Field Data
UniProt Accession: Q9Y4F1
Gene Name: FARP1
Gene Synonim: CDEP, PLEKHC2
GAP/GEF: GEF
Description: FERM, ARHGEF and pleckstrin domain-containing protein 1 (Chondrocyte-derived ezrin-like protein) (FERM, RhoGEF and pleckstrin domain-containing protein 1) (Pleckstrin homology domain-containing family C member 2) (PH domain-containing family C member 2)
Keywords: 3D-structure;Alternative splicing;Cell junction;Cell membrane;Cell projection;Complete proteome;Cytoplasm;Developmental protein;Guanine-nucleotide releasing factor;Membrane;Phosphoprotein;Polymorphism;Reference proteome;Repeat;Synapse;Synaptosome
Entrez ID: 10160
Ensembl Gene ID: ENSG00000152767
Ensembl Protein ID: ENSP00000365765
Our Specificity
Literature Specificity Cdc42, RhoA
Literature reference
Domain Composition:

Cellular Component

GO ID Description
GO:0005737cytoplasm
GO:0005856cytoskeleton
GO:0043197dendritic spine
GO:0005829cytosol
GO:0016020membrane
GO:0030425dendrite
GO:0030175filopodium
GO:0045202synapse
GO:0043005neuron projection
GO:0005886plasma membrane
GO:0042995cell projection
GO:0031234extrinsic component of cytoplasmic side of plasma membrane
GO:0030054cell junction

Molecular Function

GO ID Description
GO:0005089Rho guanyl-nucleotide exchange factor activity
GO:0030676Rac guanyl-nucleotide exchange factor activity
GO:0005085guanyl-nucleotide exchange factor activity
GO:0008092cytoskeletal protein binding

Biological Process

GO ID Description
GO:0043547positive regulation of GTPase activity
GO:0010923negative regulation of phosphatase activity
GO:0048813dendrite morphogenesis
GO:0035023regulation of Rho protein signal transduction
GO:0007275multicellular organism development
GO:0007416synapse assembly

Reactome

KEGG

Field Data
Localization in this study: plasma_membrane
Localization in the literature: cytosolic

Confocal Images

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Cytochalasin D Screen Negative

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organism orgs
Organism: Homo sapiens

