Field Data
UniProt Accession: Q9Y3M8
Gene Name: STARD13
Gene Synonim: DLC2, GT650
GAP/GEF: GAP
Description: StAR-related lipid transfer protein 13 (46H23.2) (Deleted in liver cancer 2 protein) (DLC-2) (Rho GTPase-activating protein) (START domain-containing protein 13) (StARD13)
Keywords: 3D-structure;Acetylation;Alternative splicing;Complete proteome;Cytoplasm;GTPase activation;Lipid droplet;Membrane;Mitochondrion;Phosphoprotein;Polymorphism;Reference proteome;Tumor suppressor
Entrez ID: 90627
Ensembl Gene ID: ENSG00000133121
Ensembl Protein ID: ENSP00000382300
Our Specificity RhoA
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005811lipid droplet
GO:0005829cytosol
GO:0016020membrane
GO:0005739mitochondrion
GO:0031966mitochondrial membrane

Molecular Function

GO ID Description
GO:0005096GTPase activator activity
GO:0008289lipid binding
GO:0005515protein binding

Biological Process

GO ID Description
GO:0043542endothelial cell migration
GO:0051056regulation of small GTPase mediated signal transduction
GO:0043547positive regulation of GTPase activity
GO:0090051negative regulation of cell migration involved in sprouting angiogenesis
GO:0007165signal transduction
GO:0097498endothelial tube lumen extension

Reactome

Reactome ID Description
R-HSA-194840Rho GTPase cycle

KEGG

Field Data
Localization in this study: focal_adhesions
Localization in the literature: focal adhesions mitochondria

Confocal Images

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Cytochalasin D Screen Negative

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TIRF

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organism orgs
Organism: Mus musculus

Nucleotide Sequence

>STARD13
atgttcagccaggtgcccaggacgccggctgcaggctgctactatctaaaccccttgaca
cctgagagccaggagatgtacttgcgatttgatcagactgccagacgctctccctacagg
atgagccggatcctagcacgccatcacctagtgactaaaatccagcaagaaattgaggcg
aaggaagcatgtgactggctccgagctgccgggttcccgcagtacgctcagctgtatgaa
gattcgcagttccccatcaacattgcggccgtcaaaaaagaccatgactttcttgaaagg
gaccttgtagaacctctttgcagacgacttaatacgttgaacaagtgtgcctcaatgaga
cttgatgtgaacttccaaaggaaaaagggtgacgactcagatgaggaagacctgtgcatc
agcaacaaatggactttccagagaaccagccgcagatggtcccgtgtggatgacctgcat
acgctgttccccgtggcagacagaaacgggtccccaggaggccctaggatgagaaacaca
gccagcagtgagagcgtgctcacggatctgagtgagccagaggtctgctctattcacagc
gaaagcagtgggggcagtgacagccgcagccaatcagggcatcattctgctgacagtacg
catgcgctggaggccaccctggtcagtagcagcctcccacagtctacccgagagggtctc
aaccagtcttttcaccccaagaatgagaaacccaccaggaccagggccaagtcctttctg
aaacgcatggataccctgagagtgaagggtgcacttgggaggcataaggggccagggcgg
acaggaggcctggtcatcagtaggcctgtgctgcagcaggaaccggagtcctttaagacc
atgcagtgcgtccagatacccaacggagatctgcagacctcacctccagctgcctgcagg
aaaggcctcccatgctccagtaagtcaagtggtgagagcagccccctggagaacagcagc
acagtgagcactccgtgcatgaaggaacgcaagtgccaccacgaggccaacaagcgcggt
ggcatgtacctggaggacctggatgtgctggcagggacggcattaccagatacgtcagac
caaaaccacgtgcatgggtttcactcccaagaaaacttggtggtccacattcccaaggat
cacaaaccaggaacgttccccaaggcactttctatagaaagcctctcacccacagacaac
agcaatggggttaactggaggaccgggagtatctccctgggtaggcaacagggccctggc
atgagggaacccagactcatgtcttcctgccacagggccagccgtgtcagtatctatgac
aatgtccccagctcgcacctgtatgccagcacaggagatctgttggacctggagaaagac
ggcctccttccacagctggatgacatcctacagcatgtcaatggcatacaagaggtagtg
gatgactggtcaaaaaacatcttacccgaactgcaaagtcacagcacattggcaggggat
cctggtctgtccccattcccatctcccaatcaggtcactttagattttgaaggcaactct
gtctcagaaggtcggacaacacctagtgatgtggaaagggacaggacttctctgaatgaa
tcggaggccactggggtcagagaaagaagggattctggtgtgggggcctctctgaccaga
ccaaacagacgactaaggtggagcagcttccagctctcacaccagccccagccgtctcca
gccaccccgcacatcagcagccagacggccgcccagctgaacctgctccagcgcttctcc
ctacttcgtcttacggccatcatggagaagtactctatgtccaacaagcacggctggacc
tggtccgttccaaagttcatgaagaggatcaaagctcctgactaccgagacaaggctgtc
ttcggtgttccgctcatagtccacgttcagagaacaggacagcccctgcctcagagcatc
caacaagcactgaggtatctacgtagcaactgtctggatcaggtgggtcttttccgcaag
tcaggagtgaagtctcgaatccatgccctccgtcagatgaatgagaacttccctgacaat
gtgagctatgaagaccagtctgcatacgacgtggcagatatggtgaagcagttcttccgg
gacctccctgagcccctgttcaccaacaagctcagcgagaccttcctccacatctatcag
tatgtccccaaagagcagcggctgcaggccgtgcaggcagccatcctgctgctggccgac
gagaaccgggaggtcctgcagactctcctgtgcttcctgcatgacgtagtaaacttggtg
gacgagaatcagatgacgcccatgaatctggccgtgtgcctggccccctccctctttcac
ctaaacttactgaagaaagaaagctccccaaaagtcatccagaagaaatacgccactggg
aagccagatcagaaggacctcaatgaaaatctagctgcggctcaggggctggcccacatg
atcacggaatgcaaccgactctttgaggttccacacgagatggtggcccagtctcgggac
tcctacttagaggctgaaatccatgtgcccagcctggaagacttgggagcacagctggcg
gagagcggggcaacttttcacacgtacttggagcatctagtccaaggcctccagaaagag
gctaaggagaaattcaagggatgggtcacatgttccagccctgacaacacagaccttgct
ttcaaaaaggtgggcgatgggcacccgctgaagctgtggaaagcatctgtggaggtggag
gcaccaccctccgtggtgctgaaccgtgtgctgagagaacgtcacctgtgggatgaggac
tttgtgcagtggaaggtggtggaaagattggacaaacaaacggaaatctaccagtacgtg
ctaaacagcatggttccacatccctccagagacttcctggtgctcaggacctggaagact
gacctgcccaaaggaatgtgcaccctggtgtccctgtctgtggagtacgaagaagcccag
ctcatgggtggcgtgagggcggtggtgatggactctcagtacctgatagaaccctgcggt
tctggcaagtccaggctgacccacatctgcagaatagacctgaagggccactccccagaa
tggtacagcaaaggctttggacacctctgtgcggcagaagttaccagaattaggaactct
ttccagcctctcgttgctgagggtccagaaacaaaaatcttaatta

