaggatactttgaaagct
gaggagaaaaaacgtgagacagctagtgttttggtgaattatagagcattataccccttt
gaagcaaggaaccatgatgagatgagttttaattctggagatataattcaggttgatgaa
aaaaccgtaggagaacctggttggctttatggtagttttcaaggaaattttggctggttt
ccatgcaattatgtagaaaaaatgccatcaagtgaaaatgaaaaagctgtatctccaaag
aaggccttacttcctcctacagtttctttatctgctacctcaacttcctctgaaccactt
tcttcaaatcaaccagcatcagtgactgattatcaaaatgtatctttttcaaacctaact
gtaaatacatcatggcagaaaaaatcagccttcactcgaactgtgtcccctggatctgta
tcacctattcatggacagggacaagtggtagaaaacttaaaagcacaggccctttgttcc
tggactgcaaagaaagataaccacttgaacttctcaaaacatgacattattactgtcttg
gagcagcaagaaaattggtggtttggggaggtgcatggaggaagaggatggtttcccaaa
tcttatgtcaagatcattcctgggagtgaagtaaaacgggaagaaccagaagctttgtat
gcagctgtaaataagaaacctacctcggcagcctattcagttggagaagaatatattgca
ctttatccatattcaagtgtggaacctggagatttgactttcacagaaggtgaagaaata
ttggtgacccagaaagatggagagtggtggacaggaagtattggagatagaagtggaatt
tttccatcaaactatgtcaaaccaaaggatcaagagagttttgggagtgctagcaagtct
ggagcatcaaataaaaaacctgagattgctcaggtaacttcagcatatgttgcttctggt
tctgaacaacttagccttgcaccaggacagttaatattaattctaaagaaaaatacaagt
gggtggtggcaaggagagttacaggccagaggaaaaaagcgacagaaaggatggtttcct
gccagtcatgttaaacttttgggtccaagtagtgaaagagccacacctgcctttcatcct
gtatgtcaggtgattgctatgtatgactatgcagcaaataatgaagatgagctcagtttc
tccaagggacaactcattaatgttatgaacaaagatgatcctgattggtggcaaggagag
atcaacggggtgactggtctctttccttcaaactacgttaagatgacgacagactcagat
ccaagtcaacagtggtgtgctgatctgcaaaccctggacacaatgcagccaattgagagg
aaaagacagggctatattcatgagctgattcagaccgaagagcggtacatggctgacctt
cagctcgtcgtcgaggtttttcagaaacgcatggcagagtcaggctttctcactgaaggg
gagatggccctgatttttgttaactggaaggagctcatcatgtccaacacaaagctgctg
aaggctttgcgggtgcggaagaagaccgggggcgagaagatgccggtgcagatgattggg
gacatcctggccgctgagctgtcccacatgcaggcttacatcaggttctgcagctgccag
cttaatggagcagctctgttacagcagaagacagatgaagacacagatttcaaagaattt
ttaaagaagctggcatctgacccgcggtgtaaaggaatgcccctctccagcttcctgctg
aaacccatgcagaggatcacccgctacccactgctcatcagaagtattctggagaacacc
ccggagagccatgcagaccattcctccctaaagctggccctcgagcgggcagaggagctg
tgctctcaagtgaatgagggagttcgggagaaggaaaactcggaccgactggagtggatc
caggcgcacgtgcagtgtgaaggcctcgcggagcaacttattttcaactctctcaccaac
tgcctggggccccggaagctcttacacagtgggaaattatacaagaccaagagcaacaag
gaactgcacggattcctcttcaatgacttcctgcttcttacctacatggtcaagcagttt
gctgtttcctctggctctgagaaacttttcagctcgaagtccaatgctcaattcaaaatg
tataaaacgcccattttcctgaatgaagtcttggtgaaactgcccacagacccttccagc
gatgagcctgtcttccacatttcccacattgatcgggtctacaccctccgaacagacaac
attaatgagaggaccgcctgggtgcagaagatcaaggcggcgtctgagcagtacatcgac
accgagaagaagcagcgtgagaaagcttaccaagcccgctcccaaaagacttcaggcatt
gggcgcctgatggtgcatgtcattgaagctacagaattaaaagcctgcaaaccaaatgga
aagagcaacccatactgtgaaatcagcatgggctcccagagctacaccaccaggaccatc
caggacacactcaatcccaagtggaattttaactgccagttctttattaaggatctctac
caagacgtgctgtgtctcaccctgtttgacagagaccagttttcaccagatgatttcctg
ggtcgtactgaaattccagtggcaaaaattcgaacagaacaggaaagcaaaggccctatg
acccgccgactgctgctgcatgaggtccccaccggggaggtctgggtccgttttgacctg
cagctttttgagcaaaaaactctcctgttgatta

Protein Sequence

>ITSN2
MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE
IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS
MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIP
YSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVP
QPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEE
FILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPV
TFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLE
LEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEI
VRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ
QELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDA
LEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL
EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA
EEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWF
PCNYVEKMPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT
VNTSWQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL
EQQENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIA
LYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKS
GASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFP
ASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE
INGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADL
QLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIG
DILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLL
KPMQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWI
QAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQF
AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN
INERTAWVQKIKAASEQYIDTEKKQREKAYQARSQKTSGIGRLMVHVIEATELKACKPNG
KSNPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFL
GRTEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQKTLLLI

  • Gold
  • Silver
  • Bronze
  • IntAct