Field Data
UniProt Accession: Q9P107
Gene Name: GMIP
Gene Synonim:
GAP/GEF: GAP
Description: GEM-interacting protein (GMIP)
Keywords: 3D-structure;Alternative splicing;Coiled coil;Complete proteome;GTPase activation;Metal-binding;Phosphoprotein;Polymorphism;Reference proteome;Zinc;Zinc-finger
Entrez ID: 51291
Ensembl Gene ID: ENSG00000089639
Ensembl Protein ID: ENSP00000467054
Our Specificity Cdc42, RhoA, Rac1
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005654nucleoplasm
GO:0005829cytosol
GO:0005886plasma membrane
GO:0005622intracellular

Molecular Function

GO ID Description
GO:0046872metal ion binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035556intracellular signal transduction
GO:0007165signal transduction
GO:0051056regulation of small GTPase mediated signal transduction
GO:0034260negative regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: puncta
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>GMIP
atggacgcagcagagccgggactccccccaggtcctgagggcaggaagaggtacagtgac
atcttccggagcctggacaacctcgaaatctcactggggaacgtgacccttgagatgctg
gctggagaccctctactctcagaagacccagaacctgacaagacccctacagccactgtt
accaacgaagccagctgttggagcggcccctccccagagggtcctgtacccctcacaggg
gaggaactggacttgcggctcattcggacaaaggggggtgtggacgcagccctggaatat
gccaagacctggagccgctatgccaaggaactgcttgcctggactgaaaagagagccagc
tatgagctggagtttgctaagagcaccatgaagatcgctgaagctggcaaggtgtccatt
caacagcagagccacatgcctctgcagtacatctacaccctgtttctggagcacgatctc
agcctgggaaccctggccatggagacagtggcccagcagaaaagagactactaccagccc
ctcgccgccaaacggactgagattgagaagtggcggaaggagttcaaggagcagtggatg
aaggagcagaagcggatgaatgaggcggtgcaggcactgcggcgcgcccagctgcagtat
gtgcaacgcagcgaggacctgcgggcacgctcccaggggtcccctgaggactcggccccc
caggcctcgccgggacctagcaagcagcaggagcggcggcggcgctcgcgagaggaggcc
caggccaaggcgcaggaggccgaggcgctgtaccaggcctgtgtccgcgaggccaacgcg
cggcagcaggacctggagatcgccaagcagcgaatcgtgtcgcacgtgcgcaagctggtg
tttcagggggatgaagtgctgaggcgggtgacgctgagtctcttcgggctgcggggggcg
caggcagagcgtggcccccgcgccttcgccgccctggccgagtgctgtgcgccctttgag
ccgggccagcgctaccaggagtttgtacgggcgctgcggcccgaggccccgccgcccccg
ccgcccgccttctccttccaggagttccttccctccttgaacagctcccctctggacatc
agaaagaagctctctgggcctcttcctccaaggctggatgagaattcagctgagccaggc
ccttgggaggatccgggcacaggctggcgctggcaagggactccaggccccactccgggc
agcgatgtggacagcgtgggtggcggcagcgagtctcggtccctggactcacccacttcc
agcccaggcgctggcacgaggcagctggtgaaggcttcgtccacaggcactgagtcctca
gatgactttgaggagcgagaccctgacctgggagacgggctggagaatgggctgggcagc
cccttcgggaagtggacactgtccagcgcggctcagacccaccagctgcggcgactgcgg
ggcccagccaagtgccgcgagtgcgaagccttcatggtcagcgggacggagtgtgaggag
tgctttctgacctgccacaagcgctgcctggagactctcctgatcctctgtggacacagg
cggctcccagcccggacacccctttttggggttgacttcctgcagctacccagggacttc
ccggaggaggtaccctttgtggtcacgaagtgcacggctgagatagaacaccgtgccctg
gatgtgcagggcatttaccgggtcagcgggtcccgggtccgtgtggagcggctgtgccag
gctttcgagaatggccgagcgttggtggagctgtcggggaactcgcctcatgacgtctcg
agtgtcctcaagcgatttcttcaggagctcaccgagcccgtgatccccttccacctctac
gacgccttcatctctctggctaagaccttgcatgcagaccctggggacgaccctgggacc
cccagccccagccctgaggttatccgctcgctgaagaccctcttggtacagctgcctgac
tctaactacaacaccctgcggcacctggtggcccatctgttcagggtggctgcacgattt
atggaaaacaagatgtctgccaacaacctgggcattgtgtttgggccgacactgctgcgg
ccgccggacggcccgcgggcagccagcgccatccctgtcacctgcctgctggactctggg
catcaggcccagcttgtggagttcctcatcgtgcactacgagcagatctttgggatggat
gagctcccccaggccactgagcccccgccccaagactccagcccagcccctgggcccctc
acaaccagctcccaaccgccacccccgcaccttgacccagactcccagcccccagtccta
gcctcagaccccggcccagacccccagcaccacagtaccctggagcagcatcccacggcc
acacctaccgagattccaactccacagagtgaccagagagaggacgtggctgaagacacc
aaagatgggggaggggaagtgtccagccaaggcccagaggactcactcctggggacacag
tctcgtggccacttcagccgccagccagtgaagtatccccggggcggtgtgaggcctgta
acccaccagctgtccagtctggccctggtggcttccaagctgtgcgaggagacccccatc
acatcagtgcccagagggagtttgcgggggcgggggcccagccctgcagctgcctcccct
gagggcagccccctgcgccgcaccccgctgcccaagcattttgagattacccaggagaca
gcccggctactctcgaaattggacagcgaggctgtgcccagggccacctgctgcccggac
gtccagcctgaggaagccgaggaccatctct