Protein Sequence

>STARD13
MFSQVPRTPAAGCYYLNPLTPESQEMYLRFDQTARRSPYRMSRILARHHLVTKIQQEIEA
KEACDWLRAAGFPQYAQLYEDSQFPINIAAVKKDHDFLERDLVEPLCRRLNTLNKCASMR
LDVNFQRKKGDDSDEEDLCISNKWTFQRTSRRWSRVDDLHTLFPVADRNGSPGGPRMRNT
ASSESVLTDLSEPEVCSIHSESSGGSDSRSQSGHHSADSTHALEATLVSSSLPQSTREGL
NQSFHPKNEKPTRTRAKSFLKRMDTLRVKGALGRHKGPGRTGGLVISRPVLQQEPESFKT
MQCVQIPNGDLQTSPPAACRKGLPCSSKSSGESSPLENSSTVSTPCMKERKCHHEANKRG
GMYLEDLDVLAGTALPDTSDQNHVHGFHSQENLVVHIPKDHKPGTFPKALSIESLSPTDN
SNGVNWRTGSISLGRQQGPGMREPRLMSSCHRASRVSIYDNVPSSHLYASTGDLLDLEKD
GLLPQLDDILQHVNGIQEVVDDWSKNILPELQSHSTLAGDPGLSPFPSPNQVTLDFEGNS
VSEGRTTPSDVERDRTSLNESEATGVRERRDSGVGASLTRPNRRLRWSSFQLSHQPQPSP
ATPHISSQTAAQLNLLQRFSLLRLTAIMEKYSMSNKHGWTWSVPKFMKRIKAPDYRDKAV
FGVPLIVHVQRTGQPLPQSIQQALRYLRSNCLDQVGLFRKSGVKSRIHALRQMNENFPDN
VSYEDQSAYDVADMVKQFFRDLPEPLFTNKLSETFLHIYQYVPKEQRLQAVQAAILLLAD
ENREVLQTLLCFLHDVVNLVDENQMTPMNLAVCLAPSLFHLNLLKKESSPKVIQKKYATG
KPDQKDLNENLAAAQGLAHMITECNRLFEVPHEMVAQSRDSYLEAEIHVPSLEDLGAQLA
ESGATFHTYLEHLVQGLQKEAKEKFKGWVTCSSPDNTDLAFKKVGDGHPLKLWKASVEVE
APPSVVLNRVLRERHLWDEDFVQWKVVERLDKQTEIYQYVLNSMVPHPSRDFLVLRTWKT
DLPKGMCTLVSLSVEYEEAQLMGGVRAVVMDSQYLIEPCGSGKSRLTHICRIDLKGHSPE
WYSKGFGHLCAAEVTRIRNSFQPLVAEGPETKILI

  • Gold
  • Silver
  • Bronze
  • IntAct