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Cellular Component

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GO ID	Description
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular exosome

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Molecular Function

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GO ID	Description
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0001664	G-protein coupled receptor binding
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0005096	GTPase activator activity

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Biological Process

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GO ID	Description
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0043065	positive regulation of apoptotic process
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0007186	G-protein coupled receptor signaling pathway

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Reactome

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Reactome ID	Description
R-HSA-416572	Sema4D induced cell migration and growth-cone collapse
R-HSA-416482	G alpha (12/13) signalling events
R-HSA-194840	Rho GTPase cycle
R-HSA-193648	NRAGE signals death through JNK

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KEGG

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Kegg ID	Description
hsa04611	Platelet activation
hsa05205	Proteoglycans in cancer
hsa05200	Pathways in cancer
hsa05152	Tuberculosis
hsa04360	Axon guidance
hsa04810	Regulation of actin cytoskeleton
hsa04270	Vascular smooth muscle contraction

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Field	Data
Localization in this study:	cytosolic
Localization in the literature:	cytosolic focal adhesions