Protein Sequence

>GMIP
MDAAEPGLPPGPEGRKRYSDIFRSLDNLEISLGNVTLEMLAGDPLLSEDPEPDKTPTATV
TNEASCWSGPSPEGPVPLTGEELDLRLIRTKGGVDAALEYAKTWSRYAKELLAWTEKRAS
YELEFAKSTMKIAEAGKVSIQQQSHMPLQYIYTLFLEHDLSLGTLAMETVAQQKRDYYQP
LAAKRTEIEKWRKEFKEQWMKEQKRMNEAVQALRRAQLQYVQRSEDLRARSQGSPEDSAP
QASPGPSKQQERRRRSREEAQAKAQEAEALYQACVREANARQQDLEIAKQRIVSHVRKLV
FQGDEVLRRVTLSLFGLRGAQAERGPRAFAALAECCAPFEPGQRYQEFVRALRPEAPPPP
PPAFSFQEFLPSLNSSPLDIRKKLSGPLPPRLDENSAEPGPWEDPGTGWRWQGTPGPTPG
SDVDSVGGGSESRSLDSPTSSPGAGTRQLVKASSTGTESSDDFEERDPDLGDGLENGLGS
PFGKWTLSSAAQTHQLRRLRGPAKCRECEAFMVSGTECEECFLTCHKRCLETLLILCGHR
RLPARTPLFGVDFLQLPRDFPEEVPFVVTKCTAEIEHRALDVQGIYRVSGSRVRVERLCQ
AFENGRALVELSGNSPHDVSSVLKRFLQELTEPVIPFHLYDAFISLAKTLHADPGDDPGT
PSPSPEVIRSLKTLLVQLPDSNYNTLRHLVAHLFRVAARFMENKMSANNLGIVFGPTLLR
PPDGPRAASAIPVTCLLDSGHQAQLVEFLIVHYEQIFGMDELPQATEPPPQDSSPAPGPL
TTSSQPPPPHLDPDSQPPVLASDPGPDPQHHSTLEQHPTATPTEIPTPQSDQREDVAEDT
KDGGGEVSSQGPEDSLLGTQSRGHFSRQPVKYPRGGVRPVTHQLSSLALVASKLCEETPI
TSVPRGSLRGRGPSPAAASPEGSPLRRTPLPKHFEITQETARLLSKLDSEAVPRATCCPD
VQPEEAEDHL

  • Gold
  • Silver
  • Bronze
  • IntAct