Field Data
UniProt Accession: Q9UNA1
Gene Name: ARHGAP26
Gene Synonim: GRAF, KIAA0621, OPHN1L
GAP/GEF: GAP
Description: Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26)
Keywords: 3D-structure;Alternative splicing;Cell junction;Chromosomal rearrangement;Complete proteome;Cytoplasm;Cytoskeleton;Disease mutation;GTPase activation;Proto-oncogene;Reference proteome;SH3 domain
Entrez ID: 23092
Ensembl Gene ID: ENSG00000145819
Ensembl Protein ID: ENSP00000367243
Our Specificity RhoA
Literature Specificity RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0005829cytosol
GO:0005575cellular_component
GO:0005925focal adhesion
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005543phospholipid binding
GO:0005096GTPase activator activity
GO:0005515protein binding

Biological Process

GO ID Description
GO:0030036actin cytoskeleton organization
GO:0051056regulation of small GTPase mediated signal transduction
GO:0007165signal transduction
GO:0007399nervous system development
GO:0043547positive regulation of GTPase activity

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: endoplasmic_reticulum
Localization in the literature: lipid droplets focal adhesions focal adhesions, actin

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>ARHGAP26
atggggctcccagcgctcgagttcagcgactgctgcctcgatagtccgcacttccgagag
acgctcaagtcgcacgaagcagagctggacaagaccaacaaattcatcaaggagctcatc
aaggacgggaagtcactcataagcgcgctcaagaatttgtcttcagcgaagcggaagttt
gcagattccttaaatgaatttaaatttcagtgcataggagatgcagaaacagatgatgag
atgtgtatagcaagatctttgcaggagtttgccactgtcctcaggaatcttgaagatgaa
cggatacggatgattgagaatgccagcgaggtgctcatcactcccttggagaagtttcga
aaggaacagatcggggctgccaaggaagccaaaaagaagtatgacaaagagacagaaaag
tattgtggcatcttagaaaaacacttgaatttgtcttccaaaaagaaagaatctcagctt
caggaggcagacagccaagtggacctggtccggcagcatttctatgaagtatccctggaa
tatgtcttcaaggtgcaggaagtccaagagagaaagatgtttgagtttgtggagcctctg
ctggccttcctgcaaggactcttcactttctatcaccatggttacgaactggccaaggat
ttcggggacttcaagacacagttaaccattagcatacagaacacaagaaatcgctttgaa
ggcactagatcagaagtggaatcactgatgaaaaagatgaaggagaatccccttgagcac
aagaccatcagtccctacaccatggagggatacctctacgtgcaggagaaacgtcacttt
ggaacttcttgggtgaagcactactgtacatatcaacgggattccaaacaaatcaccatg
gtaccatttgaccaaaagtcaggaggaaaagggggagaagatgaatcagttatcctcaaa
tcctgcacacggcggaaaacagactccattgagaagaggttttgctttgatgtggaagca
gtagacaggccaggggttatcaccatgcaagctttgtcggaagaggaccggaggctctgg
atggaagccatggatggccgggaacctgtctacaactcgaacaaagacagccagagtgaa
gggactgcgcagttggacagcattggcttcagcataatcaggaaatgcatccatgctgtg
gaaaccagagggatcaacgagcaagggctgtatcgaattgtgggtgtcaactccagagtg
cagaagttgctgagtgtcctgatggaccccaagactgcttctgagacagaaacagatatc
tgtgctgaatgggagataaagaccatcactagtgctctgaagacctacctaagaatgctt
ccaggaccactcatgatgtaccagtttcaaagaagtttcatcaaagcagcaaaactggag
aaccaggagtctcgggtctctgaaatccacagccttgttcatcggctcccagagaaaaat
cggcagatgttacagctgctcatgaaccacttggcaaatgttgctaacaaccacaagcag
aatttgatgacggtggcaaaccttggtgtggtgtttggacccactctgctgaggcctcag
gaagaaacagtagcagccatcatggacatcaaatttcagaacattgtcattgagatccta
atagaaaaccacgaaaagatatttaacaccgtgcccgatatgcctctcaccaatgcccag
ctgcacctgtctcggaagaagagcagtgactccaagcccccgtcctgcagcgagaggccc
ctgacgctcttccacaccgttcagtcaacagagaaacaggaacaaaggaacagcatcatc
aactccagtttggaatctgtctcatcaaatccaaacagcatccttaattccagcagcagc
ttacagcccaacatgaactccagtgacccagacctggctgtggtcaaacccacccggccc
aactcactccccccgaatccaagcccaacttcacccctctcgccatcttggcccatgttc
tcggcgccatccagccctatgcccacctcatccacgtccagcgactcatcccccgtcagg
tctgttgcagggtttgtttggttttctgttgctgccgttgttctctcattggctcggtcc
tctcttcatgcagtgttcagcctcctcgtcaactttgttccctgccatccaaacctgcac
ttgctttttgacaggccagaagaagcggtacatgaagactccagcacaccgttccggaag
gcaaaagccttgtatgcctgcaaagctgaacatgactcagaactttcgttcacagcaggc
acggtcttcgataatgttcacccatctcaggagcctggctggttggaggggactctgaac
ggaaagactggcctcatccctgagaattacgtggagttcctcttaatta

Protein Sequence

>ARHGAP26
MGLPALEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKF
ADSLNEFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFR
KEQIGAAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLE
YVFKVQEVQERKMFEFVEPLLAFLQGLFTFYHHGYELAKDFGDFKTQLTISIQNTRNRFE
GTRSEVESLMKKMKENPLEHKTISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSKQITM
VPFDQKSGGKGGEDESVILKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALSEEDRRLW
MEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRIVGVNSRV
QKLLSVLMDPKTASETETDICAEWEIKTITSALKTYLRMLPGPLMMYQFQRSFIKAAKLE
NQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHKQNLMTVANLGVVFGPTLLRPQ
EETVAAIMDIKFQNIVIEILIENHEKIFNTVPDMPLTNAQLHLSRKKSSDSKPPSCSERP
LTLFHTVQSTEKQEQRNSIINSSLESVSSNPNSILNSSSSLQPNMNSSDPDLAVVKPTRP
NSLPPNPSPTSPLSPSWPMFSAPSSPMPTSSTSSDSSPVRSVAGFVWFSVAAVVLSLARS
SLHAVFSLLVNFVPCHPNLHLLFDRPEEAVHEDSSTPFRKAKALYACKAEHDSELSFTAG
TVFDNVHPSQEPGWLEGTLNGKTGLIPENYVEFLLI

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  • IntAct