Field Data
UniProt Accession: Q9P2F6
Gene Name: ARHGAP20
Gene Synonim: KIAA1391
GAP/GEF: GAP
Description: Rho GTPase-activating protein 20 (Rho-type GTPase-activating protein 20)
Keywords: 3D-structure;Alternative splicing;Chromosomal rearrangement;Complete proteome;GTPase activation;Phosphoprotein;Polymorphism;Reference proteome;Tumor suppressor
Entrez ID: 57569
Ensembl Gene ID: ENSG00000137727
Ensembl Protein ID: ENSP00000436522
Our Specificity Cdc42, RhoA, Rac1
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005829cytosol

Molecular Function

GO ID Description
GO:0005096GTPase activator activity

Biological Process

GO ID Description
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: plasma_membrane
Localization in the literature: plasma membrane

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP20
atggaagcgatgtccccccagcaggagactctagggggacagccggggcgctcctcttcc
ctgacaggagtgtctcggctcgcgggaggcagctgcaccaagaagaaaatgaaaacacta
gcagaaaggaggaggagcgctccatctcttatcctggataaagccctacaaaaacggcct
actaccagggacagtccttctgctagtgttgacacatgcacatttctgtcatcattagtg
tgctccaataggactctgctgattgatggccgggcagaactcaaaagaggcctccagagg
caggagcggcatcttttcctattcaatgatctgtttgttgtggccaaaatcaaatataac
aataactttaagataaaaaataaaattaaattaactgatatgtggacagcaagctgtgtg
gatgaagtgggagaaggcaacaccaatgccatgaaatcctttgttttgggctggcccaca
gtgaactttgtggccactttcagttctccagaacaaaaggacaaatggctctctctcctt
cagagatacatcaatctagagaaagaaaaggactacccgaagagcattcccctcaaaatc
ttcgccaaggacattgggaattgtgcctactctaaaactataacagtaatgaattcagat
acagcgaatgaagttatcaacatgtcattaccaatgctagggataactggctctgagaga
gattaccagttgtgggtcaattctggcaaagaagaggctccatacccactcattgggcat
gaatatccatatggaattaaaatgagccatcttcgagactctgcactcctgacaccggga
tcaaaggactctaccacccctttcaacctccaggagcccttccttatggaacagctcccc
cgagagatgcagtgccagttcatcctgaagcccagccgcctggctgcagcccagcaactg
agtgattcaggtcataagacatttaaaaggagaagatctatcataaactgggccttctgg
cgaggttctagcactcacctggacaacttgccctcatcgccaacatcacctatgccagga
cagctctttggaatttctctgccaaatatttgtgagaatgacaatctgcccaaacctgtc
ttggatatgcttttctttcttaatcaaaaaggacctctcaccaaaggtatcttcaggcaa
tcagccaatgtgaaatcctgcagagaactaaaagagaaattgaattctggagtcgaagta
cacctagactgtgaatctatttttgtgatagcatctgtcttaaaggattttctgcgaaat
attccaggaagtattttttcatcagatctctatgatcactgggtctctgtaatggatcaa
ggaaatgatgaagagaaaataaatactgttcaaaggctattagaccagcttccgagagcc
aatgttgttctcctaaggtatctttttggggtgttacacaacattgagcaacattcctca
tccaatcagatgactgcatttaatttagctgtgtgtgtcgctccaagtattctttggcct
cctgcttcctccagcccagaactagaaaacgaatttacaaaaaaggtttccctgcttata
caatttctgattgagaattgccttaggatatttggagaagaaatcacttccctcttcaga
gaggtttcagtgagatgtgacactagagagaatgcctcagatatttcttgctttcaactg
aatgactcctcctatgacagcttggaaaatgagctaaatgaggatgttgatgcaccatgc
agtgacttggtaaagaaacttggccaggggagcagaagcatggactctgtcttaaccctc
agtgactatgatcttgaccagcccgaggtggaaggccttttaaccctaagcgactttgac
ttggcccattctaaagatgaagatgttcaaatgaaacggcctcttgaatccaagccggtg
aacattttagtgtacacaaagatcccactgcgggatcatgccagggccccatctgccatg
tgcacacccagctacctgtccacagctgcagcaaatgctgcaaaaagcctgaggcgacac
cggcgttgctcagagcccagcatcgactatctggattcaaagctttcctacctcagggag
ttttatcagaaaaagctacgcaagtccagctgtgatgcaattctttctcaaaaagatgaa
gactatctgaagcagaatcaacccctccaggaggaaggaaagacatgttttaaacagagt
ttagtcacaggcactgatgtcagcaagaaaaatgccactactcaaaacactaagaagaaa
agcttgtctggtagtgaaggaaatcacgtgaaacttttccctaagtctaagccagtggcc
atttctgtggcatcttatagtcctatgtcctcacaggatcattccaagaaccagcccttt
gatgtgaatacatctggatactccccaccacacacagcagatgccctcaagggtccaagg
acacatcggcgctgctcagagcccaacatagaagaccagaaccgcaagctgacctatctc
aggggaatttattcaaagaaacaacataaaaccagctgtgaagctggtctcttgcatgga
gaggaggattatctcaaacggcataagtctttgcaaatggaggggcagaagctcattaat
cagagtttagtcatggggattgaggtgggcaagagtagtgccacaaaccaaaacactgag
aaggttttacccccaagattaaacctttgcccaaggaccagctattccagcttatcctcc
ccaggcacttccccatccggctcatcagtaagctcccaagacagtgctttttctcagatt
tctgaacactctgtgtttacacccactgagacttcctctccaatagattgcacttttcag
gctcagagaaaacgggaagacctttctcctgactttagcaatgccagccatgtttccgga
atgcccggtccctcatcagggcaggcttgcagccgcccagcctatacaaagaaggacacc
atggagtggcattcacaaatgcattctgtaactcttcatcccagcacatggttgagaaat
ggtgtggccagtttgaaaaactggtccctcaaaaagaaagcaaaggcagccagaccagag
gaagagaaaatagcttctccaaaaggacccttagagccacccccacatgcttctggtgtt
ccagaagccaactcactgcaagaggaacaaaaagacttgcccttaagggcagctgaagga
ctgtcccctgtgcagtcagcccaaaggtgtagttcttctcccttccaggactcagagaga
cactgtagctctccattcagcctggtggagagcagacttaagctgtgcatgaagtcacat
gaggaaatagagcctggtagtcagagctcttctggttctctgccttgggaaagagcctca
gccagctcttggactctagaggatgcgaccagcccagactcagggcctacagtggtctgc
gacattgaggacaggtatttaaccaaagacattttaatta

Protein Sequence

>ARHGAP20
MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRP
TTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYN
NNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLL
QRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSER
DYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLP
REMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPG
QLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEV
HLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRA
NVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLI
QFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPC
SDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPV
NILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLRE
FYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKK
SLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPR
THRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLIN
QSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQI
SEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDT
MEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGV
PEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSH
EEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDILI

  • Gold
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  • Bronze
  • IntAct