Field Data
UniProt Accession: Q9ULL1
Gene Name: PLEKHG1
Gene Synonim: KIAA1209
GAP/GEF: GEF
Description: Pleckstrin homology domain-containing family G member 1
Keywords: Complete proteome;Guanine-nucleotide releasing factor;Phosphoprotein;Polymorphism;Reference proteome
Entrez ID: 57480
Ensembl Gene ID: ENSG00000120278
Ensembl Protein ID: ENSP00000351318
Our Specificity Cdc42
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005654nucleoplasm
GO:0005634nucleus

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0035023regulation of Rho protein signal transduction

Reactome

KEGG

Field Data
Localization in this study: actin, focal_adhesions
Localization in the literature:

Confocal Images

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Cytochalasin D Screen Positive

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TIRF

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>PLEKHG1
atggagctctctgatagtgaccgacccgtcagcttcggttccacatcatcctcggcctct
tcccgcgacagccatggttccttcggcagcagaatgaccttagtttcaaatagccacatg
ggcttgtttaaccaggataaggaggtaggggccataaaactggagctgattcctgccagg
ccgttttccagcagcgagctgcagagggacaaccccgccacggggcaacagaacgcggat
gagggcagcgaaaggccacccagagcgcagtggagagtggactcaaacggggcacccaag
acgatcgcagactcggccacgagccccaagctcctctatgtggatagagttgttcaggaa
attctggaaaccgaaaggacttatgtacaagatttaaaaagcatcgtagaggattacctt
gactgcatcagggaccaaacaaaacttcccctggggaccgaagaaagatcagcccttttt
ggaaacatacaggatatctaccacttcaatagtgaacttctgcaagatttggaaaactgt
gaaaatgatcctgtggccatagcagagtgttttgtgtccaagagtgaagagttccacatt
tatacccagtattgcactaactatccaaggtccgtggctgtgctaacagagtgtatgagg
aacaagatactggccaaattcttcagggaacgtcaggaaactctgaaacactcgctgcct
ctggggtcctatctcttgaaaccagttcagcggattctcaagtatcatctccttctgcat
gaaatagaaaaccaccttgataaggacacagaaggctatgatgtggtgcttgatgctata
gacacaatgcagcgagtcgcctggcatatcaatgacatgaagcggaaacacgagcacgcg
gtccggttacaggagatacagagtttgctcactaactggaaggggccagacctgaccagc
tacggggaactggtgcttgagggaaccttccgcatccagcgagccaagaatgagcggacg
ctcttcctcttcgacaagctgctgctcatcacgaagaagagagatgacacgtttacatac
aaagctcacatcctgtgtggcaacctcatgcttgtggaggtgattccaaaagagccgctc
agcttcagcgtcttccactacaagaatcccaagctgcagcacacagtccaggccaaatcc
cagcaagacaaacgcctctgggttctgcacctaaagagactgattctggagaaccatgca
gccaagattccagctaaggccaagcaagcaatccttgaaatggatgccattcatcatcca
ggcttctgttacagtcctgagggagggacgaaagcactgttcggctctaaagaaggttct
gctccatatcggctgagaagaaaatctgaaccttcctcacggtcacataaagttttgaag
accagtgaaacagcacaagacatccaaaaggtttctagagaggaaggatctccccagctg
tcttcagcaaggccgtctcctgcccagagaaatagtcagcctagcagttctaccatgatc
agcgtgcttcgagcgggtggagctctcagaaacatctggaccgatcaccagatcaggcaa
gccttgtttcccagccgacggtccccgcaggagaatgaggatgatgaagatgattatcag
atgttcgtgccgtcattttcctcctcagatctgaactctaccagactatgtgaagatagc
acttctagtcgcccttgcagctggcatatgggacagatggagtccacagagacctccagc
tctggtcacaggattgtcaggcgggccagcagtgctggggagagcaacacatgccctcct
gaaataggaactagtgacagaactagggaactgcagaacagccccaaaacagaagggcag
gaggagatgactccctttgggtcatccatagagttgactattgatgacatagaccatgtc
tatgataacatcagttatgaggacttaaaactaatggttgctaagcgggaagaagctgaa
tccactccctctaaatcagccagggactccgttcgccccaagagcaccccagagttagcc
ttcacaaagaggcaagctggccacagtaagggctctctttacgcacaaacagatggcacc
ctctcaggtggagaggcatccagccaaagcacgcatgaactccaagcggttgaggagaac
atctatgacaccatagggctcccagatcctccgtcgctgggttttaagtgcagcagccta
aagcgtgcaaagcggagcacctttttgggtctggaggccgacttcgtgtgctgtgacagc
ctgaggccatttgtttcccaagacagcctccagctcagtgaggacgaagccccttaccat
caggccacccccgatcatggttatctgagtttgctgtatgactctcccagtggtaacttg
tctatgcctcataagcctgtatctgataaactgtccgaagaagtagatgaaatctggaat
gacctggaaaattacatcaagaaaaatgaagacaaggccagagaccgtctcctggcagcg
tttcctgtgagcaaggatgatgtgccagacaggctgcacgcagagagcacccctgagctg
agccgggacgtggggcgctctgtgtccacgctgtccctgcctgagagccaggctctcctc
acgcccgtgaagagcagggctggcagagccagccgcgccaactgcccctttgaggaagac
ctgatttctaaagaaggctcctttatgagccttaaccggctttctctggctagtgaaatg
cccctcatggacaatccctacgacctggccaacagtggcctgtctcaaacagacccagaa
aaccctgacctggggatggaggccacagataagacaaaaagcagggtgtttatgatggct
cggcagtacagtcagaagattaagaaggcgaatcaacttttaaaagtgaaaagtctggag
ctggagcagccgccggccagtcagcatcagaaatccatgcacaaagacctggctgccatc
ttggaagagaagaagcaaggagggcccgccattggtgccaggattgctgagtattcccag
ttgtatgaccagattgtattcagagagtctcccttgaaaattcagaaggatggctgggcc
agccctcaagaatcctccctcctgaggtctgtgtcaccttcccaggtccaccatggtagt
ggagactggcttctgcattcaacctatagtaatggagagttagcagatttctgtctccca
ccagagcaagacttgaggtcaagatatcccacgtttgagatcaatacaaaaagtactccc
aggcaattgtccgcagcttgctctgtgccttctcttcaaacctctgaccctctgccaggc
tctgtgcagagatgcagcgtggtagtaagtcagcccaacaaagagaactggtgtcaggac
catctttacaactccttgggtcggaaagggatcagcgctaaatctcagccttatcacagg
tcccagtcatcttcctccgtcttgatcaacaaatcaatggattccatcaactaccctagt
gatgtgggaaagcagcagctgctgtctttacacagaagttcaaggtgtgagagtcaccag
gacttgctgccagatattgctgactcgcatcaacagggcactgaaaaactctcagatctc
acactccaagactcacagaaagttgtggtggtcaatagaaatttacccttaaatgcccaa
attgcaacacagaattatttttccaatttcaaagagactgatggagatgaagatgactat
gtggaaatcaagtcagaagaagatgagtcggagttggagctatctcacaatcgtagaagg
aaatctgactcaaagtttgtggatgctgacttttctgataatgtctgcagcggcaacaca
ttgcattctttgaatagtccgcgcactccaaaaaagccggttaacagcaaacttggcctt
tcaccatatctgacaccatataatgattctgacaaactgaatgactatctttggaggggg
ccatctcccaatcaacaaaatattgtccagtctctaagggaaaaatttcagtgtctcagt
tcaagcagctttgctt

