Field Data
UniProt Accession: Q9P227
Gene Name: ARHGAP23
Gene Synonim: KIAA1501
GAP/GEF: GAP
Description: Rho GTPase-activating protein 23 (Rho-type GTPase-activating protein 23)
Keywords: Alternative splicing;Complete proteome;GTPase activation;Isopeptide bond;Phosphoprotein;Reference proteome;Ubl conjugation
Entrez ID: 57636
Ensembl Gene ID: ENSG00000273780
Ensembl Protein ID: ENSP00000488428
Our Specificity RhoA, Rac1
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol
GO:0070062extracellular exosome

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: focal_adhesions, plasma_membrane
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP23
atgaatggagtcgccttctgcctggtcgggatcccgccccgcccggagccccggccccca
cagctgccactgggcccaagagatgggtgctctcctaggcgccccttcccctggcagggg
ccgaggacgctgctgctgtacaaaagtccccaggacggctttggcttcactctgcgccac
ttcatcgtgtacccacccgagtcggccgtgcactgcagcctgaaggaggaagagaatgga
ggccgtggaggaggaccctccccccggtaccgcctggagcccatggacaccatctttgtc
aagaatgtgaaggaagacggccctgcccatagggcggggcttcgcacaggagaccggctg
gtaaaggtgaatggggaaagcgtcattgggaagacctactctcaggtcatagctctgatc
cagaatagtgatgacactctggagctgtctatcatgcccaaggacgaggacatcctccag
ctggcctactcccaggatgcctacctgaaagggaacgagccgtattctggagaggcccgc
agcatcccagagccaccgccgatctgctacccccgcaagacctacgcccctcctgcccgg
gcctccaccagggccactatggtgcctgagcccacctcagcactgcccagtgacccccgg
agtcctgctgcctggagtgacccggggctccgtgtgccacctgctgcccgtgcccacctg
gacaactcttccttggggatgagccagccccgccccagccctggtgccttcccccacctc
tcctcggagccccggacgccccgtgccttcccagagcctggcagccgggtgccccccagc
agactggagtgccagcaggccttgtcacactggctgtcaaaccaggtaccccgccgggcg
ggggagagacggtgcccagccatggccccccgggcccgcagcgcctcccaggaccggttg
gaggaggtggctgccccccgcccgtggccctgctccacctcccaggatgctttgagccag
ctgggccaggagggctggcaccgagctcgctcagatgactacttgagccgggccacccgt
tctgccgaggcactggggccaggggcactggtgtcaccccgctttgagcggtgtggctgg
gcttcccagcgttcgtctgcccgcacccccgcctgcccaactcgggacctgccagggccc
caggccccacccccgtctggcctgcagggcctggatgacctcgggtacatcggctaccgg
agctacagcccatcattccagcgccggaccggcctcctccatgcgctctccttccgggac
tcaccctttggggggctgcctaccttcaacctggcccagtcccctgcgtcattcccacca
gaggcctccgagccacccagggttgtacggccggaacccagcacccgggccctggagcct
cctgcggaggatcgcggcgatgaggtggtcctgaggcagaagcccccgacgggccgcaag
gttcagctgacccccgcaagacagatgaaccttggatttggtgacgagtccccagagcca
gaggccagtgggcgaggggaacgcctgggcaggaaggtggcccctttggccaccaccgaa
gactctctggcttccatcccctttattgatgagcccaccagccccagcattgacctccaa
gccaagcacgtccctgcctctgctgtggtctccagtgccatgaactcagcccctgtcctg
ggcaccagcccatcttccccgaccttcactttcaccctcggacgccattactcgcaggac
tgcagcagcatcaaggctggccgccgctcctcctacctgctggccatcaccacggagcgc
tccaagtcctgcgatgatggactcaacaccttccgcgacgagggccgggttctgcggcgc
ctgccaaaccgcatacccagcctgcggatgctccggagcttcttcaccgacgggtccttg
gatagctggggcacctctgaagatgctgacgctccttctaagcgacactcaacctctgac
ctctcagatgcgaccttcagcgatatcaggagagaaggctggttgtattataagcagatt
ctcaccaagaaggggaagaaagcgggcagcggcctgcgccagtggaagcgggtgtacgcc
gcgctgcgggcgcgctcgctctcgctgagcaaggagcggcgggagcccgggccggcggcg
gcgggggctgcggcggccggcgcaggtgaggacgaggcggcgcccgtctgcatcggctcc
tgcctcgtggacatctcctacagcgagaccaagaggaggcacgtgttccggctgaccacc
gctgacttctgtgaatatctctttcaggctgaggaccgggatgacatgctgggctggatc
agagcgatccgggagaacagcagggccgagggcgaggaccccggctgtgccaaccaagct
ctgatcagcaagaagcttaatgattatcgcaaagtgagccatagctctgggcccaaagct
gattcctcccccaaaggctctcgcggcctggggggcctcaagtctgagttcctcaagcag
agtgcggcacgtggcctcaggactcaggacctgcccgcagggagcaaggatgacagtgct
gcagcccccaaaaccccctggggcatcaacatcatcaagaaaaataagaaggccgctccg
agggcgtttggggtcaggctggaggagtgccagccagccacggagaaccagcgcgtcccc
ttaatcgtggctgcatgctgtcgcattgtggaggcacgagggctggagtccacaggcatt
taccgagtgcccggcaacaatgcagtggtgtccagcctacaggagcagctcaaccgcggg
cctggtgacatcaacctgcaggatgagcgctggcaagacctcaatgtgatcagcagcctg
ctcaagtccttcttccgaaagctgcccgagcctcttttcactgatgacaaatacaacgac
ttcatcgaggccaaccgcattgaggacgcgcgggagcgaatgaggacgctgcggaagctg
atccgggatctcccaggacactactatgaaacgctcaaattccttgtgggccatctcaag
accatcgctgaccactctgagaaaaacaagatggaaccccggaacctggccctggtcttt
gggccgacactggtgaggacgtctgaggacaacatgacagacatggtgacccacatgcct
gaccgctacaagatcgtggagacactgatccagcactcagactggttcttcagtgacgaa
gaggacaagggagagagaacccctgtgggcgacaaggagcctcatgcagtgcccaacatt
gagtacctcctgcccaacattggcaggacagtgccccctggcgacccggggtcagattct
accacctgtagttcagccaagtccaagggttcgtgggcccccaagaaggagccgtacgcc
cgggagatgctggcgatctccttcatctcggccgtcaaccgcaagcgcaagaagcggcgg
gaggcgcgggggctgggcagcagcaccgacgacgactcggagcaggaggcgcacaagcct
ggggcgggggccacagcgccggggactcaggagcggccgcaggggccgctgcctggcgcc
gtcgcccccgaggcccccggacgcctcagtcccccggcggcgccggaggagcggccggcc
gcggacacgcgctccattgtgtcgggctactccaccctgtccaccatggaccgcagcgtg
tgctcgggcgctagcggtcagcgggcaggggcgggggatgaggcggacgaccagcgtaac
gagctgagccacgtggagacggacactgaaggcgcggcgggcgcggggcctggggggcgc
ctgacacgccggccgtccttcagctcgcaccacctcatgccctgcgacactctggcacgc
cgccgcctggcccggggccgcccagacggcgagggcgcgggccggggcggtccccgcgcc
ccggagccgcccggctcggcgtcgtccagcagccaggagtcgctgcggcccccggcggcg
gcgctggcctcccggccctcgcgcatggaggcgctgcgtctaaggctccgcggcacggcg
gacgacatgctcgccgtgcgcctgcggcggccgctgtcgcccgagacccggcggcgccgg
agcagctggcgccgccacaccgtggtggtgcagagcccgctgactgacctcaacttcaac
gagtggaaggagctgggcggagggggccccccggagcctgcgggcgcgcgggcgcacagt
gacaacaaggactccggactcagcagcctggagtccaccaaggcgcgggccccgtcgtcc
gctgcctcgcagccgcccgcgcccggggacacggggtccctgcagagccagcccccgcgc
cgctcggccgcctcccgcctgcatcagtgtctgttaatta

