Field Data
UniProt Accession: Q9Y3L3
Gene Name: SH3BP1
Gene Synonim:
GAP/GEF: GAP
Description: SH3 domain-binding protein 1
Keywords: 3D-structure;Alternative initiation;Alternative splicing;Cell junction;Cell projection;Complete proteome;Cytoplasm;GTPase activation;Nucleus;Phagocytosis;Phosphoprotein;Polymorphism;Reference proteome;SH3-binding;Tight junction
Entrez ID: 23616
Ensembl Gene ID: ENSG00000100092
Ensembl Protein ID: ENSP00000411979
Our Specificity Rac1
Literature Specificity Cdc42, Rac1
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005829cytosol
GO:0030027lamellipodium
GO:0005634nucleus
GO:0031252cell leading edge
GO:0005912adherens junction
GO:0005923bicellular tight junction
GO:0001891phagocytic cup

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0017124SH3 domain binding
GO:0005515protein binding
GO:0030215semaphorin receptor binding

Biological Process

GO ID Description
GO:0007015actin filament organization
GO:0045198establishment of epithelial cell apical/basal polarity
GO:0030834regulation of actin filament depolymerization
GO:0043547positive regulation of GTPase activity
GO:0071526semaphorin-plexin signaling pathway
GO:0006911phagocytosis, engulfment
GO:0046847filopodium assembly
GO:0043535regulation of blood vessel endothelial cell migration
GO:0007165signal transduction
GO:0032956regulation of actin cytoskeleton organization
GO:0051058negative regulation of small GTPase mediated signal transduction
GO:0016477cell migration
GO:0034329cell junction assembly

Reactome

KEGG

Field Data
Localization in this study: actin
Localization in the literature: vesicles plasma membrane (junctions)

Confocal Images

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Cytochalasin D Screen Positive

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>SH3BP1
atgatgaagaggcagctgcaccgcatgcggcagctggcccagacgggcagcttgggacgc
accccggagaccgctgagttcctgggtgaggacctgctgcaggtagaacagcggctggag
ccggccaagcgggcagcccacaacatccacaagcggctgcaggcctgtctgcagggccag
agcggggcagacatggacaagcgggtgaagaagcttcccctcatggctctgtccaccacg
atggctgagagcttcaaggagctggaccctgattccagcatggggaaggccttggagatg
agctgtgccatccagaatcagctggcccgcatcctggccgagtttgagatgaccctggag
agggacgtcctgcagccactcagcaggctgagtgaggaggagctgccagccatcctcaaa
cacaagaaaagcctccagaagctcgtgtccgactggaacacactcaagagcaggctcagt
caggcaaccaagaattcaggcagcagtcaaggcctaggaggcagcccgggtagtcacagc
catacgaccatggccaacaaggtggagacgctgaaggaggaggaggaggagctgaagagg
aaagtggagcaatgcagggacgagtacttggctgacctgtaccactttgttaccaaggag
gactcctatgccaactacttcattcgtctcctggagattcaggccgattaccatcgcagg
tcactgagctcgctggacacagccctggctgagctgagggagaaccacggccaagcagac
cactccccttcgatgacagccacccacttccccagggtgtatggggtgtcgctggcaacc
cacctgcaagagctgggccgggagattgccctgcccatcgaggcctgcgtcatgatgctg
ctttctgagggcatgaaggaagagggtctcttccgtctggctgctggggcctcggtgctg
aagcgtctcaagcagacaatggcctcggacccccacagcctggaggagttctgctccgac
ccgcacgctgtggcaggtgccctcaagtcctatctgcgggagctgccagagcctctgatg
accttcgacctctatgatgactggatgagggcagccagcctgaaggagccaggggcccgg
ctgcaggccctccaagaggtgtgcagccgcctaccccccgagaacctcagcaacctcagg
tacctgatgaagttcctggcacggctggccgaggagcaggaggtgaacaagatgacaccc
agcaacatcgccatagtcctgggacccaacttgctgtggccacctgagaaagaaggggac
caggcccagctggatgcagcctccgtgtcttccatccaggtggtgggcgtcgtcgaggcg
ctgatccagagcgcagacaccctcttccctggagacatcaacttcaacgtgtcaggcctc
ttctcagctgttaccctccaggacacagtcagtgacaggctggcctctgaggaacttccg
tccactgccgtgcccaccccagccaccaccccggctccggctccggctccagctccagct
ccggccccagccttggcttcagcagctaccaaggaaaggacagagtctgaggtgcctccc
agaccagcctcccccaaggtcaccaggagtcccccggagacagctgccccagtggaggac
atggctcggaggaccaagcgcccggcgccagcccggcccaccatgccgcccccccaggtc
tccggctcccgctcctcccctccagccccgcccttgccccctggctctggcagccctggg
accccccaagccctgccccgacgtctggttggcagcagcctccgagcccccacagtgcca
cccccgttaccccccacaccccctcagcctgcccggcgccaaagccggcgttcaccagcc
tcccccagcccggcctccccaggtccagcctcccccagcccagtctctttgagtaaccct
gcacaggtggacctgggggctgccacagcagagggaggagcccctgaggctatcagtggg
gtccccactcccccagctatccccccgcagccccgccccaggagccttgcctcagagacc
aact

Protein Sequence

>SH3BP1
MMKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQ
SGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLE
RDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHS
HTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRR
SLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMML
LSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLM
TFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTP
SNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGL
FSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPP
RPASPKVTRSPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPG
TPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNP
AQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN

  • Gold
  • Silver
  • Bronze
  • IntAct