Protein Sequence

>PLEKHG1
MELSDSDRPVSFGSTSSSASSRDSHGSFGSRMTLVSNSHMGLFNQDKEVGAIKLELIPAR
PFSSSELQRDNPATGQQNADEGSERPPRAQWRVDSNGAPKTIADSATSPKLLYVDRVVQE
ILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLENC
ENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQETLKHSLP
LGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDMKRKHEHA
VRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQRAKNERTLFLFDKLLLITKKRDDTFTY
KAHILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQDKRLWVLHLKRLILENHA
AKIPAKAKQAILEMDAIHHPGFCYSPEGGTKALFGSKEGSAPYRLRRKSEPSSRSHKVLK
TSETAQDIQKVSREEGSPQLSSARPSPAQRNSQPSSSTMISVLRAGGALRNIWTDHQIRQ
ALFPSRRSPQENEDDEDDYQMFVPSFSSSDLNSTRLCEDSTSSRPCSWHMGQMESTETSS
SGHRIVRRASSAGESNTCPPEIGTSDRTRELQNSPKTEGQEEMTPFGSSIELTIDDIDHV
YDNISYEDLKLMVAKREEAESTPSKSARDSVRPKSTPELAFTKRQAGHSKGSLYAQTDGT
LSGGEASSQSTHELQAVEENIYDTIGLPDPPSLGFKCSSLKRAKRSTFLGLEADFVCCDS
LRPFVSQDSLQLSEDEAPYHQATPDHGYLSLLYDSPSGNLSMPHKPVSDKLSEEVDEIWN
DLENYIKKNEDKARDRLLAAFPVSKDDVPDRLHAESTPELSRDVGRSVSTLSLPESQALL
TPVKSRAGRASRANCPFEEDLISKEGSFMSLNRLSLASEMPLMDNPYDLANSGLSQTDPE
NPDLGMEATDKTKSRVFMMARQYSQKIKKANQLLKVKSLELEQPPASQHQKSMHKDLAAI
LEEKKQGGPAIGARIAEYSQLYDQIVFRESPLKIQKDGWASPQESSLLRSVSPSQVHHGS
GDWLLHSTYSNGELADFCLPPEQDLRSRYPTFEINTKSTPRQLSAACSVPSLQTSDPLPG
SVQRCSVVVSQPNKENWCQDHLYNSLGRKGISAKSQPYHRSQSSSSVLINKSMDSINYPS
DVGKQQLLSLHRSSRCESHQDLLPDIADSHQQGTEKLSDLTLQDSQKVVVVNRNLPLNAQ
IATQNYFSNFKETDGDEDDYVEIKSEEDESELELSHNRRRKSDSKFVDADFSDNVCSGNT
LHSLNSPRTPKKPVNSKLGLSPYLTPYNDSDKLNDYLWRGPSPNQQNIVQSLREKFQCLS
SSSFA

  • Gold
  • Silver
  • Bronze
  • IntAct