Protein Sequence

>ARHGAP23
MNGVAFCLVGIPPRPEPRPPQLPLGPRDGCSPRRPFPWQGPRTLLLYKSPQDGFGFTLRH
FIVYPPESAVHCSLKEEENGGRGGGPSPRYRLEPMDTIFVKNVKEDGPAHRAGLRTGDRL
VKVNGESVIGKTYSQVIALIQNSDDTLELSIMPKDEDILQLAYSQDAYLKGNEPYSGEAR
SIPEPPPICYPRKTYAPPARASTRATMVPEPTSALPSDPRSPAAWSDPGLRVPPAARAHL
DNSSLGMSQPRPSPGAFPHLSSEPRTPRAFPEPGSRVPPSRLECQQALSHWLSNQVPRRA
GERRCPAMAPRARSASQDRLEEVAAPRPWPCSTSQDALSQLGQEGWHRARSDDYLSRATR
SAEALGPGALVSPRFERCGWASQRSSARTPACPTRDLPGPQAPPPSGLQGLDDLGYIGYR
SYSPSFQRRTGLLHALSFRDSPFGGLPTFNLAQSPASFPPEASEPPRVVRPEPSTRALEP
PAEDRGDEVVLRQKPPTGRKVQLTPARQMNLGFGDESPEPEASGRGERLGRKVAPLATTE
DSLASIPFIDEPTSPSIDLQAKHVPASAVVSSAMNSAPVLGTSPSSPTFTFTLGRHYSQD
CSSIKAGRRSSYLLAITTERSKSCDDGLNTFRDEGRVLRRLPNRIPSLRMLRSFFTDGSL
DSWGTSEDADAPSKRHSTSDLSDATFSDIRREGWLYYKQILTKKGKKAGSGLRQWKRVYA
ALRARSLSLSKERREPGPAAAGAAAAGAGEDEAAPVCIGSCLVDISYSETKRRHVFRLTT
ADFCEYLFQAEDRDDMLGWIRAIRENSRAEGEDPGCANQALISKKLNDYRKVSHSSGPKA
DSSPKGSRGLGGLKSEFLKQSAARGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAP
RAFGVRLEECQPATENQRVPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRG
PGDINLQDERWQDLNVISSLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKL
IRDLPGHYYETLKFLVGHLKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMP
DRYKIVETLIQHSDWFFSDEEDKGERTPVGDKEPHAVPNIEYLLPNIGRTVPPGDPGSDS
TTCSSAKSKGSWAPKKEPYAREMLAISFISAVNRKRKKRREARGLGSSTDDDSEQEAHKP
GAGATAPGTQERPQGPLPGAVAPEAPGRLSPPAAPEERPAADTRSIVSGYSTLSTMDRSV
CSGASGQRAGAGDEADDQRNELSHVETDTEGAAGAGPGGRLTRRPSFSSHHLMPCDTLAR
RRLARGRPDGEGAGRGGPRAPEPPGSASSSSQESLRPPAAALASRPSRMEALRLRLRGTA
DDMLAVRLRRPLSPETRRRRSSWRRHTVVVQSPLTDLNFNEWKELGGGGPPEPAGARAHS
DNKDSGLSSLESTKARAPSSAASQPPAPGDTGSLQSQPPRRSAASRLHQCLLI

  • Gold
  • Silver
  • Bronze
  • IntAct