Nucleotide Sequence

>FARP1
atgggagaaatagagcagaggccgaccccaggatcacgactgggggccccggaaaattcg
gggatcagtaccttggaacgtggacagaagccgcccccaacaccttcaggaaaactcgtg
tccatcaaaatccagatgctggatgacacccaggaggcatttgaagttccacaaagagct
cctgggaaggtgctgctggatgcagtttgcaaccacctcaacctcgtggaaggtgactat
tttggcctcgagtttcctgatcacaaaaagatcacggtgtggctggatctcctaaaaccc
attgtgaaacagattagaaggccaaagcacgttgttgttaagtttgtggtgaaattcttt
ccgcctgaccacacacaactccaagaagaactcacaaggtacctgttcgcgctgcaggtg
aagcaggacttggctcaaggcaggttgacgtgtaatgacaccagcgcagctctcttgatt
tcacacattgtgcaatctgagattggggattttgatgaagccttggacagagagcactta
gcaaaaaataaatacatacctcagcaagacgcactagaggacaaaatcgtggaatttcac
cataaccacattggacaaacaccagcagaatcagatttccagctcctagagattgcccgt
cggctagagatgtatggaatccggttgcacccggccaaggacagggaaggcacgaagatc
aatctggccgttgccaacacgggaattctagtgtttcagggtttcactaagatcaatgcc
ttcaactgggccaaggtgcggaagctgagcttcaagaggaagcgctttctcatcaagctc
cggccagatgccaatagtgcgtaccaggataccttggaattcctgatggccagtcgggat
ttctgcaagtccttctggaaaatctgtgttgaacatcatgccttctttagactttttgaa
gagcccaaaccaaagcccaagcccgtcctctttagccgggggtcatcatttcggttcagt
ggtcggactcagaagcaggttctcgactatgttaaagaaggaggacataagaaggtgcag
tttgaaaggaagcacagcaagattcattctatccggagccttgcttcacagcctacagaa
ctgaattcggaagtgctggagcagtctcagcagagcaccagccttacatttggagaaggt
gccgaatctccagggggccagagctgccggcgaggaaaggaaccgaaggtttccgccggg
gagccggggtcgcacccgagccctgcgccgaggagaagccccgcgggtaacaagcaggcg
gacggagccgcctcggcgcccacggaggaagaggaggaggtcgttaaggataggacccag
cagagtaaacctcagcccccgcagccaagcacaggctccctgactggcagtcctcacctt
tccgagctgtctgtgaactcgcaggggggagtggcccctgccaacgtgaccttgtctccc
aacctgagccccgacaccaagcaggcctctcccttgatcagcccgctgctgaatgaccag
gcctgcccccggacggacgatgaggatgagggccggaggaagagattcccaactgataaa
gcgtacttcatagctaaggaagtgtctaccaccgagcgaacatatctgaaggatctcgaa
gttatcacttcgtggtttcagagcacagtgagcaaagaggacgccatgccggaagcactg
aaaagtctcatattcccgaattttgaacctttgcacaaatttcatactaattttctcaag
gaaattgagcaacgacttgccctgtgggaaggccgctcaaatgcccaaatcagagattac
caaagaatcggcgatgtcatgctgaagaacattcagggcatgaagcacctggcggctcac
ctgtggaagcacagcgaggccttggaggccctggagaatggaatcaagagctcccggcgg
ctggagaacttctgcagagactttgagctgcagaaggtgtgttacctaccgctcaacacc
ttcctcctgcggccactgcaccggctcatgcactacaagcaggtcctggagcggctgtgc
aaacaccacccgccgagccacgccgacttcagggactgccgagccgctttggcagagatc
acggagatggtggcacagctccacggtacgatgatcaagatggagaatttccagaagctg
cacgaactcaagaaagatttgattggcattgacaatcttgtggttccgggaagggagttc
atccgtctgggcagcctcagcaagctctcggggaaggggctccagcagcgcatgttcttc
ctgttcaacgacgtcctgctatacacgagccgggggctgacggcctccaatcagtttaaa
gtccacgggcagctcccgctctatggcatgacgattgaggagagcgaagacgagtggggg
gtgccccactgcctgaccctccggggccagcggcagtccatcatcgtggccgccagttct
cggtccgagatggagaagtgggttgaggacatccagatggccattgacctggcggagaag
agcagcagccccgcccctgagttcctggccagcagcccccctgacaacaagtcccctgat
gaagccaccgcggctgaccaggagtcagaggatgacctgagcgcctcgcgcacatcgctg
gagcgccaggccccgcaccgcggcaacacaatggtgcacgtgtgctggcaccgcaacacc
agcgtctccatggtggacttcagcatcgcagtggagaatcagttgtctggaaacctgctg
aggaaattcaaaaacagcaacgggtggcagaagctgtgggtggtgttcacaaacttctgc
ctgttcttctacaaatcacaccaggacaatcatccccttgccagcctgcctctgctcggc
tactcgctcaccatcccctctgagtccgagaacatccagaaagactacgtgttcaagctg
cacttcaagtcccacgtctactacttcagggcggaaagcgagtacacgttcgaaaggtgg
atggaagtgatccgcagtgccaccagctctgcctcgcgaccccacgtgttgagtcacaaa
gagtctcttgtgtatt

Protein Sequence

>FARP1
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLVSIKIQMLDDTQEAFEVPQRA
PGKVLLDAVCNHLNLVEGDYFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVKFF
PPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAALLISHIVQSEIGDFDEALDREHL
AKNKYIPQQDALEDKIVEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDREGTKI
NLAVANTGILVFQGFTKINAFNWAKVRKLSFKRKRFLIKLRPDANSAYQDTLEFLMASRD
FCKSFWKICVEHHAFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVKEGGHKKVQ
FERKHSKIHSIRSLASQPTELNSEVLEQSQQSTSLTFGEGAESPGGQSCRRGKEPKVSAG
EPGSHPSPAPRRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQPSTGSLTGSPHL
SELSVNSQGGVAPANVTLSPNLSPDTKQASPLISPLLNDQACPRTDDEDEGRRKRFPTDK
AYFIAKEVSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFPNFEPLHKFHTNFLK
EIEQRLALWEGRSNAQIRDYQRIGDVMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRR
LENFCRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEI
TEMVAQLHGTMIKMENFQKLHELKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFF
LFNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASS
RSEMEKWVEDIQMAIDLAEKSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRTSL
ERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSGNLLRKFKNSNGWQKLWVVFTNFC
LFFYKSHQDNHPLASLPLLGYSLTIPSESENIQKDYVFKLHFKSHVYYFRAESEYTFERW
MEVIRSATSSASRPHVLSHKESLVY

  • Gold
  • Silver
  • Bronze
  • IntAct